AIR POLLUTION AND THE INLAND PORT

Thousands of studies have established that air pollution is a broad-based health hazard, provoking a long list of diseases very similar in type and scope to those related to smoking cigarettes, including shortened life expectancy, and premature death. Furthermore, there is no
safe level of pollution. The more pollution, the greater the adverse health outcomes. The relationship between air pollution and poor health is hyperbolic as demonstrated by the graph below.1 It shows that there is no safe level of pollution, and that per unit of exposure, and the relationship between poor health and air pollution is even stronger at low doses.

From any baseline, any increase in air pollution will have public health consequences. While what has been revealed about the inland port is still vague, it has become increasingly clear that there is no scenario under which a port would not be a significant new source of air pollution for the Salt Lake Valley and other areas of the Wasatch Front. A robust, “successful”
port would increase pollution from three types of mobile sources carrying various commodities–diesel powered trucks, train locomotives, and air cargo.

The common denominator for most of the health consequences of air pollution is the provocation of an inflammatory response that affects the vascular system and, downstream, all major organs including the placenta of a pregnant mother. Premature death is precipitated through multiple mechanisms–heart disease (heart attacks, abnormal heart rhythms, aggravation of heart failure), strokes, lung disease (pneumonia, asthma, respiratory failure), and cancer. Air pollution damages chromosomal function and impairs fetal development, causing birth defects,
miscarriages, still births and higher rates of infant deaths. Furthermore, air pollution triggers just about every other type of pregnancy/fetal development complication that can translate into life long impacts on adult health–low birth weight, premature birth, pre-eclampsia, premature
rupture of membranes, placenta previa and accreta, and uterine inflammation.

The World Health Organization has declared air pollution the most important environmental cause of cancer, especially for increasing the risk of lung and bladder cancer. However, just about every other type of cancer has been shown to occur at increased rates among populations exposed to more air pollution. Other studies show that cancer survival is also decreased among patients exposed to more air pollution.

Perhaps the greatest impact of air pollution on public health is the damage it can do to chromosomal function which can be passed on to future generations. At least three generations can be harmed by air pollution exposure. Even modest levels of air pollution can impair the chromosomes of germ cells of future parents, negatively affecting the health of children even prior to conception.

While port related pollution will extend throughout the Wasatch Front, there is also little doubt that the NW Quadrant itself will become a new pollution hotspot, nearby neighborhoods will bear the brunt of the health consequences from the port and could be characterized as “sacrifice zones.”

Other inland ports in other cities have been burdened by the pollution from hundreds to thousands of new semi trucks, and dozens of additional fully loaded trains. A recent study of the Los Angeles airport has also shown that emissions from aviation traffic are much larger than previously estimated, doubling particulate pollution downwind as far out as ten miles, and increasing levels four to five times above baseline, as far out as 5-6 miles. The study estimated that the city’s airport was responsible for as much pollution as the city’s freeway network.2 This lends evidence to the expectation that air cargo related to an inland port will also be a
significant new source of pollution.

Diesel emissions will be a major part of the increased pollution. A recent landmark study indicates that long term exposure to even low levels of diesel exhaust raises the risk of dying from lung cancer about 50% for residents who live near industrial operations, and about 300% for the workers.3,4

In response to these studies, Joseph Fraumeni Jr., Director of the National Cancer Institute’s Division of Cancer Epidemiology and Genetics, stated, “The findings suggest that the risks may extend to other workers exposed to diesel exhaust and to people living in urban areas where diesel exhaust levels are elevated.”

Increased large truck traffic will add to existing congestion on Salt Lake Valley freeways, which will add further emissions of pollutants and greenhouse gases from non-port vehicles on the freeway network.5

Details of all the medical consequences of air pollution and their scientific basis are far beyond the scope of this summary. Attached as an appendix is a summary of the information from nearly 1,300 studies.

Peters, A. Air Quality and Cardiovascular Health: Smoke and Pollution Matter. Circulation.
2009: 120:924-927
Hudda N, et al. Emissions from an International Airport Increase Particle Number
Concentrations 4-fold at 10 km Downwind. Environ. Sci. Technol., 2014, 48 (12), pp 6628–
DOI: 10.1021/es5001566
Silverman DT, Samanic CM, Lubin JH, et al. The diesel exhaust in miners study: a nested
case- control study of lung cancer and diesel exhaust. J Natl Cancer Inst. March 2, 2012. doi:
10.1093/jnci/ djs034.
Attfield MD, Schlieff PL, Lubin JH, et al. The diesel exhaust in miners study: a cohort
mortality study with emphasis on lung cancer. J Natl Cancer Inst. March 2, 2012. doi:10.1093/
jnci/djs035.
Zhang K, Batterman S, Dion F. Vehicle emissions in congestion: Comparison of work zone,
rush hour and free-flow conditions. Atmospheric Environment 45 (2011) 1929e1939

APPENDIX

THE HEALTH CONSEQUENCES OF AIR POLLUTION
PREPARED BY UTAH PHYSICIANS FOR A HEALTHY ENVIRONMENT
UPDATED APRIL, 2019

Pollution and the Cardiovascular System

The signature physiologic consequence of air pollution is the same as cigarette smoke: a low grade arterial inflammation, arteriolar narrowing, and vascular prothrombotic changes. Chemical markers of these changes are found even in young healthy adults. As with cigarette smoke the effect can be almost immediate and chronic exposure to even low concentrations of pollution are associated with an acceleration of atherosclerosis and significant arteriolar narrowing and stiffness. Breathing more ozone in childhood increases arterial wall thickness in young adults.
Simultaneously high concentrations of multiple pollutants have a synergistic effect on hospitalizations for cardiac disease.
Air pollution causes average blood pressure to increase within minutes. All organs are affected. Blood pressure rises are found in even in children.
Air pollution can alter electrical signaling within the heart. Rates of arrhythmias, heart attacks and strokes increase with air pollution and are the primary cause for increased community mortality rates. Those rates increase within hours after exposure and stay elevated for as long as 30 days after the exposure has ended.
In patients who suffer from heart failure, air pollution reduces cardiac function. Even in patients without known heart disease, air pollution increases the size of heart chambers, indicative of impaired function, a precursor of heart failure.
Particulate pollution concentrations typical of the Wasatch Front increase mortality rates about 10% according to the formula recommended by the American Heart Association published in May, 2010. A subsequent study suggests that number should be 14%. That means between 1,000 and 2,000 Utahns die prematurely every year due to our air pollution. Approximately 210,000 premature deaths occur annually in the US from combustion emissions. The average pollution related premature death represents about ten years of lost life.
Particulate pollution from coal and diesel combustion are likely much more potent in triggering heart and vascular disease than most other sources.
Mortality plotted against air pollution concentrations shows no safe threshold, even at low levels, well below EPA national ambient air quality standards (NAAQS). Furthermore this curve is not linear. The steepest part of the curve is at low doses, i.e. small air pollution reductions have even greater public health benefit when the concentrations are already low. Even at what are considered ‘background’ levels of particulate pollution there are increased risks for cardiopulmonary mortality compared to clean, filtered air.
Air pollution impairs exercise capability, even in the very fittest of individuals. Even in young, healthy adults air pollution increases biomarkers of inflammation and thrombosis and increases blood pressure and heart rate. Air pollution offsets the cardiorespiratory benefits of exercise.
Air pollution shortens life expectancy and accelerates the aging process. The residents of the average American city lose 1-3 years of life expectancy, in Northern China residents lose 5.5 years.
The increase in mortality risk persists for decades after exposure.
There are very likely genetic differences in human susceptibility to the arterial inflammation provoked by air pollution. Furthermore, the progression of inflammation and cardiovascular changes are more pronounced in those who are already at higher risk.
Inhaled nanoparticles preferentially lodge in the lining of blood vessels where inflammation and atherosclerosis already exist, and they can remain there for months, and perhaps much longer.
Air pollution alters the blood lipid profile, decreasing HDL levels.
Black Americans suffer greater cardiovascular impacts from air pollution than caucasians.
Radioactive isotopes attached to particulate pollution carry additional cardiovascular risks.

Brook R, Rajagopalan S, Pope CA, Brook J, Bhatnagar A, et al. AHA Scientific Statement:
Particulate Matter Air Pollution and Cardiovascular Disease; An Update to the Scientific
Statement From the American Heart Association. Circulation. 2010;121:2331-2378.
Peters, A, and Pope, CA III Editorial, Lancet. Vol 360, Oct 19, 2002
Pope CA III, Muhlestein JB, May HT et al. Ischemic Heart Disease Events Triggered by
Short-term Exposure to Fine Particulate Air Pollution. Circulation 2006, 114:2443-2448.
Dockery DW, Stone PH. Cardiovascular Risks from Fine Particulate Air Pollution. NEJM
2007; 356:511-513
Miller KA, Siscovick DS, Sheppard L et al. Long-term Exposure to Air Pollution and
Incidence of Cardiovascular Events in Women. NEJM 2007; 356:447-458.
Peters, A. Air Quality and Cardiovascular Health: Smoke and Pollution Matter. Circulation.
2009: 120:924-927
Peters A, von Klot S, Heier M, et al. Exposure to Traffic and the Onset of Myocardial
Infarction. NEJM Vol. 351:1721-1730.
Shang-Shyue Tsai, William B. Goggins, Hui-Fen Chiu, and Chun-Yuh Yang. Evidence for an
Association Between Air Pollution and Daily Stroke Admissions in Kaohsiung, Taiwan. Stroke
2003;34:2612-2616
Eugenia E. Calle and Michael J. Thun C. Arden Pope, III, Richard T. Burnett, Daniel
Krewski, Michael Jerrett, Yuanli Shi. Circulation. 2009;120:941-948. Cardiovascular Mortality
and Exposure to Airbourne Fine Particulate Matter and Cigarette Smoke.
Hoffman B. Presentation, American Thoracic Society (2010, May 17) Higher blood pressure found in people living in urban areas.
Kunzil N, Jerrett M, Garcia-Esteban, R, et al. Ambient Air Pollution and the Progression of
Atherosclerosis in Adults. PloS ONE, 2010; 2010; 5 (2): e9096 DOI: 10.1371/journal.pone.
0009096
Pope, CA III, Ezzate, M., Dockery, D. Fine-Particulate Air Pollution and Life Expectancy in
the United States. NEJM. Vol. 360:376-386 Jan. 22, 2009 Num. 4.
Baccarelli A, Martinelli A, Zanobetti A, et al. Exposure to particulate air pollution and risk
of deep vein thrombosis. Arch Intern Med. 2008; 168:920-927
Jacobs L, Emmerechts J, Mathieu C, Hoylaerts MF, Fierens F, Hoet PH, Nemery B, Nawrot
TS. Air pollution related prothrombotic changes in persons with diabetes. Environ Health
Perspect. 2010 Feb;118(2):191-6.
Adar SD, Klein R, Klein BE, Szpiro AA, Cotch MF, Wong TY, O’Neill MS, Shrager S, Barr
RG, Siscovick DS, Daviglus ML, Sampson PD, Kaufman JD. Air Pollution and the
Microvasculature: A Cross-Sectional Assessment of In Vivo Retinal Images in the Population-
Based Multi-Ethnic Study of Atherosclerosis (MESA). PLoS Med. 2010 Nov 30;7(11):e1000372
Koehoorn M, Davies Gan WQHW, Demers PA, Tamburic L, Brauer M. Long-Term
Exposure to Traffic-Related Air Pollution and the Risk of Coronary Heart Disease
Hospitalization and Mortality. Environ Health Perspect. 2010 Nov 16. [Epub ahead of print]
Bauer M, Moebus S, Möhlenkamp S, Dragano N, Nonnemacher M, Fuchsluger M, Kessler
C, Jakobs H, Memmesheimer M, Erbel R, Jöckel KH, Hoffmann B; HNR Study Investigative
Group. Urban Particulate Matter Air Pollution Is Associated With Subclinical Atherosclerosis
Results From the HNR (Heinz Nixdorf Recall) Study. J Am Coll Cardiol. 2010 Nov 23;56(22):
1803-1808.
Silverman RA, Ito K, Freese J, Kaufman BJ, De Claro D, Braun J, Prezant DJ. Association
of Ambient Fine Particles With Out-of-Hospital Cardiac Arrests in New York City. Am J
Epidemiol. 2010 Aug 20. [Epub ahead of print]
American College of Cardiology (2008, August 14). Air Pollution Damages More Than
Lungs: Heart And Blood Vessels Suffer Too.
Kallio K, et al. Arterial Intima-Media Thickness, Endothelial Function, and Apolipoproteins
in Adolescents Frequently Exposed to Tobacco Smoke. Circulation: Cardiovascular Quality and
Outcomes. 2010. Published online before print March 2, 2010, doi: 10.1161/CIRCOUTCOMES.
109.857771
Federation of American Societies for Experimental Biology (2010, April 28). Mexico City
air pollution adversely affects the hearts of young people. ScienceDaily. Retrieved April 29,
2010, from http://www.sciencedaily.com /releases/2010/04/100428153256.htm
American Heart Association (2010, July 22). Smog might trigger cell death in the heart, study finds. ScienceDaily. Retrieved June 25,
Delfino RJ, Tjoa T, Gillen DL, Staimer N, Polidori A, Arhami M, Jamner L, Sioutas C,
Longhurst J. Traffic-related air pollution and blood pressure in elderly subjects with coronary
artery disease. Epidemiology. 2010 May;21(3):396-404.
Urch B, Silverman F, Corey P, Brook J, Lukic K, Rajagopalan S, Brook R. Acute Blood
Pressure Responses in Healthy Adults During Controlled Air Pollution Exposures. Environ
Health Perspect. 2005 August; 113(8): 1052–1055.
Ruckerl, R. et al. (2007) Air pollution and inflammation (interleukin-6, C-reactive protein,
fibrinogen) in myocardial infarction survivors. Environ. Health Perspect. 115, 1072–1080.
Pham, H, AC Bonham, KE Pinkerton and CY Chen. 2009. Central neuroplasticity and
decreased heart rate variability following particulate matter exposure in mice. Environmental
Health Perspectives doi: 10.1289/ehp.0900674.
Alexeeff SE, Coull BA, Gryparis A, Suh H, Sparrow D, Vokonas PS, Schwartz J. Medium-
Term Exposure to Traffic-Related Air Pollution and Markers of Inflammation and Endothelial
Function. Environ Health Perspect. 2011 Feb 24. [Epub ahead of print]
Nawrot TS, et al. Heart attacks: Public health importance of triggers of myocardial
infaction: a comparative risk assessment. The Lancet, Vol. 377, February 26, 2011, p. 732.
DOI: 10.1016/S0140-6736(10)62296-9
Davoodi G, Sharif AY, Kazemisaeid A, Sadeghian S, Farahani AV, Sheikhvatan M, Pashang
M. Comparison of heart rate variability and cardiac arrhythmias in polluted and clean air
episodes in healthy individuals. Environ Health Prev Med. 2010 Jul;15(4): 217-21. Epub 2010
Jan 22.
Bai N, Kido T, Suzuki H, Yang G, Kavanagh TJ, Kaufman JD, Rosenfeld ME, van Breemen
C, Eeden SF. Changes in atherosclerotic plaques induced by inhalation of diesel exhaust.
Atherosclerosis. 2011 Mar 2. [Epub ahead of print]
Kampfrath T, Maiseyeu A, Ying Z, Shah Z, Deiuliis JA, et al. Chronic Fine Particulate
Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4
Pathways. Circulation Research, 2011; 108 (6): 716 DOI: 10.1161/ CIRCRESAHA.110.237560
Harrison CM, Pompilius M, Pinkerton KE, Ballinger SW 2011. Mitochondrial Oxidative
Stress Significantly Influences Atherogenic Risk and Cytokine-Induced Oxidant Production.
Environ Health Perspect 119:676-681. doi:10.1289/ehp.1002857
Brook RD, Shin HH, Bard RL, Burnett RT, Vette A, Croghan C, et al. 2011. Exploration of
the Rapid Effects of Personal Fine Particulate Matter Exposure on Arterial Hemodynamics and
Vascular Function during the Same Day. Environ Health Perspect 119:688-694. doi:10.1289/
ehp.1002107
Sérgio Chiarelli P, Amador Pereira LA, Nascimento Saldiva PH, Ferreira Filho C, Bueno
9
Garcia ML, Ferreira Braga AL, Conceição Martins L. The association between air pollution
and blood pressure in traffic controllers in Santo André, São Paulo, Brazil. Environ Res. 2011
May 11. [Epub ahead of print]
Chiusolo M, Cadum E, Stafoggia M, Galassi C, Berti G, Faustini A, Bisanti L, Vigotti MA,
Dessì MP, Cernigliaro A, Mallone S, Pacelli B, Minerba S, Simonato L, Forastiere F. Short
Term Effects of Nitrogen Dioxide on Mortality and Susceptibility Factors in Ten Italian Cities:
the EpiAir Study. Environ Health Perspect. 2011 May 17. [Epub ahead of print]
Domínguez-Rodríguez A, Abreu-Afonso J, Rodríguez S, Juárez-Prera RA, Arroyo- Ucar E,
Jiménez-Sosa A, González Y, Abreu-González P, Avanzas P. Comparative Study of Ambient Air
Particles in Patients Hospitalized for Heart Failure and Acute Coronary Syndrome. Rev Esp
Cardiol. 2011 Aug;64(8):661-6. Epub 2011 Jun 8.
Pope CA, et al. Short-Term Exposure to Fine Particulate Matter Air Pollution Is
Preferentially Associated With the Risk of ST-Segment Elevation Acute Coronary Events. J Am
Heart Assoc. 2015 Dec 8;4(12). pii: e002506. doi: 10.1161/JAHA.115.002506.
Mallone S, Stafoggia M, Faustini A, Gobbi GP, Marconi A, Forastiere F 2011. Saharan
Dust and Associations between Particulate Matter and Daily Mortality in Rome, Italy. Environ
Health Perspect. doi:10.1289/ehp.1003026
Nuvolone D, Balzi D, Chini M, Scala D , Giovannini F, and Barchielli A . Short- Term
Association Between Ambient Air Pollution and Risk of Hospitalization for Acute Myocardial
Infarction: Results of the Cardiovascular Risk and Air Pollution in Tuscany (RISCAT) Study.
American Journal of Epidemiology Volume174, Issue1Pp. 63-71.
Williams R, Brook R, Bard R, Conner T, Shin H, Burnett R. Impact of personal and ambientlevel
exposures to nitrogen dioxide and particulate matter on cardiovascular function. Int J
Environ Health Res. 2011 Jun 28. [Epub ahead of print]
Mills NL, Miller MR, Lucking AJ, Beveridge J, Flint L, Boere AJ, Fokkens PH, Boon NA,
Sandstrom T, Blomberg A, Duffin R, Donaldson K, Hadoke PW, Cassee FR, Newby DE.
Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust
inhalation. European Heart Journal, July 13, 2011 DOI:10.1093/eurheartj/ ehr195
Fattore E, Paiano V, Borgini A, Tittarelli A, Bertoldi M, Crosignani P, Fanelli R. Human
health risk in relation to air quality in two municipalities in an industrialized area of Northern
Italy. Environ Res. 2011 Jul 15. [Epub ahead of print]
Meyer G, Boissiere J, Tanguy S, Rugale C, Gayrard S, Jover B, Obert P, Reboul C. Carbon
Monoxide Pollution Impairs Myocardial Perfusion Reserve: Implication of Coronary
Endothelial Dysfunction. Cardiovasc Toxicol. 2011 Jul 27. [Epub ahead of print].
Ayotte, P, A Carrier, N Ouellet, V Boiteau, B Abdous, EAL Sidi, ML Château-Degat and E
10
Dewailly. 2011. Relation between methylmercury exposure and plasma paraoxonase activity in
Inuit adults from Nunavik. Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.
1003296.
Chen R, Pan G, Zhang Y, Xu Q, Zeng G, Xu X, Chen B, Kan H. Ambient carbon monoxide
and daily mortality in three Chinese cities: The China Air Pollution and Health Effects Study
(CAPES). Sci Total Environ. 2011 Sep 10. [Epub ahead of print]
Van Hee VC, Szpiro AA, Prineas R, Neyer J, Watson K, Siscovick D, Park SK, Kaufman JD.
Association of Long-term Air Pollution With Ventricular Conduction and Repolarization
Abnormalities. Epidemiology. 2011 Sep 13. [Epub ahead of print]
Breitner S, Liu L, Cyrys J, Brüske I, Franck U, Schlink U, Leitte AM, Herbarth O,
Wiedensohler A, Wehner B, Hu M, Pan XC, Wichmann HE, Peters A. Sub-micrometer
particulate air pollution and cardiovascular mortality in Beijing, China. Sci Total Environ.
2011 Sep 20. [Epub ahead of print]
Bhaskaran K, Hajat S, Armstrong B, Haines A, Herrett E, Wilkinson P, Smeeth L. The
effects of hourly differences in air pollution on the risk of myocardial infarction: case crossover
analysis of the MINAP database. BMJ. 2011 Sep 20;343:d5531. doi: 10.1136/bmj.d5531.
Weichenthal S, Kulka R, Dubeau A, Martin C, Wang D, Dales R 2011. Traffic- Related Air
Pollution and Acute Changes in Heart Rate Variability and Respiratory Function in Urban
Cyclists. Environ Health Perspect 119:1373-1378. http://dx.doi.org/ 10.1289/ehp.1003321
Szyszkowicz M, Rowe BH, Brook RD. Even Low Levels of Ambient Air Pollutants Are
Associated With Increased Emergency Department Visits for Hypertension. Can J Cardiol. 2011
Sep 23. [Epub ahead of print]
Perepu RS, Dostal DE, Garcia C, Kennedy RH, Sethi R. Cardiac dysfunction subsequent to
chronic ozone exposure in rats. Mol Cell Biochem. 2011 Sep 27. [Epub ahead of print]
Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, et al. 2011.
Opposing Effects of Particle Pollution, Ozone and Ambient Temperature on Arterial Blood
Pressure. Environ Health Perspect :-. http://dx.doi.org/10.1289/ehp. 1103647
Cakmak S, Dales R, Leech J, Liu L. The influence of air pollution on cardiovascular and
pulmonary function and exercise capacity: Canadian Health Measures Survey (CHMS). Environ
Res. 2011 Oct 13. [Epub ahead of print]
Emmerechts J, Hoylaerts MF. The effect of air pollution on haemostasis. Hamostaseologie.
2011 Oct 18;32(1). [Epub ahead of print]
Elliott CT, Copes R. Burden of mortality due to ambient fine particulate air pollution
(PM2.5) in interior and Northern BC. Can J Public Health. 2011 Sep-Oct;102(5):390-3.
Hoffmann B, et al. Opposing effects of particle pollution, ozone and ambient temperature on
arterial blood pressure. Environmental Health Perspectives. Published online October 21,
11
doi:10.1289/ehp.1103647.
Andersen ZJ, Kristiansen LC, Andersen KK, Olsen TS, Hvidberg M, Jensen SS, Ketzel M,
Loft S, Sørensen M, Tjønneland A, Overvad K, Raaschou-Nielsen O. Stroke and Long-Term
Exposure to Outdoor Air Pollution From Nitrogen Dioxide. Published online before print
November 3, 2011, doi: 10.1161/ STROKEAHA.111.629246
Emmerechts J, Jacobs L, Van Kerckhoven S, Loyen S, Mathieu C, Fierens F, Nemery B,
Nawrot TS, Hoylaerts MF. Air Pollution-Associated Procoagulant Changes: role of Circulating
Microvesicles. J Thromb Haemost. 2011 Nov 8. doi: 10.1111/j. 1538-7836.2011.04557.x. [Epub
ahead of print]
Hampel R, Breitner S, Schneider A, Zareba W, Kraus U, Cyrys J, Geruschkat U, Belcredi P,
Müller M, Wichmann HE, Peters A. Acute air pollution effects on heart rate variability are
modified by SNPs involved in cardiac rhythm in individuals with diabetes or impaired glucose
tolerance. Environ Res. 2011 Nov 7. [Epub ahead of print]
Fuks K, Moebus S, Hertel S, Viehmann A, Nonnemacher M, Dragano N, et al. 2011. Long-
Term Urban Particulate Air Pollution, Traffic Noise, and Arterial Blood Pressure. Environ
Health Perspect 119:1706-1711. http://dx.doi.org/10.1289/ehp.1103564
Baccarelli A, Barretta F, Dou C, Zhang X, McCracken JP, Diaz A, Bertazzi PA, Schwartz J,
Wang S, Hou L. Effects of Particulate Air Pollution on Blood Pressure in a Highly Exposed
Population in Beijing, China: A repeated-measure study. Environ Health. 2011 Dec 21;10(1):
[Epub ahead of print]
Langrish JP, Li X, Wang S, Lee MM, Barnes GD, Miller MR, et al. 2012. Reducing Personal
Exposure To Particulate Air Pollution Improves Cardiovascular Health In Patients With
Coronary Heart Disease. Environ Health Perspect :-. http://dx.doi.org/ 10.1289/ehp.1103898
Chen SY, Su TC, Lin YL, Chan CC. Short-term Effects of Air Pollution on Pulse Pressure
Among Nonsmoking Adults. Epidemiology. 2012 Jan 16. [Epub ahead of print]
Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, et al. 2011.
Opposing Effects of Particle Pollution, Ozone, and Ambient Temperature on Arterial Blood
Pressure. Environ Health Perspect 120:241-246. http://dx.doi.org/ 10.1289/ehp.1103647
Wellenius G, Burger M, Coull B, Schwartz J, et al. Ambient Air Pollution and the Risk of
Acute Ischemic Stroke. Arch Intern Med. 2012;172(3):229-234. doi:10.1001/ archinternmed.
2011.732
Mustafić H, Jabre P, Caussin C, Murad M, et al. Main Air Pollutants and Myocardial
Infarction: A Systematic Review and Meta-analysis. JAMA 2012. vol 307, no. 7 pg 713-721.
Nurkiewicz TR, Porter DW, Hubbs AF, Stone S, Moseley AM, Cumpston JL, Goodwill AG,
Frisbee SJ, Perrotta PL, Brock RW, Frisbee JC, Boegehold MA, Frazer DG, Chen BT,
Castranova V. Pulmonary particulate matter and systemic microvascular dysfunction. Res Rep
12
Health Eff Inst. 2011 Dec;(164):3-48.
Channell MM, Paffett ML, Devlin RB, Madden MC, Campen MJ. Circulating factors induce
coronary endothelial cell activation following exposure to inhaled diesel exhaust and nitrogen
dioxide in humans: Evidence from a novel translational in vitro model. Toxicol Sci. 2012 Feb
[Epub ahead of print]
Schwartz J, Alexeeff SE, Mordukhovich I, Gryparis A, Vokonas P, Suh H, Coull BA.
Association between long-term exposure to traffic particles and blood pressure in the Veterans
Administration Normative Aging Study. Occup Environ Med. 2012 Mar 1. [Epub ahead of print]
Cosselman KE, Krishnan RM, Oron AP, Jansen K, Peretz A, Sullivan JH, Larson TV,
Kaufman JD. Blood Pressure Response to Controlled Diesel Exhaust Exposure in Human
Subjects. Hypertension. 2012 Mar 19. [Epub ahead of print]
Feng J, Yang W. Effects of particulate air pollution on cardiovascular health: a population
health risk assessment. PLoS One. 2012;7(3):e33385. Epub 2012 Mar 14.
Tonne C, Yanosky JD, Beevers S, Wilkinson P, Kelly FJ. PM Mass Concentration and PM
Oxidative Potential in Relation to Carotid Intima-media Thickness. Epidemiology. 2012 Mar 23.
[Epub ahead of print]
Lepeule J, Laden F, Dockery D, Schwartz J. Chronic Exposure to Fine Particles and
Mortality: An Extended Follow-Up of the Harvard Six Cities Study from 1974 to 2009. Environ
Health Perspect. 2012 Mar 28. [Epub ahead of print]
Martinelli N, Girelli D, Cigolini D, Sandri M, Ricci G, Rocca G, Olivieri O. Access rate to
the emergency department for venous thromboembolism in relationship with coarse and fine
particulate matter air pollution. PLoS One. 2012;7(4):e34831. Epub 2012 Apr 11.
Chen R, Kan H, Chen B, Huang W, Bai Z, Song G, Pan G. Association of Particulate Air
Pollution With Daily Mortality: The China Air Pollution and Health Effects Study. Am J
Epidemiol. 2012 Apr 17. [Epub ahead of print]
J. Lambrechtsen, O. Gerke, K. Egstrup, N. P. Sand, B. L. Nørgaard, H. Petersen, H.
Mickley, A. C. P. Diederichsen. The relation between coronary artery calcification in
asymptomatic subjects and both traditional risk factors and living in the city centre: a DanRisk
substudy. Journal of Internal Medicine, 2012; 271 (5): 444 DOI: 10.1111/j.
1365-2796.2011.02486.x
Beckerman BS, Jerrett M, Finkelstein M, Kanaroglou P, Brook JR, Arain MA, Sears MR,
Stieb D, Balmes J, Chapman K. The association between chronic exposure to traffic-related air
pollution and ischemic heart disease. J Toxicol Environ Health A. 2012 Apr 1;75(7):402-11.
Jia X, Hao Y, Guo X. Ultrafine carbon black disturbs heart rate variability in mice. Toxicol
Lett. 2012 Apr 15. [Epub ahead of print]
Van Eeden S, Leipsic J, Man SF, Sin DD. The Relationship Between Lung Inflammation and
13
Cardiovascular Disease. Am J Respir Crit Care Med. 2012 Apr 26. [Epub ahead of print]
Crouse DL, Peters PA, van Donkelaar A, Goldberg MS, Villeneuve PJ, Brion O, et al. 2012.
Risk of Nonaccidental and Cardiovascular Mortality in Relation to Long-term Exposure to Low
Concentrations of Fine Particulate Matter: A Canadian National-Level Cohort Study. Environ
Health Perspect 120:708-714. http://dx.doi.org/10.1289/ehp. 1104049
Kloog I, Coull BA, Zanobetti A, Koutrakis P, Schwartz JD (2012) Acute and Chronic Effects
of Particles on Hospital Admissions in New-England. PLoS ONE 7(4): e34664. doi:10.1371/
journal.pone.0034664
Golomb E, Matza D, Cummings CA, Schwalb H, Kodavanti UP, Schneider A, Houminer E,
Korach A, Nyska A, Shapira OM. Myocardial Mitochondrial Injury Induced by Pulmonary
Exposure to Particulate Matter in Rats. Toxicol Pathol. 2012 May 1. [Epub ahead of print]
Rosenbloom J, Wilker E, Mukamal K, Schwartz J, Mittleman M. Residential Proximity to
Major Roadway and 10-Year All-Cause Mortality After Myocardial Infarction Circulation.
2012;125:2197-2203, published online before print May 7 2012, doi: 10.1161/
CIRCULATIONAHA.111.085811
Rich D, Kipen H, Huang W, Wang G, Wang Y, Zhu P, et al. Association Between Changes in
Air Pollution Levels During the Beijing Olympics and Biomarkers of Inflammation and
Thrombosis in Healthy Young Adults JAMA. 2012;307(19): 2068-2078. doi:10.1001/jama.
2012.3488
Pieters N, Plusquin M, Cox B, Kicinski M, Vangronsveld J, Nawrot TS. An epidemiological
appraisal of the association between heart rate variability and particulate air pollution: a metaanalysis.
Heart. 2012 May 23. [Epub ahead of print]
Rich DQ, Kipen HM, Huang W, Wang G, Wang Y, Zhu P, Ohman-Strickland P, Hu M,
Philipp C, Diehl SR, Lu SE, Tong J, Gong J, Thomas D, Zhu T, Zhang JJ. Association between
changes in air pollution levels during the Beijing Olympics and biomarkers of inflammation and
thrombosis in healthy young adults. JAMA. 2012 May 16;307(19):2068-78.
Jacobs L, Buczynska A, Walgraeve C, Delcloo A, Potgieter-Vermaak S, Van Grieken R,
Demeestere K, Dewulf J, Van Langenhove H, De Backer H, Nemery B, Nawrot TS. Acute
changes in pulse pressure in relation to constituents of particulate air pollution in elderly
persons. Environ Res. 2012 Jun 18. [Epub ahead of print]
Devlin R, Duncan K, Jardim M, Schmitt M, Rappold A, Diaz-Sanchez D. Controlled
Exposure of Healthy Young Volunteers to Ozone Causes Cardiovascular Effects. Circulation
2012; June 25 2012, doi:10.1161/CIRCULATIONAHA.112.094359
Cesaroni G, Porta D, Badaloni C, Stafoggia M, Eeftens M, Meliefste K, Forastiere F.
Nitrogen dioxide levels estimated from land use regression models several years apart and
association with mortality in a large cohort study. Environ Health. 2012 Jul 18;11(1):48.
14
[Epub ahead of print]
Berman JD, Fann N, Hollingsworth JW, Pinkerton KE, Rom WN, Szema AM, et al. 2012.
Health Benefits from Large Scale Ozone Reduction in the United States. Environ Health
Perspect :-. http://dx.doi.org/10.1289/ehp.1104851
Chen R, Huang W, Wong CM, Wang Z, Quoc Thach T, Chen B, Kan H Short-term exposure
to sulfur dioxide and daily mortality in 17 Chinese cities: The China air pollution and health
effects study (CAPES). Environ Res. 2012 Jul 23. [Epub ahead of print]
Meng X, Zhang Y, Zhao Z, Duan X, Xu X, Kan H. Temperature modifies the acute effect of
particulate air pollution on mortality in eight Chinese cities. Sci Total Environ. 2012 Jul
30;435-436C:215-221. [Epub ahead of print]
Breton CV, Wang X, Mack WJ, Berhane K, Lopez M, Islam TS, Feng M, Lurmann F,
McConnell R, Hodis HN, Künzli N, Avol E. Childhood Air Pollutant Exposure and Carotid
Artery Intima-Media Thickness in Young Adults. Circulation. 2012 Aug 15. [Epub ahead of
print]
Perez L, Tobías A, Querol X, Pey J, Alastuey A, Díaz J, Sunyer J. Saharan dust, particulate
matter and cause-specific mortality: A case-crossover study in Barcelona (Spain). Environ Int.
2012 Aug 23;48C:150-155. [Epub ahead of print]
Wang T, Wang L, Moreno-Vinasco L, Lang GD, Siegler JH, Mathew B, Usatyuk PV, Samet
JM, Geyh AS, Breysse PN, Natarajan V, Garcia JG. Particulate matter air pollution disrupts
endothelial cell barrier via calpain-mediated tight junction protein degradation. Part Fibre
Toxicol. 2012 Aug 29;9(1):35. [Epub ahead of print]
Crabbe H. Risk of respiratory and cardiovascular hospitalisation with exposure to bushfire
particulates: new evidence from Darwin, Australia. Environ Geochem Health. 2012 Oct 5.
[Epub ahead of print]
Bedada GB, Smith CJ, Tyrrell PJ, Hirst AA, Agius R. Short-term effects of ambient
particulates and gaseous pollutants on the incidence of transient ischaemic attack and minor
stroke: a case- crossover study. Environ Health. 2012 Oct 15;11(1):77. [Epub ahead of print]
Wu S, Deng F, Huang J, Wang H, Shima M, Wang X, Qin Y, Zheng C, Wei H, Hao Y, Lv H,
Lu X, Guo X. Blood Pressure Changes and Chemical Constituents of Particulate Air Pollution:
Results From The Healthy Volunteer Natural Relocation (HVNR) Study. Environ Health
Perspect (): .doi:10.1289/ehp.1104812
Wichmann J, Voyi K. Ambient air pollution exposure and respiratory, cardiovascular and
cerebrovascular mortality in cape town, South Africa: 2001–2006. Int J Environ Res
Public Health. 2012 Nov 5;9(11):3978-4016. doi: 10.3390/ijerph9113978.
Madrigano J, Kloog I, Goldberg R, Coull BA, Mittleman MA, Schwartz J. Long- term
Exposure to PM2.5 and Incidence of Acute Myocardial Infarction. Environ Health Perspect.
15
2012 Nov 29. [Epub ahead of print]
Correia A, Pope CA, Dockery D, Wang Y, Ezzati M, Dominici F. Effect of Air Pollution
Control on Life Expectancy in the United States: An Analysis of 545 U.S. Counties for the
Period from 2000 to 2007 Epidemiology. 3 December 2012 doi: 10.1097/EDE.
0b013e3182770237
Atkinson R, Carey I, Kent A, van Staa T, Anderson HR, Cook D Long-Term Exposure to
Outdoor Air Pollution and Incidence of Cardiovascular Diseases. Epidemiology, 5 December
doi: 10.1097/EDE 0b013e318276ccb8
Cesaroni G, Badaloni C, Gariazzo C, Stafoggia M, Sozzi R, Davoli M, Forastiere F. Long-
Term Exposure to Urban Air Pollution and Mortality in a Cohort of More than A Million Adults
in Rome. Environ Health Perspect. 2013 Jan 8. [Epub ahead of print]
Shields KN, Cavallari JM, Hunt MJ, Lazo M, Molina M, Molina L, Holguin F. Trafficrelated
air pollution exposures and changes in heart rate variability in Mexico City: A panel
study. Environ Health. 2013 Jan 18;12(1):7. [Epub ahead of print]
Wichmann J, Folke F, Torp-Pedersen C, Lippert F, Ketzel M, Ellermann T, Loft S. Out-of-
Hospital Cardiac Arrests and Outdoor Air Pollution Exposure in Copenhagen, Denmark. PLoS
One. 2013;8(1):e53684. doi: 10.1371/journal.pone.0053684. Epub 2013 Jan 14.
Perez CM, Ledbetter AD, Hazari MS, Hayak-Coates N, Carll AP, Winsett DW, Costa DL,
Farraj AK. Hypoxia Stress Test Reveals Exaggerated Cardiovascular Effects in Hypertensive
Rats after Exposure to the Air Pollutant Acrolein. Toxicol Sci. 2013 Jan 18. [Epub ahead of
print]
Rosenthal FS, Kuisma M, Lanki T, Hussein T, Boyd J, Halonen JI, Pekkanen J. Association
of ozone and particulate air pollution with out-of-hospital cardiac arrest in Helsinki, Finland:
Evidence for two different etiologies. J Expo Sci Environ Epidemiol. 2013 Jan 30. doi: 10.1038/
jes.2012.121. [Epub ahead of print]
Rivera M, Basagaña X, Aguilera I, Foraster M, Agis D, de Groot E, Perez L, Mendez MA,
Bouso L, Targa J, Ramos R, Sala J, Marrugat J, Elosua R, Künzli N. Association between Long-
Term Exposure to Traffic-Related Air Pollution and Subclinical Atherosclerosis: The REGICOR
Study. Environ Health Perspect. 2013 Feb; 121(2):223-30. doi: 10.1289/ehp.1205146. Epub
2012 Dec 11.
Ensor KB, Raun LH, Persse D. A Case-Crossover Analysis of Out-of-Hospital Cardiac
Arrest and Air Pollution. Circulation. 2013 Feb 13. [Epub ahead of print]
Tonne C, Wilkinson P. Long-term exposure to air pollution is associated with survival
following acute coronary syndrome. European Heart Journal, 2013 DOI: 10.1093/eurheartj/
ehs480
111.Mannucci PM. Airborne pollution and cardiovascular disease: burden and causes of an
16
epidemic. European Heart Journal, 2013 DOI: 10.1093/eurheartj/eht045
Krishnan RM, Sullivan JH, Carlsten C, Wilkerson HW, Beyer RP, Bammler T, Farin F,
Peretz A, Kaufman JD. A randomized cross-over study of inhalation of diesel exhaust,
hematological indices, and endothelial markers in humans. Part Fibre Toxicol. 2013 Mar
26;10(1):7. [Epub ahead of print]
Pedata P, Bergamasco N, D’Anna A, Minutolo P, Servillo L, Sannolo N, Balestrieri ML.
Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in
endothelial cells. Toxicol Lett. 2013 Mar 25. pii: S0378-4274(13)00122-7. doi: 10.1016/j.toxlet.
2013.03.017. [Epub ahead of print]
Xu X, Sun Y, Ha S, Talbott EO, Lissaker CT. Association between Ozone Exposure and
Onset of Stroke in Allegheny County, Pennsylvania, USA, 1994-2000. Neuroepidemiology. 2013
Mar 20;41(1):2-6. [Epub ahead of print]
Yin F, Lawal A, Ricks J, Fox JR, Larson T, Navab M, Fogelman AM, Rosenfeld ME,
Araujo JA. Diesel Exhaust Induces Systemic Lipid Peroxidation and Development of
Dysfunctional Pro-Oxidant and Proinflammatory High-Density Lipoprotein. Arterioscler
Thromb Vasc Biol. 2013 Apr 4. [Epub ahead of print]
Carlsen H, Forsberg B, Meister K, Gíslason T, Oudin A. Ozone is associated with
cardiopulmonary and stroke emergency hospital visits in Reykjavik, Iceland 2003–2009.
Environmental Health 2013, 12:28 doi:10.1186/1476-069X-12-28
Xiang H, Mertz KJ, Arena VC, Brink LL, Xu X, Bi Y, Talbott EO. Estimation of short-term
effects of air pollution on stroke hospital admissions in wuhan, china. PLoS One. 2013 Apr
12;8(4):e61168. doi: 10.1371/journal.pone.0061168. Print 2013.
Carey IM, Atkinson RW, Kent AJ, van Staa T, Cook DG, Anderson HR. Mortality
Associations with Long-Term Exposure to Outdoor Air Pollution in a National English Cohort.
Am J Respir Crit Care Med. 2013 Apr 3. [Epub ahead of print]
Chang CC, Kuo CC, Liou SH, Yang CY. Fine particulate air pollution and hospital
admissions for myocardial infarction in a subtropical city: taipei, taiwan. J Toxicol Environ
Health A. 2013;76(7):440-8. doi: 10.1080/15287394.2013.771559.
Yu IT, Qiu H, Wang X, Tian L, Tse LA. Synergy between particles and nitrogen dioxide on
emergency hospital admissions for cardiac diseases in Hong Kong. Int J Cardiol. 2013 Apr 19.
pii: S0167-5273(13)00513-5. doi: 10.1016/j.ijcard.2013.03.082. [Epub ahead of print]
Adar SD, Sheppard L, Vedal S, Polak JF, Sampson PD, et al. (2013) Fine Particulate Air
Pollution and the Progression of Carotid Intima-Medial Thickness: A Prospective Cohort Study
from the Multi-Ethnic Study of Atherosclerosis and Air Pollution. PLoS Med 10(4): e1001430.
doi:10.1371/journal.pmed.1001430
Son JY, Lee JT, Park YH, Bell ML. Short-Term Effects of Air Pollution on Hospital
17
Admissions in Korea. Epidemiology. 2013 May 14. [Epub ahead of print]
Kloog I, Ridgway B, Koutrakis P, Coull BA, Schwartz JD. Long- and Short-Term Exposure
to PM2.5 and Mortality Using Novel Exposure Models. Epidemiology. 2013 May 14. [Epub
ahead of print]
Wittkopp S, Staimer N, Tjoa T, Gillen D, Daher N, Shafer M, Schauer JJ, Sioutas C,
Delfino RJ. Mitochondrial Genetic Background Modifies the Relationship between Traffic-
Related Air Pollution Exposure and Systemic Biomarkers of Inflammation. PLoS One. 2013
May 23;8(5):e64444. doi: 10.1371/journal.pone.0064444. Print 2013.
Unosson J, Blomberg A, Sandström T, Muala A, Boman C, Nyström R, Westerholm R, Mills
NL, Newby DE, Langrish JP, Bosson JA. Exposure to wood smoke increases arterial stiffness
and decreases heart rate variability in humans. Part Fibre Toxicol. 2013 Jun 6;10(1):20. [Epub
ahead of print]
Stafoggia M, Samoli E, Alessandrini E, Cadum E, Ostro B, Berti G, Faustini A, Jacquemin
B, Linares C, Pascal M, Randi G, Ranzi A, Stivanello E, Forastiere F. Short term Associations
between Fine and Coarse Particulate Matter and Hospitalizations in Southern Europe: Results
from the MED-PARTICLES Project. Environ Health Perspect. 2013 Jun 18. [Epub ahead of
print]
Koton S, Molshatzki N, Yuval, Myers V, Broday DM, Drory Y, Steinberg DM, Gerber Y.
Cumulative exposure to particulate matter air pollution and long-term post- myocardial
infarction outcomes. Prev Med. 2013 Jun 15. pii: S0091-7435(13)00201-6. doi: 10.1016/
j.ypmed.2013.06.009. [Epub ahead of print]
Pope CA 3rd, Dockery DW. Air pollution and life expectancy in China and beyond. Proc
Natl Acad Sci U S A. 2013 Jul 11
Shah ASV, Langrish JP, Nair H, et al. Global association of air pollution and heart failure:
a systematic review and meta-analysis. The Lancet. Published online July 10 2013
Chena Y, Ebensteinb A, Greenstone M, Lie H. Evidence on the impact of sustained
exposure to air pollution on life expectancy from China’s Huai River policy. www.pnas.org/cgi/
doi/10.1073/pnas.1300018110
Louwies T, Panis L, Kicinski M, De Boever P, Nawrot TS. Retinal Microvascular
Responses to Short-Term Changes in Particulate Air Pollution in Healthy Adults. Environ
Health Perspect. 2013 Jun 18. [Epub ahead of print]
Brugge D, et al. Highway proximity associated with cardiovascular disease risk: the
influence of individual-level confounders and exposure misclassification. Environmental Health
2013, 12:84 doi:10.1186/1476-069X-12-84 Published: 3 October 2013
Straney L, Finn J, Dennekamp M, Bremner A, Tonkin A, Jacobs I. Evaluating the impact of
air pollution on the incidence of out-of-hospital cardiac arrest in the Perth Metropolitan
18
Region: 2000-2010. J Epidemiol Community Health. 2013 Sep 17. doi: 10.1136/
jech-2013-202955. [Epub ahead of print]
Bilenko N, Rossem LV, Brunekreef B, Beelen R, Eeftens M, Hoek G, Houthuijs D, de
Jongste JC, Kempen EV, Koppelman GH, Meliefste K, Oldenwening M, Smit HA, Wijga AH,
Gehring U. Traffic-related air pollution and noise and children’s blood pressure: results from
the PIAMA birth cohort study. Eur J Prev Cardiol. 2013 Sep 18. [Epub ahead of print]
Krall JR, GB Anderson, F Dominici, ML Bel, RD Peng. Short-term exposure to particulate
matter constituents and mortality in a national study of U.S. urban communities. 2013. http://
ehp.niehs.nih.gov/1206185/. Environmental Health Perspectives; http://dx.doi.org/10.1289/ehp.
1206185.
Meng X, Ma Y, Chen R, Zhou Z, Chen B, Kan H. Size-Fractionated Particle Number
Concentrations and Daily Mortality in a Chinese City. Environ Health Perspect. 2013 Aug 13.
[Epub ahead of print]
Neuberger M, Moshammer H, Rabczenko D. Acute and subacute effects of urban air
pollution on cardiopulmonary emergencies and mortality: time series studies in austrian cities.
Int J Environ Res Public Health. 2013 Oct 2;10(10):4728-51. doi: 10.3390/ijerph10104728.
Kälsch H, Hennig F, Moebus S, Möhlenkamp S, Dragano N, Jakobs H, Memmesheimer M,
Erbel R, Jöckel KH, Hoffmann B. Are air pollution and traffic noise independently associated
with atherosclerosis: theHeinz Nixdorf Recall Study. Eur Heart J. 2013 Nov 4. [Epub ahead of
print]
Mehta AJ, Zanobetti A, Koutrakis P, Mittleman MA, Sparrow D, Vokonas P, Schwartz J.
Associations Between Short-term Changes in Air Pollution and Correlates of Arterial Stiffness:
The Normative Aging Study, 2007-2011. Am J Epidemiol. 2013 Nov 13. [Epub ahead of print]
Neophytou AM, Hart JE, Cavallari JM, Smith TJ, Dockery DW, Coull BA, Garshick E,
Laden F. Traffic-related exposures and biomarkers of systemic inflammation, endothelial
activation and oxidative stress: a panel study in the US trucking industry. Environ Health. 2013
Dec 7;12(1):105. [Epub ahead of print]
Guo Y, Li S, Tian Z, Pan X, Zhang J, Williams G. The burden of air pollution on years of
life lost in Beijing, China, 2004-08: retrospective regression analysis of daily deaths. BMJ. 2013
Dec 9;347:f7139. doi: 10.1136/bmj.f7139.
Villarreal-Calderon R, Franco-Lira M, González-Maciel A, Reynoso-Robles R, Harritt L,
Pérez-Guillé B, Ferreira-Azevedo L, Drecktrah D, Zhu H, Sun Q, Torres-Jardón R, Aragón-
Flores M, Calderón-Garcidueñas A, Diaz P, Calderón-Garcidueñas L. Up- Regulation of mRNA
Ventricular PRNP Prion Protein Gene Expression in Air Pollution Highly Exposed Young
Urbanites: Endoplasmic Reticulum Stress, Glucose Regulated Protein 78, and Nanosized
Particles. Int J Mol Sci. 2013 Nov 28;14(12):23471-91. doi: 10.3390/ijms141223471
19
Gardner B, Ling F, Hopke PK, Frampton MW, Utell MJ, Zareba W, Cameron SJ, Chalupa
D, Kane C, Kulandhaisamy S, Topf MC, Rich DQ. Ambient fine particulate air pollution
triggers ST-elevation myocardial infarction, but not non-ST elevation myocardial infarction: a
case-crossover study. Part Fibre Toxicol. 2014 Jan 2;11(1):1. [Epub ahead of print]
Wu Z, He EY, Scott GI, Ren J. α,β-Unsaturated aldehyde pollutant acrolein suppresses
cardiomyocyte contractile function: Role of TRPV1 and oxidative stress. Environ Toxicol. 2013
Dec 23. doi: 10.1002/tox.21941. [Epub ahead of print]
Zanobetti A, et al. Brachial Artery Responses to Ambient Pollution, Temperature, and
Humidity in People with Type 2 Diabetes: A Repeated-Measures Study. Environ Health
Perspect; DOI:10.1289/ehp.1206136
Zhao X, Sun Z, Ruan Y, Yan J, Mukherjee B, Yang F, Duan F, Sun L, Liang R, Lian H,
Zhang S, Fang Q, Gu D, Brook JR, Sun Q, Brook RD, Rajagopalan S, Fan Z. Personal Black
Carbon Exposure Influences Ambulatory Blood Pressure: Air Pollution and Cardiometabolic
Disease (AIRCMD-China) Study. Hypertension. 2014 Jan 13. [Epub ahead of print]
Cesaroni G, et al. Long term exposure to ambient air pollution and incidence of acute
coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the
ESCAPE Project
BMJ 2014;348:f7412
Beelen R, Raaschou-Nielsen O, Stafoggia M, et al. Effects of long-term exposure to air
pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre
ESCAPE project. The Lancet. Published online December 9 2013
Gall S, et al. Exposure to parental smoking in childhood or adolescence is associated with
increased carotid intima-media thickness in young adults: evidence from the Cardiovascular
Risk in Young Finns study and the Childhood Determinants of Adult Health Study Eur Heart J
first published online March 4, 2014 doi:10.1093/ eurheartj/ehu049
Shaposhnikov D, et al. Mortality Related to Air Pollution with the Moscow Heat Wave and
Wildfire of 2010. Epidemiology. 2014 Mar 4. [Epub ahead of print]
Huang YL, Chen HW, Han BC, Liu CW, Chuang HC, Lin LY, Chuang KJ. Personal
Exposure to Household Particulate Matter, Household Activities and Heart Rate Variability
among Housewives. PLoS One. 2014 Mar 3;9(3):e89969. doi: 10.1371/ journal.pone.0089969.
eCollection 2014.
Beelen R. Long-term Exposure to Air Pollution and Cardiovascular Mortality: An Analysis
of 22 European Cohorts. Epidemiology. 2014 Feb 28. [Epub ahead of print]
Brook RD, Bard RL, Morishita M, Dvonch JT, Wang L, Yang HY, Spino C, Mukherjee B,
Kaplan MJ, Yalavarthi S, Oral EA, Ajluni N, Sun Q, Brook JR, Harkema J, Rajagopalan S.
Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air
20
Pollution from a Rural Location. Environ Health Perspect. 2014 Mar 11. [Epub ahead of print]
Jevtić M, Dragić N, Bijelović S, Popović M. Cardiovascular diseases and air pollution in
Novi Sad, Serbia. Int J Occup Med Environ Health. 2014 Feb 18. [Epub ahead of print]
Babisch W, Wolf K, Petz M, Heinrich J, Cyrys J, and Peters A. Associations between
Traffic Noise, Particulate Air Pollution, Hypertension, and Isolated Systolic Hypertension in
Adults: The KORA Study. Environ Health Perspect; DOI:10.1289/ehp. 1306981
Devlin RB, Smith CB, Schmitt MT, Rappold AG, Hinderliter A, Graff D, Carraway MS.
Controlled Exposure of Humans with Metabolic Syndrome to Concentrated Ultrafine Ambient
Particulate Matter Causes Cardiovascular Effects. Toxicol Sci. 2014 Apr 9. [Epub ahead of
print]
Dai L, Zanobetti A, Koutrakis P, Schwartz JD. Associations of Fine Particulate Matter
Species with Mortality in the United States: A Multicity Time-Series Analysis. Environ Health
Perspect. 2014 May 6. [Epub ahead of print]
Yu XB, Su JW, Li XY, Chen G. Short-term effects of particulate matter on stroke attack:
meta-regression and meta-analyses. PLoS One. 2014 May 6;9(5):e95682. doi: 10.1371/
journal.pone.0095682. eCollection 2014.
Hendryx M, Luo J, Chen BC. Total and cardiovascular mortality rates in relation to
discharges from toxics release inventory sites in the United States. Environ Res. 2014 Jun
3;133C:36-41. doi: 10.1016/j.envres.2014.05.010. [Epub ahead of print]
Brook R, et al. Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse
Particulate Matter Air Pollution from a Rural Location. Environ Health Perspect; DOI:
10.1289/ehp.1306595
Saber AT, Jacobsen NR, Jackson P, Poulsen SS, Kyjovska ZO, Halappanavar S, Yauk CL,
Wallin H, Vogel U. Particle-induced pulmonary acute phase response may be the causal link
between particle inhalation and cardiovascular disease. Wiley Interdiscip Rev Nanomed
Nanobiotechnol. 2014 Jun 12. doi: 10.1002/wnan.1279. [Epub ahead of print]
Vora R, Zareba W, Utell MJ, Pietropaoli AP, Chalupa D, Little EL, Oakes D, Bausch J,
Wiltshire J, Frampton MW. Inhalation of ultrafine carbon particles alters heart rate and heart
rate variability in people with type 2 diabetes. Part Fibre Toxicol. 2014 Jul 16;11(1):31. [Epub
ahead of print]
Nyhan M, McNabola A, Misstear B. Comparison of particulate matter dose and acute heart
rate variability response in cyclists, pedestrians, bus and train passengers. Sci Total Environ.
2014 Jan 15;468-469:821-31. doi: 10.1016/j.scitotenv.2013.08.096. Epub 2013 Sep 25.
Multiple exposures to airborne pollutants and hospital admissions due to diseases of the
circulatory system in Santiago de Chile. Sci Total Environ. 2014 Jan 15;468-469:746-56. doi:
10.1016/j.scitotenv.2013.08.088. Epub 2013 Sep 23.
21
Chalbot MC, Jones TA, Kavouras IG. Trends of Non-Accidental, Cardiovascular, Stroke
and Lung Cancer Mortality in Arkansas Are Associated with Ambient PM2.5 Reductions. Int J
Environ Res Public Health. 2014 Jul 21;11(7):7442-7455.
Dai L, Zanobetti A, Koutrakis P, Schwartz J. Associations of Fine Particulate Matter
Species with Mortality in the United States: A Multicity Time-Series Analysis. Environ Health
Perspect; DOI:10.1289/ehp.1307568
Kim SY, Sheppard L, Kaufman JD, Bergen S, Szpiro AA, Larson TV, Adar SD, Diez Roux
AV, Polak JF, Vedal S. Individual-Level Concentrations of Fine Particulate Matter Chemical
Components and Subclinical Atherosclerosis: A Cross-Sectional Analysis Based on 2 Advanced
Exposure Prediction Models in the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol. 2014
Aug 26. pii: kwu186. [Epub ahead of print]
Rich DQ, Mittleman MA, Link MS, Schwartz J, Luttmann-Gibson H, Catalano PJ, Speizer
FE, Gold DR, Dockery DW. Increased Risk of Paroxysmal Atrial Fibrillation Episodes
Associated with Acute Increases in Ambient Air Pollution. Environ Health Perspect. 2006;
114:120-123.
Rao X, Zhong J, Maiseyeu A, Gopalakrishnan B, Villamena FA, Chen LC, Harkema JR,
Sun Q, Rajagopalan S. CD36-Dependent 7-Ketocholesterol Accumulation in Macrophages
Mediates Progression of Atherosclerosis in Response to Chronic Air Pollution Exposure. Circ
Res. 2014 Sep 3. pii: CIRCRESAHA.114.304666. [Epub ahead of print]
Dong GH, Qian ZM, Trevathan E, Zeng XW, Vaughn MG, Wang J, Zhao Y, Liu YQ, Ren
WH, Qin XD. Air pollution associated hypertension and increased blood pressure may be
reduced by breastfeeding in Chinese children: The Seven Northeastern Cities Chinese
Children’s Study. Int J Cardiol. 2014 Aug 26. pii: S0167-5273(14)01644-1. doi: 10.1016/
j.ijcard. 2014.08.099. [Epub ahead of print]
Karottki DG, Bekö G, Clausen G, Madsen AM, Andersen ZJ, Massling A, Ketzel M,
Ellermann T, Lund R, Sigsgaard T, Møller P, Loft S. Cardiovascular and lung function in
relation to outdoor and indoor exposure to fine and ultrafine particulate matter in middle- aged
subjects. Environ Int. 2014 Sep 15;73C:372-381. doi: 10.1016/j.envint. 2014.08.019. [Epub
ahead of print]
Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q,
Harkema JR, Rajagopalan S, Brook RD. The characteristics of coarse particulate matter air
pollution associated with alterations in blood pressure and heart rate during controlled
exposures. J Expo Sci Environ Epidemiol. 2014 Sep 17. doi: 10.1038/jes. 2014.62. [Epub ahead
of print]
Cakmak S, Kauri L, Shutt R, Liu L, Green MS, Mulholland M, Stieb D, Dales R. The
association between ambient air quality and cardiac rate and rhythm in ambulatory subjects.
22
Environ Int. 2014 Sep 13;73C:365-371. doi: 10.1016/j.envint.2014.08.015. [Epub ahead of
print]
Baumgartner J, et al. Highway proximity and black carbon from cookstoves as a risk factor
for higher blood pressure in rural China. PNAS, August 2014 DOI: 10.1073/ pnas.1317176111
Wauters A, Esmaeilzadeh F, Bladt S, Beukinga I, Wijns W, van de Borne P, Pradier O,
Argacha JF. Pro-thrombotic effect of exercise in a polluted environment: a P- selectin- and
CD63-related platelet activation effect. Thromb Haemost. 2014 Oct 9;113(1). [Epub ahead of
print]
Talbott EO, Rager JR, Benson S, Ann Brink L, Bilonick RA, Wu C. A case- crossover
analysis of the impact of PM2.5 on cardiovascular disease hospitalizations for selected CDC
tracking states.
Environ Res. 2014 Sep 29;134C:455-465. doi: 10.1016/j.envres.2014.06.018. [Epub ahead of
print]
Evans JM, Jenkins RA, Ilgner RH, Knapp CF, Zhang Q, Patwardhan AR. Acute
cardiovascular autonomic responses to inhaled particulates. Eur J Appl Physiol. 2014 Oct 2.
[Epub ahead of print]
Morishita M, Bard RL, Wang L, Das R, Dvonch JT, Spino C, Mukherjee B, Sun Q,
Harkema JR, Rajagopalan S, Brook RD. The characteristics of coarse particulate matter air
pollution associated with alterations in blood pressure and heart rate during controlled
exposures. J Expo Sci Environ Epidemiol. 2014 Sep 17. doi: 10.1038/jes. 2014.62. [Epub ahead
of print]
Schulz AJ, Mentz GB, Sampson NR, Dvonch JT, Reyes AG, Izumi B. Effects of Particulate
Matter and Antioxidant Dietary Intake on Blood Pressure. Am J Public Health. 2014 Oct 16:e1-
e8. [Epub ahead of print]
Kurhanewicz N, McIntosh-Kastrinsky R, Tong H, Walsh L, Farraj A, Hazari MS. Ozone coexposure
modifies cardiac responses to fine and ultrafine ambient particulate matter in mice:
concordance of electrocardiogram and mechanical responses. Part Fibre Toxicol. 2014 Oct
16;11(1):54. [Epub ahead of print]
Pope CA, Turner MC, Burnett R, Jerrett M, Gapstur SM, Diver WR, Krewski D, Brook RD.
Relationships Between Fine Particulate Air Pollution, Cardiometabolic Disorders and
Cardiovascular Mortality. Circ Res. 2014 Oct 27. pii: CIRCRESAHA. 114.305060. [Epub ahead
of print]
Xie W, et al. Relationship between fine particulate air pollution and ischaemic heart
disease morbidity and mortality. Heart. 2014 Oct 23. pii: heartjnl-2014-306165. doi: 10.1136/
heartjnl-2014-306165. [Epub ahead of print]
Hart JE, Chiuve SE, Laden F, Albert CM. Roadway proximity and risk of sudden cardiac
23
death in women. Circulation. 2014 Oct 21;130(17):1474-82. doi: 10.1161/
CIRCULATIONAHA.114.011489. Epub 2014 Oct 13.
Yorifuji T, et al. Outdoor Air Pollution and Out-of-Hospital Cardiac Arrest in Okayama,
Japan. Journal of Occupational and Environmental Medicine, 2014; 56 (10): 1019 DOI:
10.1097/JOM.0000000000000274
Zhang X, Chen Y, Wei H, Qin Y, Hao Y, Zhu Y, Deng F, Guo X. Ultrafine carbon black
attenuates the antihypertensive effect of captopril in spontaneously hypertensive rats. Inhal
Toxicol. 2014 Dec;26(14):853-60. doi: 10.3109/08958378.2014.965558.
Xie W, et al. Relationship between fine particulate air pollution and ischaemic heart
disease morbidity and mortality. Heart. 2014 Oct 23. pii: heartjnl-2014-306165. doi: 10.1136/
heartjnl-2014-306165. [Epub ahead of print]
Olsen Y, Karottki DG, Jensen DM, Bekö G, Kjeldsen BU, Clausen G, Hersoug LG, Holst
GJ, Wierzbicka A, Sigsgaard T, Linneberg A, Møller P, Loft S. Vascular and lung function
related to ultrafine and fine particles exposure assessed by personal and indoor monitoring: a
cross-sectional study. Environ Health. 2014 Dec 15;13(1):112. [Epub ahead of print]
Weichenthal S, Hatzopoulou M, Goldberg MS. Exposure to traffic-related air pollution
during physical activity and acute changes in blood pressure, autonomic and micro-vascular
function in women: a cross-over study. Part Fibre Toxicol. 2014 Dec 9;11(1):70. [Epub ahead
of print]
Gorr MW , et al. Early life exposure to air pollution induces adult cardiac dysfunction.
American Journal of Physiology – Heart and Circulatory PhysiologyPublished 1 November
2014Vol. 307no. 9, H1353-H1360DOI: 10.1152/ ajpheart.00526.2014
Chung Y, Dominici F, Wang Y, Coull BA, Bell ML. Associations between Long- Term
Exposure to Chemical Constituents of Fine Particulate Matter (PM2.5) and Mortality in
Medicare Enrollees in the Eastern United States. Environ Health Perspect. 2015 Jan 6. [Epub
ahead of print]
Environ Pollut. 2015 Feb 9;199C:192-197. doi: 10.1016/j.envpol.2015.02.002. [Epub
ahead of print]. Air pollution and mortality: Effect modification by personal characteristics and
specific cause of death in a case-only study.
Kloog I, Zanobetti A, Nordio F, Coull BA, Baccarelli AA, Schwartz J. Effects of airborne
fine particles (PM2.5) on Deep Vein Thrombosis Admissions in North Eastern United States. J
Thromb Haemost. 2015 Feb 12. doi: 10.1111/jth.12873. [Epub ahead of print]
Li R, Kou X, Geng H, Xie J, Tian J, Cai Z, Dong C. Mitochondrial damage: An important
mechanism of ambient PM2.5 exposure-induced acute heart injury in rats. J Hazard Mater.
2015 Feb 4;287C:392-401. doi: 10.1016/j.jhazmat.2015.02.006. [Epub ahead of print]
Faustini A, Alessandrini ER, Pey J, Perez N, Samoli E, Querol X, Cadum E, Perrino C,
24
Ostro B, Ranzi A, Sunyer J, Stafoggia M, Forastiere F Short-term effects of particulate matter
on mortality during forest fires in Southern Europe: results of the MED-PARTICLES Project.
Occup Environ Med. 2015 Feb 17. pii: oemed-2014-102459. doi: 10.1136/oemed-2014-102459.
[Epub ahead of print]
Pope CA 3rd, Turner MC, Burnett RT, Jerrett M, Gapstur SM, Diver WR, Krewski D,
Brook RD. Relationships between fine particulate air pollution, cardiometabolic disorders, and
cardiovascular mortality. Circ Res. 2015 Jan 2;116(1):108-15. doi: 10.1161/CIRCRESAHA.
116.305060. Epub 2014 Oct 27.
Su TC, Hwang JJ, Shen YC, Chan CC. Carotid Intima-Media Thickness and Long-Term
Exposure to Traffic-Related Air Pollution in Middle-Aged Residents of Taiwan: A Cross-
Sectional Study.
Environ Health Perspect. 2015 Mar 20. [Epub ahead of print]
Chen SY, Wu CF, Lee JH, Hoffmann B, Peters A, Brunekreef B, Chu DC, Chan CC.
Associations between Long-Term Air Pollutant Exposures and Blood Pressure in Elderly
Residents of Taipei City: A Cross-Sectional Study. Environ Health Perspect. 2015 Mar 20.
[Epub ahead of print]
Burroughs Peña M, Romero KM, Velazquez EJ, Davila-Roman VG, Gilman RH, Wise RA,
Miranda JJ, Checkley W. Relationship Between Daily Exposure to Biomass Fuel Smoke and
Blood Pressure in High-Altitude Peru. Hypertension. 2015 Mar 9. pii: HYPERTENSIONAHA.
114.04840. [Epub ahead of print]
Chan S, et al. Long-Term Air Pollution Exposure and Blood Pressure in the Sister Study.
Environ Health Perspect; DOI:10.1289/ehp.1408125
Pieters N, et al. Blood Pressure and Same-Day Exposure to Air Pollution at School:
Associations with Nano-Sized to Coarse PM in Children. Environ Health Perspect; DOI:
10.1289/ehp.1408121
ChenR,ZhaoZ,SunQ,LinZ,ZhaoA,WangC,XiaY,XuX,KanH. Size- fractionated Particulate
Air Pollution and Circulating Biomarkers of Inflammation, Coagulation, and Vasoconstriction
in a Panel of Young Adults. Epidemiology. 2015 Feb 25. [Epub ahead of print]
Chung M, Wang DD, Rizzo AM, Gachette D, Delnord M, Parambi R, Kang CM, Brugge D.
Association of PNC, BC, and PM2.5 Measured at a Central Monitoring Site with Blood
Pressure in a Predominantly Near Highway Population. Int J Environ Res Public Health. 2015
Mar 3;12(3):2765-80. doi: 10.3390/ijerph120302765.
Ostro B, et al. Associations of Mortality with Long-Term Exposures to Fine and Ultrafine
Particles, Species and Sources: Results from the California Teachers Study Cohort.
Environmental Health Perspectives, http://dx.doi.org/10.1289/ehp.1408565. Advance
Publication: 23 January 201
25
Fischer PH, Marra M, Ameling CB, Hoek G, Beelen R, de Hoogh K, Breugelmans O,
Kruize H, Janssen NA, Houthuijs D. Air Pollution and Mortality in Seven Million Adults: The
Dutch Environmental Longitudinal Study (DUELS). Environ Health Perspect. 2015 Mar 11.
[Epub ahead of print]
van Rossem L, et al. Prenatal Air Pollution Exposure and Newborn Blood Pressure.
Environ Health Perspect; DOI:10.1289/ehp.1307419
Zhao A, Chen R, Wang C, Zhao Z, Yang C, Lu J, Chen X, Kan H. Associations between
size-fractionated particulate air pollution and blood pressure in a panel of type II diabetes
mellitus patients. Environ Int. 2015 Mar 30;80:19-25. doi: 10.1016/j.envint.2015.03.003. [Epub
ahead of print]
Wong CM, Lai HK, Tsang H, Thach TQ, Thomas GN, Lam KB, Chan KP, Yang L, Lau AK,
Ayres JG, Lee SY, Chan WM, Hedley AJ, Lam TH. Satellite-Based Estimates of Long-Term
Exposure to Fine Particles and Association with Mortality in Elderly Hong Kong Residents.
Environ Health Perspect. 2015 Apr 24. [Epub ahead of print]
Dominici F, Wang Y, Correia AW, Ezzati M, Pope CA 3rd, Dockery DW. Chemical
Composition of Fine Particulate Matter and Life Expectancy: In 95 US Counties Between 2002
and 2007. Epidemiology. 2015 Apr 22. [Epub ahead of print]
Shi L, et al. Low-Concentration PM2.5 and Mortality: Estimating Acute and Chronic
Effects in a Population-Based Study. Environ Health Perspect DOI: 10.1289/ ehp.1409111
Wolf K, et al. Long-term Exposure to Particulate Matter Constituents and the Incidence of
Coronary Events in 11 European Cohorts. Epidemiology. 2015 May 14. [Epub ahead of print]
Andersen ZA, et al. A Study of the Combined Effects of Physical Activity and Air Pollution
on Mortality in Elderly Urban Residents: The Danish Diet, Cancer, and Health Cohort. Environ
Health Perspect; DOI:10.1289/ehp.1408698
Akintoye E, et al. Association between fine particulate matter exposure and subclinical
atherosclerosis: A meta-analysis. Eur J Prev Cardiol. 2015 May 29. pii: 2047487315588758.
[Epub ahead of print]
ResBart Ostro R. et al. Associations of Mortality with Long-Term Exposures to Fine and
Ultrafine Particles, Species and Sources: Environ Health Perspect; DOI: 10.1289/ehp.1408565
Ta-Chen Su, et al. Carotid Intima-Media Thickness and Long-Term Exposure to Traffic-
Related Air Pollution in Middle-Aged Residents of Taiwan: A Cross-Sectional Study. Environ
Health Perspect; DOI:10.1289/ehp.1408553
Szu-Ying C, et al. Associations between Long-Term Air Pollutant Exposures and Blood
Pressure in Elderly Residents of Taipei City: A Cross-Sectional Study. Environ Health Perspect;
DOI:10.1289/ehp.1408771
Szu-Ying C, et al. Associations between Long-Term Air Pollutant Exposures and Blood
26
Pressure in Elderly Residents of Taipei City: A Cross-Sectional Study. Environ Health Perspect;
DOI:10.1289/ehp.1408771
Bangia K, Symanski E, Strom SS, Bondy M. A cross-sectional analysis of polycyclic
aromatic hydrocarbons and diesel particulate matter exposures and hypertension among
individuals of Mexican origin. Environ Health. 2015 Jun 12;14(1): 51. [Epub ahead of print]
Fischer P, et al. Air Pollution and Mortality in Seven Million Adults: The Dutch
Environmental Longitudinal Study (DUELS) Environ Health Perspect; DOI: 10.1289/ehp.
1408254
Schwartz J, Austin E, Bind MA, Zanobetti A, Koutrakis P. Estimating Causal Associations
of Fine Particles With Daily Deaths in Boston. Am J Epidemiol. 2015 Sep 6. pii: kwv101. [Epub
ahead of print]
Lee M, Koutrakis P, Coull B, Kloog I, Schwartz J. Acute effect of fine particulate matter
on mortality in three Southeastern states from 2007-2011. J Expo Sci Environ Epidemiol. 2015
Aug 26. doi: 10.1038/jes.2015.47. [Epub ahead of print]
Giorgini P, Rubenfire M, Bard RL, Jackson EA, Ferri C, Brook RD. Air Pollution and
Exercise: A REVIEW OF THE CARDIOVASCULAR IMPLICATIONS FOR HEALTH CARE
PROFESSIONALS. J Cardiopulm Rehabil Prev. 2015 Sep 16. [Epub ahead of print]
Wu S, Deng F, Huang J, Wang X, Qin Y, Zheng C, Wei H, Shima M, Guo X. Does ambient
temperature interact with air pollution to alter blood pressure? A repeated-measure study in
healthy adults. J Hypertens. 2015 Sep 16. [Epub ahead of print]
Vodonos A, et al. Individual Effect Modifiers of Dust Exposure Effect on Cardiovascular
Morbidity. PLoS One. 2015 Sep 18;10(9):e0137714. doi: 10.1371/journal.pone.0137714.
Crouse D, et al. Ambient PM2.5, O3, and NO2 Exposures and Associations with Mortality
over 16 Years of Follow-Up in the Canadian Census Health and Environment Cohort
(CanCHEC). Environ Health Perspect; DOI:10.1289/ehp.1409276
Powell H, et al. Ambient Coarse Particulate Matter and Hospital Admissions in the
Medicare Cohort Air Pollution Study, 1999-2010. Environ Health Perspect; DOI:10.1289/ehp.
1408720
Lin H, et al. Particle size and chemical constituents of ambient particulate pollution
associated with cardiovascular mortality in Guangzhou, China. Environ Pollut. 2015 Nov 8.
pii: S0269-7491(15)30156-1. doi: 10.1016/j.envpol.2015.10.056. [Epub ahead of print]
Liu W, et al. The association of annual air pollution exposure with blood pressure among
patients with sleep-disordered breathing. Sci Total Environ. 2015 Nov 12;543(Pt A):61-66. doi:
10.1016/j.scitotenv.2015.10.135. [Epub ahead of print]
Kang SH, et al. Ambient air pollution and out-of-hospital cardiac arrest. Int J Cardiol.
2015 Nov 18;203:1086-1092. doi: 10.1016/j.ijcard.2015.11.100. [Epub ahead of print]
27
Broome RA, et al. The mortality effect of ship-related fine particulate matter in the Sydney
greater metropolitan region of NSW, Australia. Environ Int. 2015 Nov 28;87:85-93. doi:
10.1016/j.envint.2015.11.012. [Epub ahead of print]
Caiazzo F, et al. Air pollution and early deaths in the United States. Part I: Quantifying
the impact of major sectors in 2005. Atmospheric Environment. Volume 79, November 2013,
Pages 198–208
Thurston GD, Burnett RT, Turner MC, Shi Y, Krewski D, Lall R, Ito K, Jerrett M, Gapstur
SM, Diver WR, Pope CA 3rd. Ischemic Heart Disease Mortality and Long-Term Exposure to
Source-Related Components of U.S. Fine Particle Air Pollution. Environ Health Perspect. 2015
Dec 2. [Epub ahead of print]
Van Hee V, et al. Association of Long-Term Air Pollution with Ventricular Conduction
and Repolarization Abnormalities. Epidemiology. 2011 Nov; 22(6): 773–780.
Hart JE, Puett RC, Rexrode KM, Albert CM4, Laden F. Effect Modification of Long-Term
Air Pollution Exposures and the Risk of Incident Cardiovascular Disease in US Women. J Am
Heart Assoc. 2015 Nov 25;4(12). pii: e002301. doi: 10.1161/JAHA.115.002301.
Shanley RP, Hayes RB, Cromar KR, Ito K, Gordon T, Ahn J. “Particulate Air Pollution
and Clinical Cardiovascular Disease Risk Factors”. Epidemiology. 2015 Nov 24. [Epub ahead
of print]
Mordukhovich I, Kloog I, Coull B, Koutrakis P, Vokonas P, Schwartz J. Association
between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort.
Epidemiology. 2015 Nov 24. [Epub ahead of print]
Mentz RJ, O’Brien EC. Air Pollution in Patients With Heart Failure: Lessons From a
Mechanistic Pilot Study of a Filter Intervention. JACC Heart Fail. 2016 Jan;4(1):65-7. doi:
10.1016/j.jchf.2015.11.008.
Meo SA, Suraya F. Effect of environmental air pollution on cardiovascular diseases. Eur
Rev Med Pharmacol Sci. 2015 Dec;19(24):4890-4897.
Sen T, Astarcioglu MA, Asarcikli LD, Kilit C, Kafes H, Parspur A, Yaymaci M, Pinar M,
Tüfekcioglu O, Amasyali. The effects of air pollution and weather conditions on the incidence of
acute myocardial infarction. Am J Emerg Med. 2015 Dec 4. pii: S0735-6757(15)01054-2. doi:
10.1016/j.ajem.2015.11.068. [Epub ahead of print]
Turner MC, et al. Long-Term Ozone Exposure and Mortality in a Large Prospective Study.
Am J Respir Crit Care Med. 2015 Dec 17. [Epub ahead of print]
Weichenthal S, Crouse DL, Pinault L, Godri-Pollitt K, Lavigne E, Evans G, van
Donkelaar A, Martin RV, Burnett RT. Oxidative burden of fine particulate air pollution and risk
of cause-specific mortality in the Canadian Census Health and Environment Cohort
(CanCHEC). Environ Res . 2015 Dec 30;146:92-99. doi: 10.1016/j.envres.2015.12.013. [Epub
28
ahead of print]
Hansell A, et al. Historic air pollution exposure and long-term mortality risks in England
and Wales: prospective longitudinal cohort study. Thorax 2015;0:1–9. doi:10.1136/
thoraxjnl-2015-207111
Cutrufello PT, Rundell KW, Smoliga JM, Stylianides GA. Inhaled whole exhaust and its
effect on exercise performance and vascular function. Inhal Toxicol. 2011 Sep;23(11):658-67.
doi:10.3109/08958378.2011.604106. Epub 2011 Aug 25.
Cakmak S, Dales R, Leech J, Liu L. The influence of air pollution on cardiovascular and
pulmonary function and exercise capacity: Canadian Health Measures Survey (CHMS).
Environ Res. 2011 Nov;111(8):1309-12. doi: 10.1016/j.envres.2011.09.016. Epub 2011 Oct 13.
Thompson LC, et al. Acrolein Inhalation Alters Myocardial Synchrony and Performance
at and Below Exposure Concentrations that Cause Ventilatory Responses. Cardiovasc Toxicol.
2016 Feb 19. [Epub ahead of print]
Bind MA, et al. Quantile Regression Analysis of the Distributional Effects of Air Pollution
on Blood Pressure, Heart Rate Variability, Blood Lipids, and Biomarkers of Inflammation in
Elderly American Men: The Normative Aging Study. Environ Health Perspect. 2016 Mar 11.
[Epub ahead of print]
Vaduganathan M, et al. Risk of Cardiovascular Hospitalizations from Exposure to Coarse
Particulate Matter (PM10) Below the European Union Safety Threshold. Am J Cardiol. 2016
Feb 2. pii: S0002-9149(16)30163-1. doi: 10.1016/j.amjcard.2016.01.041. [Epub ahead of print]
Møller P, et al. Atherosclerosis and vasomotor dysfunction in arteries of animals after
exposure to combustion-derived particulate matter or nanomaterials. Crit Rev Toxicol. 2016
Mar 30:1-40. [Epub ahead of print]
Becerra AZ, et al. Increases in Ambient Particulate Matter Air Pollution, Acute Changes
in Platelet Function, and Effect Modification by Aspirin and Omega-3 Fatty Acids: A Panel
Study. J Toxicol Environ Health A. 2016 Mar 30:1-12. [Epub ahead of print]
Costello S, et al. Incident Ischemic Heart Disease After Long-Term Occupational
Exposure to Fine Particulate Matter: Accounting for 2 Forms of Survivor Bias. Am J
Epidemiol. 2016 Mar 31. pii: kwv218. [Epub ahead of print]
Monrad M, et al. Long-Term Exposure to Traffic-Related Air Pollution and Risk of
Incident Atrial Fibrillation: A Cohort Study. Environ Health Perspect. 2016 Jul 29. [Epub
ahead of print]
Hartiala J, Breton CV, Tang WH, Lurmann F, Hazen SL, Gilliland FD, Allayee H.
Ambient Air Pollution Is Associated With the Severity of Coronary Atherosclerosis and Incident
Myocardial Infarction in Patients Undergoing Elective Cardiac Evaluation. J Am Heart Assoc.
2016 Jul 28;5(8). pii: e003947. doi: 10.1161/JAHA.116.003947.
29
Song X, Liu Y, Hu Y, Zhao X, Tian J, Ding G, Wang S Short-Term Exposure to Air
Pollution and Cardiac Arrhythmia: A Meta-Analysis and Systematic Review. Int J Environ Res
Public Health. 2016 Jun 28;13(7). pii: E642.
Aguilera I, et al. Particulate Matter and Subclinical Atherosclerosis: Associations
between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the
SAPALDIA Study. Environ Health Perspect. 2016 Jun 3. [Epub ahead of print]
Kaufman, J, et al. Association between air pollution and coronary artery calcification
within six metropolitan areas in the USA (the Multi-Ethnic Study of Atherosclerosis and Air
Pollution): a longitudinal cohort study. Lancet. 2016 May 24. pii: S0140-6736(16)00378-0.
doi: 10.1016/S0140-6736(16)00378-0. DOI: http://dx.doi.org/10.1016/S0140-6736(16)00378-0
Schwartz J. et al. Estimating Causal Effects of Local Air Pollution on Daily Deaths:
Effect of Low Levels. Environ Health Perspect; DOI:10.1289/EHP232
Zhang Y, Ji X1, Ku T, Li G, Sang N. Heavy metals bound to fine particulate matter from
northern China induce season-dependent health risks: A study based on myocardial toxicity.
Environ Pollut. 2016 Jun 21;216:380-390. doi: 10.1016/j.envpol.2016.05.072. [Epub ahead of
print]
Zhang Z, et al. Long-Term Exposure to Particulate Matter and Self-Reported
Hypertension: A Prospective Analysis in the Nurses’ Health Study. Environ Health Perspect;
DOI:10.1289/EHP163
Argacha JF, et al. Air pollution and ST-elevation myocardial infarction: A case-crossover
study of the Belgian STEMI registry 2009-2013. Int J Cardiol. 2016 Jul 30;223:300-305. doi:
10.1016/j.ijcard.2016.07.191. [Epub ahead of print]
Pope CA, Bhatnagar A, McCracken J, Abplanalp WT, Conklin DJ, O’Toole TE. Exposure
to Fine Particulate Air Pollution Is Associated with Endothelial Injury and Systemic
Inflammation. Circ Res. 2016 Oct 25. pii: CIRCRESAHA.116.309279.
Alessandrini ER, et al. Association Between Short-Term Exposure to PM2.5 and PM10
and Mortality in Susceptible Subgroups: A Multisite Case-Crossover Analysis of Individual
Effect Modifiers.Am J Epidemiol. 2016 Oct 25. [Epub ahead of print]
Macintyre HL, et al. Mortality and emergency hospitalizations associated with
atmospheric particulate matter episodes across the UK in spring 2014. Environ Int. 2016 Aug
pii: S0160-4120(16)30284-7. doi: 10.1016/j.envint.2016.07.018. [Epub ahead of print]
Chen K, et al. Acute effect of ozone exposure on daily mortality in seven cities of Jiangsu
Province, China: No clear evidence for threshold. Environ Res. 2017 Feb 20;155:235-241. doi:
10.1016/j.envres.2017.02.009. [Epub ahead of print]
Xu A, et al. Acute Effects of Particulate Air Pollution on Ischemic Heart Disease
Hospitalizations in Shanghai, China. Int J Environ Res Public Health. 2017 Feb 9;14(2). pii:
30
E168. doi: 10.3390/ijerph14020168.
Fiordelisi A, et al. The mechanisms of air pollution and particulate matter in
cardiovascular diseases. Heart Fail Rev. 2017 Mar 16. doi: 10.1007/s10741-017-9606-7.
[Epub ahead of print]
Miller MR, et al. Inhaled Nanoparticles Accumulate at Sites of Vascular Disease. ACS
Nano. 2017 Apr 26. doi: 10.1021/acsnano.6b08551. [Epub ahead of print]
Chen R, et al. Fine Particulate Air Pollution and Daily Mortality: A Nationwide Analysis
in 272 Chinese Cities. Am J Respir Crit Care Med. 2017 Mar 1. doi: 10.1164/rccm.
201609-1862OC. [Epub ahead of print]
Li G, et al. Association between fine ambient particulate matter and daily total mortality:
An analysis from 160 communities of China. Sci Total Environ. 2017 May 1;599-600:108-113.
doi: 10.1016/j.scitotenv.2017.04.010. [Epub ahead of print]
Desikan A, et al. Outdoor air pollution as a possible modifiable risk factor to reduce
mortality in post-stroke population. Neural Regen Res. 2017 Mar;12(3):351-353. doi:
10.4103/1673-5374.202917.
Bell G, et al. Association of Air Pollution Exposures With High-Density Lipoprotein
Cholesterol and Particle Number: The Multi-Ethnic Study of Atherosclerosis. Arteriosclerosis,
Thrombosis, and Vascular Biology. 2017;37:976-982
Gondalia R, et al. Genome-wide Association Study of Susceptibility to Particulate Matter-
Associated QT Prolongation. Environ Health Perspect. 2017 Jun 8;125(6):067002. doi:
10.1289/EHP347.
Zhang Y, Peng M, Yu C, Zhang L. Burden of mortality and years of life lost due to
ambient PM10 pollution in Wuhan, China. Environ Pollut. 2017 Jul 27;230:1073-1080. doi:
10.1016/j.envpol.2017.07.053. [Epub ahead of print]
Makar M, Antonelli J, Di Q, Cutler D, Schwartz J, Dominici F. Estimating the Causal
Effect of Low Levels of Fine Particulate Matter on Hospitalization. Epidemiology. 2017 Sep;
28(5):627-634. doi: 10.1097/EDE.0000000000000690.
Liu H, et al. Air Pollution and Hospitalization for Acute Myocardial Infarction in
China.Am J Cardiol. 2017 Jun 15. pii: S0002-9149(17)30954-2. doi: 10.1016/j.amjcard.
2017.06.004. [Epub ahead of print]
Guo Y, et al. Time series analysis of ambient air pollution effects on daily mortality.
Environ Sci Pollut Res Int. 2017 Jul 13. doi: 10.1007/s11356-017-9502-7. [Epub ahead of print]
Shuster-Meiseles T, et al. ROS-generating/ARE-activating capacity of metals in roadway
particulate matter deposited in urban environment. Environmental Research, 2016; 146: 252
DOI: 10.1016/j.envres.2016.01.009
Fuller CH, Feeser KR, Sarnat JA, O’Neill MS. Air pollution, cardiovascular endpoints
31
and susceptibility by stress and material resources: a systematic review of the evidence.
Environ Health. 2017 Jun 14;16(1):58. doi: 10.1186/s12940-017-0270-0. Review.
Di Q, et al. Air Pollution and Mortality in the Medicare Population. New England
Journal of Medicine, 2017; 376 (26): 2513 DOI: 10.1056/NEJMoa1702747
Yang WY, et al. Left ventricular function in relation to chronic residential air pollution in
a general population. Eur J Prev Cardiol. 2017 Jan 1:2047487317715109. doi:
10.1177/2047487317715109. [Epub ahead of print]
Chiu HF, Weng YH, Chiu YW, Yang CY. Short-Term Effects of Ozone Air Pollution on
Hospital Admissions for Myocardial Infarction: A Time-Stratified Case-Crossover Study in
Taipei. J Toxicol Environ Health A. 2017 Jun 9:1-7. doi: 10.1080/15287394.2017.1321092.
[Epub ahead of print]
Carll AP, et al. Inhaled ambient-level traffic-derived particulates decrease cardiac vagal
influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome. Part
Fibre Toxicol. 2017 May 25;14(1):16. doi: 10.1186/s12989-017-0196-2.
Zhang C, et al. Association between air pollution and cardiovascular mortality in Hefei,
China: A time-series analysis. Environ Pollut. 2017 Aug 7. pii: S0269-7491(16)32799-3. doi:
10.1016/j.envpol.2017.06.022. [Epub ahead of print]
Goodson J, et al. In utero exposure to diesel exhaust particulates is associated with an
altered cardiac transcriptional response to transverse aortic constriction and altered DNA
methylation. The FASEB Journal, 2017; fj.201700032R DOI: 10.1096/fj.201700032R
Huang C, et al. Potential Cardiovascular and Total Mortality Benefits of Air Pollution
Control in Urban China. Circulation. 2017 Sep 7. pii: CIRCULATIONAHA.116.026487. doi:
10.1161/CIRCULATIONAHA.116.026487. [Epub ahead of print.
Ebenstein A, et al. New evidence on the impact of sustained exposure to air pollution on
life expectancy from China’s Huai River Policy. Proceedings of the National Academy of
Sciences, 2017; 201616784 DOI: 10.1073/pnas.1616784114
Sørensen M, et al. Long-Term Exposure to Road Traffic Noise and Nitrogen Dioxide and
Risk of Heart Failure: A Cohort Study. Environ Health Perspect. 2017 Sep 26;125(9):097021.
doi: 10.1289/EHP1272.
Fang X, et al. Relationship between fine particulate matter, weather condition and daily
non-accidental mortality in Shanghai, China: A Bayesian approach. PLoS One. 2017 Nov
9;12(11):e0187933. doi: 10.1371/journal.pone.0187933. eCollection 2017.
Kim H, et al. Cardiovascular Effects of Long-Term Exposure to Air Pollution: A
Population-Based Study With 900 845 Person-Years of Follow-up. J Am Heart Assoc. 2017
Nov 8;6(11). pii: e007170. doi: 10.1161/JAHA.117.007170.
Holnicki P, et al. Burden of Mortality and Disease Attributable to Multiple Air Pollutants
32
in Warsaw, Poland. Int J Environ Res Public Health. 2017 Nov 8;14(11). pii: E1359. doi:
10.3390/ijerph14111359.
Abrams J, et al. Associations between Ambient Fine Particulate Oxidative Potential and
Cardiorespiratory Emergency Department Visits. OCTOBER 2017 | VOLUME 125 | ISSUE 10.
Environ Health Perspect; DOI:10.1289/EHP1545
Ward-Caviness CK, et al. Associations Between Residential Proximity to Traffic and
Vascular Disease in a Cardiac Catheterization Cohort. Arterioscler Thromb Vasc Biol. 2017
Nov 30. pii: ATVBAHA.117.310003. doi: 10.1161/ATVBAHA.117.310003. [Epub ahead of
print].
Magalhaes S, et al. Impacts of exposure to black carbon, elemental carbon, and ultrafine
particles from indoor and outdoor sources on blood pressure in adults: A review of
epidemiological evidence. Environ Res. 2017 Nov 28;161:345-353. doi: 10.1016/j.envres.
2017.11.030. [Epub ahead of print]
Cappellari M, et al. Association between short- and medium-term air pollution exposure
and risk of mortality after intravenous thrombolysis for stroke. J Thromb Thrombolysis. 2017
Nov 28. doi: 10.1007/s11239-017-1589-7. [Epub ahead of print]
Corrigan AE, et al. Fine particulate matters: The impact of air quality standards on
cardiovascular mortality. Environ Res. 2017 Nov 28;161:364-369. doi: 10.1016/j.envres.
2017.11.025. [Epub ahead of print]
Sinharay R, et al. Respiratory and cardiovascular responses to walking down a trafficpolluted
road compared with walking in a traffic-free area in participants aged 60 years and
older with chronic lung or heart disease and age-matched healthy controls: a randomised,
crosso. The Lancet, 2017; DOI:
Parker JD, et al. Particulate Matter Air Pollution Exposure and Heart Disease Mortality
Risks by Race and Ethnicity in the United States: 1997-2009 NHIS with Mortality Followup
Through 2011. Circulation. 2017 Dec 13. pii: CIRCULATIONAHA.117.029376. doi: 10.1161/
CIRCULATIONAHA.117.029376. [Epub ahead of print]
Kim SE, et al. Associations between mortality and prolonged exposure to elevated
particulate matter concentrations in East Asia. Environ Int. 2017 Oct 30. pii:
S0160-4120(17)30909-1. doi: 10.1016/j.envint.2017.10.010. [Epub ahead of print]
Chen CC, et al. Association between gaseous air pollution and hospital admissions for
hypertension in Taipei, Taiwan. J Toxicol Environ Health A. 2017 Dec 22:1-7. doi:
10.1080/15287394.2017.1395573. [Epub ahead of print]
Tibuakuu M, et al. Exposure to ambient air pollution and calcification of the mitral
annulus and aortic valve: the multi-ethnic study of atherosclerosis (MESA). Environ Health.
2017 Dec 21;16(1):133. doi: 10.1186/s12940-017-0346-x.
33
Qian D, et al. Association of Short-term Exposure to Air Pollution With Mortality in
Older Adults. JAMA. 2017;318(24):2446-2456. doi:10.1001/jama.2017.17923
Carter JD, et al. Ultrafine particulate matter exposure impairs vasorelaxant response in
superoxide dismutase 2-deficient murine aortic rings. J Toxicol Environ Health A. 2018;81(5):
106-115. doi: 10.1080/15287394.2017.1420504. Epub 2017 Dec 26.
Ji X, et al. Potential Role of Inflammation in Associations between Particulate Matter and
Heart Failure. Curr Pharm Des. 2018 Jan 10. doi: 10.2174/1381612824666180110150550.
[Epub ahead of print]
Bai L, et al. Exposure to Ambient Ultrafine Particles and Nitrogen Dioxide and Incident
Hypertension and Diabetes. Epidemiology. 2018 Jan 9. doi: 10.1097/EDE.0000000000000798.
[Epub ahead of print]
Guan T, et al. Differential Susceptibility in Ambient Particle-Related First-Ever Stroke
Onset Risk: Findings From a National Case-Crossover Study. Am J Epidemiol. 2018 Jan 17.
doi: 10.1093/aje/kwy007. [Epub ahead of print]
Buteau S, et al. Associations between ambient air pollution and daily mortality in a cohort
of congestive heart failure: Case-crossover and nested case-control analyses using a distributed
lag nonlinear model. Environ Int. 2018 Jan 17. pii: S0160-4120(17)31563-5. doi: 10.1016/
j.envint.2018.01.003. [Epub ahead of print]
Zhang Z, et al. Long-Term Exposure to Fine Particulate Matter, Blood Pressure, and
Incident Hypertension in Taiwanese Adults. Environ Health Perspect. 2018 Jan 18;126(1):
doi: 10.1289/EHP2466.
Guan L, et al. PM2.5 inhalation induces intracranial atherosclerosis which may be
ameliorated by omega 3 fatty acids. Oncotarget. 2017 Dec 16;9(3):3765-3778. doi: 10.18632/
oncotarget.23347. eCollection 2018 Jan 9.
Rasche M, et al. Rapid increases in nitrogen oxides are associated with acute myocardial
infarction: A case-crossover study. Eur J Prev Cardiol. 2018 Jan 1:2047487318755804. doi:
10.1177/2047487318755804. [Epub ahead of print]
Salameh P, et al. Hypertension prevalence and living conditions related to air pollution:
results of a national epidemiological study in Lebanon. Environ Sci Pollut Res Int. 2018 Feb
doi: 10.1007/s11356-018-1411-x. [Epub ahead of print]
Baumgartner J, et al. Household air pollution and measures of blood pressure, arterial
stiffness and central haemodynamics. Heart. 2018 Feb 9. pii: heartjnl-2017-312595. doi:
10.1136/heartjnl-2017-312595. [Epub ahead of print]
Hadley MB, et al. Developing a Clinical Approach to Air Pollution and Cardiovascular
Health.Circulation. 2018 Feb 13;137(7):725-742. doi: 10.1161/CIRCULATIONAHA.
117.030377.
34
An Z, et al. Impact of Particulate Air Pollution on Cardiovascular Health.Curr Allergy
Asthma Rep. 2018 Feb 22;18(3):15. doi: 10.1007/s11882-018-0768-8.
Erqou S, et al. Particulate Matter Air Pollution and Racial Differences in Cardiovascular
Disease Risk. Arterioscler Thromb Vasc Biol. 2018 Mar 15. pii: ATVBAHA.117.310305. doi:
10.1161/ATVBAHA.117.310305. [Epub ahead of print]
Nyhan MM, et al. Associations Between Ambient Particle Radioactivity and Blood
Pressure: The NAS (Normative Aging Study). J Am Heart Assoc. 2018 Mar 15;7(6). pii:
e008245. doi: 10.1161/JAHA.117.008245.
Kulick ER, et al. Residential Proximity to Major Roadways and Risk of Incident Ischemic
Stroke in NOMAS (The Northern Manhattan Study). Stroke. 2018 Mar 14. pii: STROKEAHA.
117.019580. doi: 10.1161/STROKEAHA.117.019580. [Epub ahead of print]
Corlin L, et al. Longitudinal associations of long-term exposure to ultrafine particles with
blood pressure and systemic inflammation in Puerto Rican adults. Environ Health. 2018 Apr
5;17(1):33. doi: 10.1186/s12940-018-0379-9.
Xie X, et al. Long-Term Effects of Ambient Particulate Matter (With an Aerodynamic
Diameter ≤2.5 μm) on Hypertension and Blood Pressure and Attributable Risk Among
Reproductive-Age Adults in China. J Am Heart Assoc. 2018 Apr 26;7(9). pii: e008553. doi:
10.1161/JAHA.118.008553.
Khan R, et al. Association between short-term exposure to fine particulate matter and
daily emergency room visits at a cardiovascular hospital in Dhaka, Bangladesh. Sci Total
Environ. 2019 Jan 1;646:1030-1036. doi: 10.1016/j.scitotenv.2018.07.288. Epub 2018 Jul 21.
Nirel R, et al. Fine and Coarse Particulate Matter Exposures and Associations with Acute
Cardiac Events among Participants in a Telemedicine Service: A Case-Crossover Study. First
Published:11 September 2018, DOI: https://doi.org/10.1289/EHP2596
Bai L, et al. Associations of Long-Term Exposure to Ultrafine Particles and Nitrogen
Dioxide with Increased Incidence of Congestive Heart Failure and Acute Myocardial Infarction.
Am J Epidemiol. 2018 Aug 28. doi: 10.1093/aje/kwy194. [Epub ahead of print]
Xie X, et al. Long-term exposure to fine particulate matter and tachycardia and heart
rate: Results from 10 million reproductive-age adults in China. Environ Pollut. 2018 Aug
11;242(Pt B):1371-1378. doi: 10.1016/j.envpol.2018.08.022. [Epub ahead of print]
Aung N, et al. Association Between Ambient Air Pollution and Cardiac Morpho-
Functional Phenotypes, insights From the UK Biobank Population Imaging Study. Originally
published3 Aug 2018Circulation. 2018;0:CIRCULATIONAHA.118.034856
Yang BY, et al. Exposure to ambient air pollution and blood lipids in adults: The 33
Communities Chinese Health Study. Environ Int. 2018 Jul 23;119:485-492. doi: 10.1016/
j.envint.2018.07.016. [Epub ahead of print]
35
Duan C, et al. Five-year exposure to PM2.5 and ozone and subclinical atherosclerosis in
late midlife women: The Study of Women’s Health Across the Nation. Int J Hyg Environ Health.
2018 Sep 17. pii: S1438-4639(18)30155-X. doi: 10.1016/j.ijheh.2018.09.001. [Epub ahead of
print]
Downward GS, et al. Long-Term Exposure to Ultrafine Particles and Incidence of
Cardiovascular and Cerebrovascular Disease in a Prospective Study of a Dutch Cohort.Environ
Health Perspect. 2018 Dec;126(12):127007. doi: 10.1289/EHP3047.
Buszman PE, et al. Impact of air pollution on hospital patients admitted with ST- and
non-ST-segment elevation myocardial infarction in heavily polluted cities within the European
Union.Cardiol J. 2018 Dec 19. doi: 10.5603/CJ.a2018.0156. [Epub ahead of print]
Sofianopoulou E, et al. Traffic exposures, air pollution and outcomes in pulmonary
arterial hypertension: A United Kingdom cohort study analysis. Eur Respir J. 2019 Mar 28. pii:
doi: 10.1183/13993003.01429-2018. [Epub ahead of print]
Geng J, et al. PM2.5 promotes plaque vulnerability at different stages of atherosclerosis
and the formation of foam cells via TLR4/MyD88/NFκB pathway. Ecotoxicol Environ Saf. 2019
Mar 25;176:76-84. doi: 10.1016/j.ecoenv.2019.03.068. [Epub ahead of print]
Malik AO, et al. Association of Long-Term Exposure to Particulate Matter and Ozone
With Health Status and Mortality in Patients After Myocardial Infarction. Circ Cardiovasc
Qual Outcomes. 2019 Apr;12(4):e005598. doi: 10.1161/CIRCOUTCOMES.119.005598.

Pollution and the Brain

The systemic inflammation caused by air pollution also affects the brain
Air pollution components, including toxic, metallic nanoparticles, reach the brain and
can penetrate deeply into the parenchyma.
Many of the compounds adsorbed to particulate matter are neurotoxic.
Air pollution causes CNS oxidative stress, neuroinflammation, neuronal damage,
neuronal loss, loss of brain mass, cortical stress measured by EEG, enhancement of Alzheimer type-abnormal filamentous proteins (beta amyloid and phosphorylated tau), BBB and microglial (immune system) changes, and cerebrovascular damage. Many of
these changes can be found in infants, children and young adults.
Air pollution exposure is associated with almost the full range of clinical neurologic disorders throughout the age spectrum, including lower intelligence, diminished motor function, attention deficit and behavioral problems, decreased cognition and accelerated
dementia in adults, delinquent behavior in adolescents, higher rates of strokes, ALS, relapses in multiple sclerosis, autism, impaired olfactory sense, Parkinson’s, and other neurodegenerative diseases, depression, anxiety, substance abuse, schizophrenia and suicide.
Acute air pollution exposure on the way to school affects students’ attention span during the ensuing school day.
Prenatal exposure to air pollution is particularly harmful to fetal brain development, even causing loss of white matter involving the left hemisphere which results in impaired cognition and behavioral disorders in childhood.

Calderon-Garciduenas L, Mora-Tiscareno A, Ontiveros E, et al. Air pollution, cognitive
deficits and brain abnormalities: a pilot study with children and dogs. Brain Cogn. 2008 Nov;
68(2):117-27. Epub 2008 Jun 11..
Calderon-Garciduenas L, Solt AC, et al. Long-term air pollution exposure is associated with
neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier,
ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in
children and young adults. Toxicol Pathol. 2008;36(2): 289-310. Epub 2008 Mar 18
Calderon-Garciduenas L, Franco-Lira M, Torres-Jardon R. Pediatric Respiratory and
Systemic Effects of Chronic Air Pollution Exposure: Nose, Lung, Heart, and Brain Pathology.
Toxicol Pathol, Vol. 35, No1, 154-162 (2007)
Hartz A, Bauer B, Block M, Diesel exhaust particles induce oxidative stress, proinflammatory
signaling, and P-glycoprotein, up-regulation at the blood-brain barrier. The FASEB Journal
2008;22:2723-2733.
37
Cruts B, van Etten L, Tornquvist H, et al. Exposure to diesel exhaust induces changes in EEG
in human volunteers. Part Fibre Toxicol. 2008;5:4. March11. dol: 1186/1743-8977-5-4.
Suglia SF, et al. Association of Black Carbon with Cognition among Children in a
Prospective Birth Cohort Study Am J Epidemiology 2008 167:280-286.
Wang, Z., Zeng, X, Zeng, Y, Wang, S. Chen, S. Association of traffic-related air pollution with
children’s neurobehavioral functions in Quanzhou, China. Environ Health Perspect. 2009 Oct;
117 (10):1612-8 Epub. 2009 May 11.
Volk H, Hertz-Picciotto I, Delwiche L , Lurmann F, McConnell R. Residential Proximity to
Freeways and Autism in the CHARGE study. Environ Health Perspect. 2010 Dec 13. [Epub
ahead of print] PMID: 21156395.
Morales, E., Julvez, J., Torrent, M., et al. Association of Early-life Exposure to Household
Gas Appliances and Indoor Nitrogen Dioxide With Cognition and Attention Behavior in
Preschoolers. American Journal of Epidemiology 2009 169(11):1327-1336;
Suzuki, T., Oshio, S., Iwata, M., et al. In utero exposure to a low concentration of diesel
exhaust affects spontaneous locomotor activity and monoaminergic system in male mice.
Particle and Fibre Toxicology 2010, 7:7doi:10.1186/1743-8977-7-7
Freire, C., Ramos, R., Puertas, R., et al. Association of traffic-related air pollution with
cognitive development in children. J Epidemiol Community Health 2010;64:223-228
Edwards SC, Jedrychowski W, Butscher M, Camann D, Kieltyka A, Mroz E, et al. 2010.
Prenatal Exposure to Airborne Polycyclic Aromatic Hydrocarbons and Children’s Intelligence
at Age 5 in a Prospective Cohort Study in Poland. Environ Health Perspect :-. doi:10.1289/ehp.
0901070
Calderón-Garcidueñas L, Reed W, Maronpot RR, Henríquez-Roldán C, Delgado- Chavez R,
Calderón-Garcidueñas A, Dragustinovis I, Franco-Lira M, Aragón-Flores M, Solt AC,
Altenburg M, Torres-Jardón R, Swenberg JA. Brain inflammation and Alzheimer’s-like
pathology in individuals exposed to severe air pollution. Toxicol Pathol. 2004 Nov-Dec;32(6):
650-8.
Calderón-Garcidueñas L, Franco-Lira M, Henríquez-Roldán C, et al., “Urban air pollution:
influences on olfactory function and pathology in exposed children and young adults,”
Experimental and Toxicologic Pathology, vol. 62, no. 1, pp. 91–102, 2010.
G. Oberdörster , Z. Sharp , V. Atudorei , A. Elder , R. Gelein , W. Kreyling and C. Cox .
Translocation of Inhaled Ultrafine Particles to the Brain. Inhalation Toxicology 2004, Vol. 16,
No. 6-7, Pages 437-445
Perera, FP, L Zhigang, R Whyatt, L Hoepner, S Wang, D Camann and V Rauh. 2009. 2009.
Prenatal airborne polycyclic aromatic hydrocarbon exposure and child IQ at age 5 years.
Pediatrics doi: 10.1542/peds.2008-3506.
38
Lopez I, Beltran-Parrazal1 L, Abhimanyu Amarnani A. Evidence for oxidative stress in the
developing cerebellum of the rat after chronic mild carbon monoxide exposure (0.0025% in air)
BMC Neuroscience 2009, 10:53doi: 10.1186/1471-2202-10-53
Zhou Z, Yuan T, Chen Y, Qu L, Rauh V, Zhang Y, Tang D, Perera F, Li T. Benefits of
Reducing Prenatal Exposure to Coal-Burning Pollutants to Children’s Neurodevelopment in
China Research Article, published 14 Jul 2008 | doi:10.1289/ ehp.11480
Thomson, E.M. et al. (2007) Air pollution alters brain and pituitary endothelin-1 and
inducible nitric oxide synthase gene expression. Environ. Res. 105, 224233
Peters, A. et al. (2006) Translocation and potential neurological effects of fine and ultrafine
particles a critical update. Part. Fibre Toxicol. 3, 13
Hong, Y.C. et al. (2002) Air pollution: a new risk factor in ischemic stroke mortality. Stroke
33, 2165–2169
Kettunen, J. et al. (2007) Associations of fine and ultrafine particulate air pollution with
stroke mortality in an area of low air pollution levels. Stroke 38, 918–922
Calderon-Garciduenas, L. et al. (2002) Air pollution and brain damage. Toxicol. Pathol. 30,
373–389
Calderon-Garciduenas, L. et al. (2003) DNA damage in nasal and brain tissues of canines
exposed to air pollutants is associated with evidence of chronic brain inflammation and
neurodegeneration. Toxicol. Pathol. 31, 524–538
Mateen F, Brook R. Air Pollution as an Emerging Global Risk Factor for Stroke JAMA
2011;305(12):1240-1241.doi:10.1001/jama.2011.352
Lopez IA, Acuna D, Beltran-Parrazal L, Lopez IE, Amarnani A, Cortes M, Edmond J.
Evidence for oxidative stress in the developing cerebellum of the rat after chronic mild carbon
monoxide exposure (0.0025% in air) BMC Neuroscience 2009, 10:53 (27 May 2009)
Morgan TE, Davis DA, Iwata N, Tanner JA, Snyder D, Ning Z, et al. 2011. Glutamatergic
Neurons in Rodent Models Respond to Nanoscale Particulate Urban Air Pollutants In Vivo and
In Vitro. Environ Health Perspect :-. doi:10.1289/ehp.1002973
Gackière F, Saliba L, Baude A, Bosler O, Strube C. Ozone inhalation activates stressresponsive
regions of the central nervous system. J Neurochem. 2011 Apr 6. doi: 10.1111/j.
1471-4159.2011.07267.x. [Epub ahead of print]
.
Calderón-Garcidueñas L, D’Angiulli A, Kulesza RJ, Torres-Jardón R, Osnaya N, Romero L,
Keefe S, Herritt L, Brooks DM, Avila-Ramirez J, Delgado-Chávez R, Medina- Cortina H,
González-González LO. Air pollution is associated with brainstem auditory nuclei pathology
and delayed brainstem auditory evoked potentials. Int J Dev Neurosci. 2011 Mar 31. [Epub
ahead of print]
39
Power MC, Weisskopf MG, Alexeeff SE, Coull BA, Spiro A III, Schwartz J 2011. Traffic-
Related Air Pollution and Cognitive Function in a Cohort of Older Men. Environ Health
Perspect 119:682-687. doi:10.1289/ehp.1002767
Fonken LK, Xu X, Weil ZM, Chen G, Sun Q, Rajagopalan S, Nelson RJ. Air pollution
impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine
expression and morphology. Molecular Psychiatry, 2011; DOI: 10.1038/mp. 2011.76
Levesque S, Surace MJ, McDonald J, Block ML. Air pollution and the brain: Subchronic
diesel exhaust exposure causes neuroinflammation and elevates early markers of
neurodegenerative disease. J Neuroinflammation. 2011 Aug 24;8(1):105. [Epub ahead of print]
Guxens M, Aguilera I, Ballester F, Estarlich M, Fernández-Somoano A, Lertxundi A,
Lertxundi N, Mendez MA, Tardón A, Vrijheid M, Sunyer J. Prenatal Exposure to Residential Air
Pollution and Infant Mental Development: Modulation by Antioxidants and Detoxification
Factors. Environ Health Perspect. 2011 Aug 25. [Epub ahead of print]
Calderón-Garcidueñas L, Kavanaugh M, Block M, D’Angiulli A, Delgado-Chávez R, Torres-
Jardón R, González-Maciel A, Reynoso-Robles R, Osnaya N, Villarreal-Calderon R, Guo R,
Hua Z, Zhu H, Perry G, Diaz P. Neuroinflammation, Alzheimer’s Disease- Associated
Pathology, and Down-Regulation of the Prion-Related Protein in Air Pollution Exposed
Children and Young Adults. J Alzheimers Dis. 2011 Sep 28. [Epub ahead of print]
Calderón-Garcidueñas L, Engle R, Mora-Tiscareño A, Styner M, Gómez-Garza G, Zhu H,
Jewells V, Torres-Jardón R, Romero L, Monroy-Acosta ME, Bryant C, González- González LO,
Medina-Cortina H, D’Angiulli A. Exposure to severe urban air pollution influences cognitive
outcomes, brain volume and systemic inflammation in clinically healthy children. Brain Cogn.
2011 Oct 25. [Epub ahead of print]
Ranft U, Schikowski T, Sugiri D, Krutmann J, Krämer U. Long-term exposure to trafficrelated
particulate matter impairs cognitive function in the elderly. Environ Res. 2009 Nov;
109(8):1004-11. Epub 2009 Sep 4.
Henn BC, Schnaas L, Ettinger AS, Schwartz J, Lamadrid-Figueroa H, Hernández- Avila M,
et al. 2011. Associations of Early Childhood Manganese and Lead Coexposure with
Neurodevelopment. Environ Health Perspect 120:126-131. http://dx.doi.org/ 10.1289/ehp.
1003300
Ciesielski T, Weuve J, Bellinger DC, Schwartz J, Lanphear B, Wright RO 2012. Cadmium
Exposure and Neurodevelopmental Outcomes in U.S. Children. Environ Health Perspect :-.
http://dx.doi.org/10.1289/ehp.1104152
Weuve J, Puett R, Schwartz J, Yanosky J, Laden F, Grodstein F. Exposure to Particulate Air
Pollution and Cognitive Decline in Older Women Arch Intern Med. 2012;172(3):219-227. doi:
10.1001/archinternmed.2011.683
40
Perera FP, Tang D, Wang S, Vishnevetsky J, Zhang B, Diaz D, Camann D, Rauh V.
Prenatal Polycyclic Aromatic Hydrocarbon (PAH) Exposure and Child Behavior at age 6-7.
Environ Health Perspect. 2012 Mar 22. [Epub ahead of print]
Calderón-Garcidueñas L, Serrano-Sierra A, Torres-Jardón R, Zhu H, Yuan Y, Smith D,
Delgado-Chávez R, Cross JV, Medina-Cortina H, Kavanaugh M, Guilarte TR. The impact of
environmental metals in young urbanites’ brains. Exp Toxicol Pathol. 2012 Mar 19. [Epub
ahead of print]
Lewis J, Bench G, Myers O, Tinner B, Staines W, Barr E, Divine KK, Barrington W,
Karlsson J (2005) Trigeminal uptake and clearance of inhaled manganese chloride in rats and
mice. Neurotoxicology 26:113–23.
Calderón-Garcidueñas L, Mora-Tiscareño A, Styner M, Zhu H, Torres-Jardón R, Carlos E,
Solorio-López E, Medina-Cortina H, Kavanaugh M, D’Angiulli A. White Matter
Hyperintensities, Systemic Inflammation, Brain Growth, and Cognitive Functions in Children
Exposed to Air Pollution. J Alzheimers Dis. 2012 Apr 18. [Epub ahead of print]
Moulton PV, Yang W. Air pollution, oxidative stress, and Alzheimer’s disease. J Environ
Public Health. 2012;2012:472751. Epub 2012 Mar 15.
Bos I, De Boever P, Emmerechts J, Buekers J, Vanoirbeek J, Meeusen R, Van Poppel M,
Nemery B, Nawrot T, Panis LI. Changed gene expression in brains of mice exposed to traffic in
a highway tunnel. Inhal Toxicol. 2012 Aug;24(10):676-86.
Boucher O, et al. Prenatal Methylmercury, Postnatal Lead Exposure, and Evidence of
Attention Deficit/Hyperactivity Disorder among Inuit Children in Arctic Québec. Environ
Health Perspect 120:0000–0000 (2012). http://dx.doi.org/10.1289/ ehp.1204976 [Online 21
September 2012]
Volk H, Lurmann F, Penfold B, Hertz-Picciotto I, McConnell R. Traffic-Related Air
Pollution, Particulate Matter, and Autism. Arch Gen Psychiatry. 2012;():1-7. doi: 10.1001/
jamapsychiatry.2013.266.
Chen R, Zhang Y, Yang C, Zhao Z, Xu X, Kan H. Acute Effect of Ambient Air Pollution on
Stroke Mortality in the China Air Pollution and Health Effects Study. Stroke. 2013 Feb 7. [Epub
ahead of print]
Allen, JL, K Conrad, G Oberdörster, CJ Johnston, B Sleezer and BA Cory-Slechta. 2013.
Developmental exposure to concentration ambient particles and preferences for immediate
reward in mice. Environmental Health Perspectives 121(1): 32-38 http:// dx.doi.org/10.1289/
ehp.1205505.
Becerra T, Wilhelm M, Olsen J, Cockburn M, Ritz B. Ambient Air Pollution and Autism in
Los Angeles County, California. Environ Health Perspect 121:380–386 (2013). http://
dx.doi.org/10.1289/ehp.1205827 [Online 18 December 2012]
41
Lucchini, RG, S Zoni, S Guazzetti, E Bontempi, S Micheletti, K Broberg, G Parrinello and
DR Smith. 2012. Inverse association of intellectual function with very low blood lead but not
with manganese exposure in Italian adolescents. Environmental Research http://dx.doi.org/
10.1016/j.envres.2012.08.003.
http://www.sciencenews.org/view/feature/id/58906/title/Destination_brain
Newman N, Ryan P, LeMasters G, Levin L, Bernstein D, Khurana-Hershey GK, Lockey JE,
Villareal M, Reponen T, Grinshpun S, Sucharew H, Dietrich KN. Traffic- Related Air Pollution
Exposure in the First Year of Life and Behavioral Scores at Seven Years of Age. Environ Health
Perspect (): .doi:10.1289/ehp.1205555
Roberts AL, et al. Perinatal Air Pollutant Exposures and Autism Spectrum Disorder in the
Children of Nurses’ Health Study II Participants. Environmental Health Perspectives, 2013
DOI: 10.1289/ehp.1206187
Chiu, YHM, DC Bellinger, BA Coull, S Anderson, R Barber, RO Wright and RJ Wright.
Associations between traffic-related black carbon exposure and attention in a prospective
birth cohort of urban children. Environmental Health Perspectives http:// ehp.niehs.nih.gov/
1205940/
Ljubimova JY, Kleinman MT, Karabalin NM, Inoue S, Konda B, Gangalum P, Markman JL,
Ljubimov AV, Black KL. Gene expression changes in rat brain after short and long exposures to
particulate matter in Los Angeles basin air: Comparison with human brain tumors. Exp Toxicol
Pathol. 2013 May 17. pii: S0940-2993(13)00054-7. doi: 10.1016/j.etp.2013.04.002. [Epub
ahead of print]
Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K,
McConnell R, Sioutas C, Finch CE, Morgan TE. Prenatal exposure to urban air nanoparticles
in mice causes altered neuronal differentiation and depression-like responses. PLoS One. 2013
May 29;8(5):e64128. doi: 10.1371/journal.pone.0064128. Print 2013.
Jung CR, Lin YT, Hwang BF. Air Pollution and Newly Diagnostic Autism Spectrum
Disorders: A Population-Based Cohort Study in Taiwan. PLoS One. 2013 Sep 25;8(9):e75510.
Davis DA, Akopian G, Walsh JP, Sioutas C, Morgan TE, Finch CE. Urban air pollutants
reduce synaptic function of CA1 neurons via an NMDA/NO· pathway in vitro. J Neurochem.
2013 Aug 8. doi: 10.1111/jnc.12395. [Epub ahead of print]
Ejaz S, Anwar K, Ashraf M. MRI and neuropathological validations of the involvement of air
pollutants in cortical selective neuronal loss. Environ Sci Pollut Res Int. 2013 Nov 15. [Epub
ahead of print]
Chiu HF, Yang CY. Short-term effects of fine particulate air pollution on ischemic stroke
occurrence: a case-crossover study. J Toxicol Environ Health A. 2013;76(21): 1188-97. doi:
10.1080/15287394.2013.842463.
42
Volk, H, Kerin T, Lurmann F, Hertz-Picciotto, I, McConnell R, Campbell D. Autism
Spectrum Disorder: Interaction of Air Pollution with the MET Receptor Tyrosine Kinase Gene’,
Epidemiology 14 November 2013 doi: 10.1097/EDE.0000000000000030
Costa L, et al. Neurotoxicants Are in the Air: Convergence of Human, Animal, and In Vitro
Studies on the Effects of Air Pollution on the Brain. BioMed Research International. Volume
2014 (2014), Article ID 736385, 8 pages http://dx.doi.org/ 10.1155/2014/736385
Genc S, Zadeoglulari Z, Fuss SH, and Genc K, “The adverse effects of air pollution on the
nervous system,” Journal of Toxicology, vol. 2012, Article ID 782462, 23 pages, 2012
Block ML, and Calderón-Garcidueñas L. “Air pollution: mechanisms of neuroinflammation
and CNS disease,” Trends in Neurosciences, vol. 32, no. 9, pp. 506– 516, 2009
Calderón-Garcidueñas L, Azzarelli B, Acuna H. “Air pollution and brain damage,”
Toxicologic Pathology, vol. 30, no. 3, pp. 373–389, 2002
Calderon-Garciduenas L, Cross JV, Franco-Lira M. “Brain immune interactions and air
pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), interleukin-6
(IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal
fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution,”
Frontiers in Neuroscience, vol. 7, article 183, 2013
Chen J-C, and Schwartz J, “Neurobehavioral effects of ambient air pollution on cognitive
performance in US adults,” NeuroToxicology, vol. 30, no. 2, pp. 231–239, 2009
Boucher O, et al. Domain-Specific Effects of Prenatal Exposure to PCBs, Mercury, and
Lead on Infant Cognition: Results from the Environmental Contaminants and Child
Development Study in Nunavik. Environ Health Perspect; DOI:10.1289/ehp.1206323
Rzhetsky A, Bagley SC, Wang K, Lyttle CS, Cook EH Jr, et al. (2014) Environmental and
State-Level Regulatory Factors Affect the Incidence of Autism and Intellectual Disability. PLoS
Comput Biol 10(3): e1003518. doi:10.1371/journal.pcbi. 1003518
Tang D, Lee J, Muirhead L, Li TY, Qu L, Yu J, Perera F. Molecular and
neurodevelopmental benefits to children of closure of a coal burning power plant in china. PLoS
One. 2014 Mar 19;9(3):e91966. doi: 10.1371/journal.pone.0091966. eCollection 2014.
Perera F, Weiland K, Neidell M, Wang S. Prenatal exposure to airborne polycyclic aromatic
hydrocarbons and IQ: Estimated benefit of pollution reduction. J Public Health Policy. 2014
May 8. doi: 10.1057/jphp.2014.14. [Epub ahead of print]
Allen J, et al. Early Postnatal Exposure to Ultrafine Particulate Matter Air Pollution:
Persistent Ventriculomegaly, Neurochemical Disruption, and Glial Activation Preferentially in
Male Mice. Environ Health Perspect; DOI:10.1289/ehp.1307984
Ailshire J, Clarke P. Fine Particulate Matter Air Pollution and Cognitive Function Among
U.S. Older Adults. Gerontol B Psychol Sci Soc Sci (2014) doi: 10.1093/geronb/ gbu064. First
43
published online: June 6, 2014
Ailshire JA, Crimmins EM. Fine Particulate Matter Air Pollution and Cognitive Function
Among Older US Adults. Am J Epidemiol. 2014 Jun 24. pii: kwu155. [Epub ahead of print]
Liu J, Liu X, Wang W, McCauley L, Pinto-Martin J, Wang Y, Li L, Yan C, Rogan WJ. 2014.
Blood lead levels and children’s behavioral and emotional problems: a cohort study. JAMA
Pediatr; doi:10.1001/jamapediatrics.2014.332.
Tonne C, Elbaz A, Beevers S, Singh-Manoux A. Traffic-related Air Pollution in Relation to
Cognitive Function in Older Adults. Epidemiology. 2014 Jul 16. [Epub ahead of print]
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen
R, Cesaroni G, Chatzi L, de Agostini M, de Nazelle A, Eeftens M, Fernandez MF, Fernández-
Somoano A, Forastiere F, Gehring U, Ghassabian A, Heude B, Jaddoe VW, Klümper C,
Kogevinas M, Krämer U, Larroque B, Lertxundi A, Lertxuni N, Murcia M, Navel V,
Nieuwenhuijsen M, Porta D, Ramos R, Roumeliotaki T, Slama R, Sørensen M, Stephanou EG,
Sugiri D, Tardón A, Tiemeier H, Tiesler CM, Verhulst FC, Vrijkotte T, Wilhelm M, Brunekreef
B, Pershagen G, Sunyer J. Air Pollution During Pregnancy and Childhood Cognitive and
Psychomotor Development: Six European Birth Cohorts. Epidemiology. 2014 Jul 16. [Epub
ahead of print]
von Ehrenstein OS, Aralis H, Cockburn M, Ritz B. In Utero Exposure to Toxic Air Pollutants
and Risk of Childhood Autism. Epidemiology. 2014 Jul 21. [Epub ahead of print]
Volk HE, Kerin T, Lurmann F, Hertz-Picciotto I, McConnell R, Campbell DB. Autism
spectrum disorder: interaction of air pollution with the MET receptor tyrosine kinase gene.
Epidemiology. 2014 Jan;25(1):44-7. doi: 10.1097/EDE.0000000000000030.
Kim E, et al. Prenatal exposure to PM10 and NO2 and children’s neurodevelopment from
birth to 24 months of age: mothers and Children’s Environmental Health (MOCEH) study. Sci
Total Environ. 2014 May 15;481:439-45. doi: 10.1016/j.scitotenv. 2014.01.107. Epub 2014 Mar
12.
Kalkbrenner AE, Windham GC, Serre ML, Akita Y, Wang X, Hoffman K, Thayer BP, Daniels
JL. Particulate Matter Exposure, Prenatal and Postnatal Windows of Susceptibility, and Autism
Spectrum Disorders. Epidemiology. 2014 Oct 3. [Epub ahead of print]
Jedrychowski WA, Perera FP, Camann D, Spengler J, Butscher M, Mroz E, Majewska R,
Flak E, Jacek R, Sowa A. Prenatal exposure to polycyclic aromatic hydrocarbons and cognitive
dysfunction in children. Environ Sci Pollut Res Int. 2014 Sep 26. [Epub ahead of print]
Calderón-Garcidueñas L, Calderón-Garcidueñas A, Torres-Jardón R, Avila-Ramírez J,
Kulesza RJ, Angiulli AD. Air pollution and your brain: what do you need to know right now.
Prim Health Care Res Dev. 2014 Sep 26:1-17. [Epub ahead of print]
Perera FP, Chang H-w, Tang D, Roen EL, Herbstman J, et al. (2014) Early-Life Exposure
44
to Polycyclic Aromatic Hydrocarbons and ADHD Behavior Problems. PLoS ONE 9(11):
e111670. doi:10.1371/journal.pone.0111670
Raz R, Roberts AL, Lyall K, Hart JE, Just AC, Laden F, Weisskopf MG. Autism Spectrum
Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested
Case-Control Analysis within the Nurses’ Health Study II Cohort. Environ Health Perspect.
2014 Dec 18. [Epub ahead of print]
Tanga D, et al. Air pollution effects on fetal and child development: A cohort comparison in
China. Environmental Pollution. Volume 185, February 2014, Pages 90– 96
Calderon-Garcidueňas L. et al. Decreases in Short Term Memory, IQ, and Altered Brain
Metabolic Ratios in Urban Apolipoprotein ε 4 Children Exposed to Air Pollution. Journal of
Alzheimer’s Disease, February 2015 DOI: 10.3233/JAD-142685
Differential effects between one week and four weeks exposure to same mass of SO2 on
synaptic plasticity in rat hippocampus. Environ Toxicol. 2014 Dec 23. doi: 10.1002/tox.22093.
[Epub ahead of print]
Malek AM, Barchowsky A, Bowser R, Heiman-Patterson T, Lacomis D, Rana S, Ada Youk,
Talbott EO. Exposure to hazardous air pollutants and the risk of amyotrophic lateral sclerosis.
Environ Pollut. 2014 Dec 23;197C:181-186. doi: 10.1016/j.envpol.2014.12.010. [Epub ahead of
print]
Guarneros M, Hudson R, López-Palacios M, Drucker-Colín R. Reference Values of
Olfactory Function for Mexico City Inhabitants. Arch Med Res. 2014 Dec 22. pii:
S0188-4409(14)00283-5. doi: 10.1016/j.arcmed.2014.12.005. [Epub ahead of print]
Sunyer J, et al. Association between Traffic-Related Air Pollution in Schools and Cognitive
Development in Primary School Children: A Prospective Cohort Study. PLOS medicine.
Published: March 3, 2015DOI: 10.1371/journal.pmed.1001792
Shah A, et al. Short term exposure to air pollution and stroke: systematic review and metaanalysis.
BMJ 2015;350:h1295
Levy RJ. Carbon Monoxide Pollution and Neurodevelopment: A Public Health Concern.
Neurotoxicology and teratology : 2015 Mar 12 pg
Peterson B, et al. Effects of Prenatal Exposure to Air Pollutants (Polycyclic Aromatic
Hydrocarbons) on the Development of Brain White Matter, Cognition, and Behavior in Later
Childhood. JAMA Psychiatry. Published online March 25, 2015. doi: 10.1001/jamapsychiatry.
2015.57
Jacobson J, et al. Relation of Prenatal Methylmercury Exposure from Environmental
Sources to Childhood IQ. Environ Health Perspect; DOI:10.1289/ehp. 1408554
Tang D, Lee J, Muirhead L, Li TY, Qu L, Yu J, et al. 2014. Molecular and
neurodevelopmental benefits to children of closure of a coal burning power plant in China.
45
PLoS One 9:e91966.
Power MC, et al. The relation between past exposure to fine particulate air pollution and
prevalent anxiety: observational cohort study. BMJ, 2015; 350 (mar23 11): h1111 DOI:
10.1136/bmj.h1111
Brauer M. Air pollution, stroke, and anxiety. BMJ, 2015; 350 (mar23 11): h1510 DOI:
10.1136/bmj.h1510
Seamen N, et al. In Utero Fine Particle Air Pollution and Placental Expression of Genes in
the Brain-Derived Neurotrophic Factor Signaling Pathway: An ENVIRONAGE Birth Cohort
Study
Environ Health Perspect; DOI:10.1289/ehp.1408549
Vert C, et al. Effect of long-term exposure to air pollution on anxiety and depression in
adults: A cross-sectional study. Int J Hyg Environ Health. 2017 Jul 3. pii:
S1438-4639(17)30297-3. doi: 10.1016/j.ijheh.2017.06.009. [Epub ahead of print]
Lertxundi A, et al. Exposure to fine particle matter, nitrogen dioxide and benzene during
pregnancy and cognitive and psychomotor developments in children at 15months of age.
Environ Int. 2015 Apr 10;80:33-40. doi: 10.1016/j.envint.2015.03.007. [Epub ahead of print]
Wilker E, et al. Long-Term Exposure to Fine Particulate Matter, Residential Proximity to
Major Roads and Measures of Brain Structure. doi: 10.1161/ STROKEAHA.114.008348.
Published online before print April 23, 2015
Evens A, et al. The impact of low-level lead toxicity on school performance among children
in the Chicago Public Schools: a population-based retrospective cohort study. Environmental
Health 2015, 14:21 doi:10.1186/s12940-015-0008-9
Vishnevetskya J, et al. Combined effects of prenatal polycyclic aromatic hydrocarbons and
material hardship on child IQ. Neurotoxicology and Teratology. doi: 10.1016/j.ntt.2015.04.002.
Available online 23 April 2015
Talbott E, et al. Fine particulate matter and the risk of autism spectrum disorder.
Environmental Research. Volume 140, July 2015, Pages 414–420
Kioumourtzoglou MA, Schwartz JD, Weisskopf MG, Melly SJ, Wang Y, Dominici F,
Zanobetti A. Long-term PM2.5 Exposure and Neurological Hospital Admissions in the
Northeastern United States. Environ Health Perspect. 2015 May 15. [Epub ahead of print]
Calderón-Garcidueñas L, et al. Air Pollution and Children: Neural and Tight Junction
Antibodies and Combustion Metals, the Role of Barrier Breakdown and Brain Immunity in
Neurodegeneration. Journal of Alzheimer’s Disease, August 2014 DOI: 10.3233/JAD-141365
Debes F, Weihe P, Grandjean P. Cognitive deficits at age 22 years associated with
prenatal exposure to methylmercury. Cortex. 2015 Jun 4. pii: S0010-9452(15)00176-8. doi:
10.1016/j.cortex.2015.05.017. [Epub ahead of print]
46
Clark-Reyna SE, et al. Residential exposure to air toxics is linked to lower grade point
averages among school children in El Paso, Texas, USA. Population and Environment. July
2015
Dickerson AS, et al. Autism spectrum disorder prevalence and proximity to industrial
facilities releasing arsenic, lead or mercury. Sci Total Environ. 2015 Jul 25;536:245-251. doi:
10.1016/j.scitotenv.2015.07.024. [Epub ahead of print]
Jacobson JL, et al. Relation of Prenatal Methylmercury Exposure from Environmental
Sources to Childhood IQ. Environ Health Perspect; DOI:10.1289/ehp. 1408554
Saenen N, et al. In Utero Fine Particle Air Pollution and Placental Expression of Genes in
the Brain-Derived Neurotrophic Factor Signaling Pathway: An ENVIRONAGE Birth Cohort
Study
Environ Health Perspect; DOI:10.1289/ehp.1408549
Oudin A, et al. Traffic-Related Air Pollution and Dementia Incidence in Northern Sweden:
A Longitudinal Study. Environ Health Perspect; DOI:10.1289/ehp.1408322
Forns J. et al. Traffic-Related Air Pollution, Noise at School, and Behavioral Problems in
Barcelona Schoolchildren: A Cross-Sectional Study. Environ Health Perspect; DOI:10.1289/
ehp.1409449
Suades-González E, Gascon M, Guxens M, Sunyer J. Air Pollution and Neuropsychological
Development: A Review of the Latest Evidence. Endocrinology. 2015 Aug 4:en20151403. [Epub
ahead of print]
Yorifuji T, Kashima S, Higa Diez M, Kado Y, Sanada S, Doi H. Prenatal Exposure to
Traffic-related Air Pollution and Child Behavioral Development Milestone Delays in Japan.
Epidemiology. 2015 Aug 5. [Epub ahead of print]
Pritchard C, Rosenorn-Lanng E. Neurological deaths of American adults (55–74) and the
over 75’s by sex compared with 20 Western countries 1989–2010: Cause for concern. Surg
Neurol Int 23-Jul-2015;6:123
Weisskopf MG, Kioumourtzoglou MA, Roberts AL. Air Pollution and Autism Spectrum
Disorders: Causal or Confounded? Curr Environ Health Rep. 2015 Sep 23. [Epub ahead of
print]
Porta D, Narduzzi S, Badaloni C, Bucci S, Cesaroni G, Colelli V, Davoli M, Sunyer J,
Zirro E, Schwartz J, Forastiere F. Air pollution and cognitive development at age seven in a
prospective Italian birth cohort. Epidemiology. 2015 Sep 30. [Epub ahead of print]
Talbott EO, et al. Air toxics and the risk of autism spectrum disorder: the results of a
population based case-control study in southwestern Pennsylvania. Environ Health. 2015 Oct
6;14:80. doi: 10.1186/s12940-015-0064-1.
Zanobetti1 A, et al. A national case-crossover analysis of the short-term effect of PM2.5
47
on hospitalizations and mortality in subjects with diabetes and neurological disorders.
Environmental Health 2014, 13:38 doi:10.1186/1476-069X-13-38
Calderón-Garcidueñas L, Chao CK, Thompson C, Rodríguez-Díaz J, Franco-Lira M, et
al. (2015) CSF Biomarkers: Low Amyloid-β1-42 and BDNF and High IFN γ Differentiate
Children Exposed to Mexico City High Air Pollution V Controls. Alzheimer’sDisease
Uncertainties. J Alzheimers Dis Parkinsonism 5:189. doi: 10.4172/2161-0460.1000189
Costa LG, et al. NEUROTOXICITY OF TRAFFIC-RELATED AIR POLLUTION.
Neurotoxicology. 2015 Nov 20. pii: S0161-813X(15)30024-3. doi: 10.1016/j.neuro.2015.11.008.
[Epub ahead of print]
Laura A,, et al. Effects of particulate matter exposure on multiple sclerosis hospital
admission in Lombardy region, Italy. Environ Res. 2015 Nov 25;145:68-73. doi: 10.1016/
j.envres.2015.11.017. [Epub ahead of print]
Cooper L, Eskenazi B, Romero C, Balmes J, Smith KR. Neurodevelopmental performance
among school age children in rural Guatemala is associated with prenatal and postnatal
exposure to carbon monoxide, a marker for exposure to woodsmoke. Neurotoxicology. 2012
Mar;33(2):246-54. doi: 10.1016/j.neuro.2011.09.004. Epub 2011 Sep 24.
Allen JL, et al. Developmental Neurotoxicity of Inhaled Ambient Ultrafine Particle Air
Pollution: Parallels with Neuropathological and Behavioral Features of Autism and Other
Neurodevelopmental Disorders. Neurotoxicology. 2015 Dec 22. pii: S0161-813X(15)30048-6.
doi: 10.1016/j.neuro.2015.12.014. [Epub ahead of print]
Calderón-Garcidueñas L, et al. Air pollution, a rising environmental risk factor for
cognition, neuroinflammation and neurodegeneration: The clinical impact on children and
beyond. Rev Neurol (Paris). 2015 Dec 21. pii: S0035-3787(15)00923-6. doi: 10.1016/j.neurol.
2015.10.008. [Epub ahead of print]
Marquesa R, et al. Neurodevelopment of Amazonian children exposed to methylmercury
(from Thimerosal in vaccines) and methylmercury (from fish). Environmental Research
Available online 7 January 2016
Chen JC, et al. Ambient Air Pollution and Neurotoxicity on Brain Structure: Evidence
From Women’s Health Initiative Memory Study. ANN NEUROL 2015;78:466–476
Best EA, Juarez-Colunga E, James K, LeBlanc WG, Serdar B. Biomarkers of Exposure to
Polycyclic Aromatic Hydrocarbons and Cognitive Function among Elderly in the United States
(National Health and Nutrition Examination Survey: 2001-2002). PLoS One. 2016 Feb
5;11(2):e0147632. doi: 10.1371/journal.pone.0147632.
Mumaw CL, et al. Microglial priming through the lung-brain axis: the role of air
pollution-induced circulating factors. FASEB J. 2016 Feb 10. pii: fj.201500047. [Epub ahead
of print]
48
Jung CR, Lin YT, Hwang BF. Ozone, particulate matter, and newly diagnosed Alzheimer’s
disease: a population-based cohort study in Taiwan. J Alzheimers Dis. 2015;44(2):573-84. doi:
10.3233/JAD-140855.
Oudin, A, et al. Traffic-Related Air Pollution and Dementia Incidence in Northern
Sweden: A Longitudinal Study. Environ Health Perspect; DOI:10.1289/ehp.1408322
Margolis AE, et al. Longitudinal effects of prenatal exposure to air pollutants on selfregulatory
capacities and social competence. J Child Psychol Psychiatry. 2016 Mar 17. doi:
10.1111/jcpp.12548. [Epub ahead of print]
Clark-Reyna SE, et al. Residential exposure to air toxics is linked to lower grade point
averages among school children in El Paso, Texas, USA. Popul Environ. 2016 Mar;37(3):
319-340. Epub 2015 Jul 17.
Kim KN, et al. Long-Term Fine Particulate Matter Exposure and Major Depressive
Disorder in a Community-Based Urban Cohort. Environ Health Perspect. 2016 Apr 29. [Epub
ahead of print]
Basagaña X, et al. Neurodevelopmental Deceleration by Urban Fine Particles from
Different Emission Sources: A Longitudinal Observational Study. Environ Health Perspect.
2016 Apr 29;124(5). [Epub ahead of print]
Huang F, et al. Particulate Matter and Hospital Admissions for Stroke in Beijing, China:
Modification Effects by Ambient Temperature. J Am Heart Assoc. 2016 Jul 13;5(7). pii:
e003437. doi: 10.1161/JAHA.116.003437.
Han M, et al. Association between hemorrhagic stroke occurrence and meteorological
factors and pollutants. BMC Neurol. 2016 May 4;16(1):59. doi: 10.1186/s12883-016-0579-2.
Ajmani GS, et al. Effects of Ambient Air Pollution Exposure on Olfaction: A
Review.Environ Health Perspect. 2016 Jun 10. [Epub ahead of print]
Zhang C, et al. Role of astrocyte activation in fine particulate matter-enhancement of
existing ischemic stroke in Sprague-Dawley male rats. J Toxicol Environ Health A.
2016;79(9-10):393-401. doi: 10.1080/15287394.2016.1176615.
Colicino E, et al. Telomere Length, Long-Term Black Carbon Exposure, and Cognitive
Function in a Cohort of Older Men: The VA Normative Aging Study. Environ Health Perspect.
2016 Jun 3. [Epub ahead of print]
Oudin, A., Bråbäck, L., Oudin Åström, D., Strömgren, M., Forsberg, B.: Association
between neighbourhood air pollution concentrations and dispensed medication for psychiatric
disorders in a large longitudinal cohort of Swedish children and adolescents. BMJ Open
2016;6:e010004 doi:10.1136/bmjopen-2015-010004
Maher, B, et al. Magnetite pollution nanoparticles in the human brain. PNAS 2016 ;
published ahead of print September 6, 2016, doi:10.1073/pnas.1605941113
49
Tzivian L, et al. Long-Term Air Pollution and Traffic Noise Exposures and Mild
Cognitive Impairment in Older Adults: A Cross-Sectional Analysis of the Heinz Nixdorf Recall
Study. Environ Health Perspect; DOI:10.1289/ehp.1509824
Flores-Pajot MC, Ofner M, Do MT, Lavigne E, Villeneuve PJ. Childhood autism spectrum
disorders and exposure to nitrogen dioxide, and particulate matter air pollution: A review and
meta-analysis. Environ Res. 2016 Aug 25. pii: S0013-9351(16)30317-6. doi: 10.1016/j.envres.
2016.07.030. [Epub ahead of print]
Basagaña X, et al. Neurodevelopmental Deceleration by Urban Fine Particles from
Different Emission Sources: A Longitudinal Observational Study. Environ Health Perspect;
DOI:10.1289/EHP209
Cheng H, et al. Nanoscale Particulate Matter from Urban Traffic Rapidly Induces
Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain.
Environ Health Perspect; DOI:10.1289/EHP134
Lam J, Sutton P, Kalkbrenner A, Windham G, Halladay A, Koustas E, Lawler C, Davidson
L, Daniels N, Newschaffer C, Woodruff T. A Systematic Review and Meta-Analysis of Multiple
Airborne Pollutants and Autism Spectrum Disorder. PLoS One. 2016 Sep 21;11(9):e0161851.
doi: 10.1371/journal.pone.0161851.
Brockmeyer S, D’Angiulli A. How air pollution alters brain development: the role of
neuroinflammation. Transl Neurosci. 2016 Mar 21;7(1):24-30. doi: 10.1515/tnsci-2016-0005.
eCollection 2016.
Chen H, et al. Living near major roads and the incidence of dementia, Parkinson’s
disease, and multiple sclerosis: a population-based cohort study. Lancet. 2017 Feb
18;389(10070):718-726. doi: 10.1016/S0140-6736(16)32399-6. Epub 2017 Jan 5.
Cacciottolo M, et al. Particulate air pollutants, APOE alleles and their contributions to
cognitive impairment in older women and to amyloidogenesis in experimental models.
Translational Psychiatry (2017) 7, e1022; doi:10.1038/tp.2016.280 Published online 31
January 2017
Stingone JA, McVeigh KH, Claudio L. Early-life exposure to air pollution and greater use
of academic support services in childhood: a population-based cohort study of urban children.
Environ Health. 2017 Jan 18;16(1):2. doi: 10.1186/s12940-017-0210-z.
Pun VC, et al. Association of Ambient Air Pollution with Depressive and Anxiety
Symptoms in Older Adults: Results from the NSHAP Study. Environ Health Perspect; DOI:
10.1289/EHP494
Lee H, Myung W, Kim DK, Kim SE, Kim CT, Kim H. Short-term air pollution exposure
aggravates Parkinson’s disease in a population-based cohort. Sci Rep. 2017 Mar 16;7:44741.
doi: 10.1038/srep44741.
50
Kim D, et al. The joint effect of air pollution exposure and copy number variation on risk
for autism. Autism Res. 2017 Apr 27. doi: 10.1002/aur.1799. [Epub ahead of print]
Jayaraj RL, et al. Outdoor Ambient Air Pollution and Neurodegenerative Diseases: the
Neuroinflammation Hypothesis. Curr Environ Health Rep. 2017 Apr 25. doi: 10.1007/
s40572-017-0142-3. [Epub ahead of print]
de Water E, Proal E, Wang V, Meina SM, Schnaas L, Téllez-Rojo MM, Wright RO, Tang
CY, Horton MK. Prenatal Manganese Exposure and Intrinsic Functional Connectivity of
Emotional Brain Areas in Children. Neurotoxicology. 2017 Jun 10. pii: S0161-813X(17)30102-
X. doi: 10.1016/j.neuro.2017.06.006. [Epub ahead of print]
Dokyoon Kim D. et al. The joint effect of air pollution exposure and copy number
variation on risk for autism. Autism Research, 2017; DOI: 10.1002/aur.1799
González-Maciel A, Reynoso-Robles R, Torres-Jardón R, Mukherjee PS, Calderón-
Garcidueñas L. Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles
in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer’s Disease Development. J
Alzheimers Dis. 2017 Jun 3. doi: 10.3233/JAD-170012. [Epub ahead of print]
Lin H, et al. Exposure to air pollution and tobacco smoking and their combined effects on
depression in six low- and middle-income countries. Br J Psychiatry. 2017 Aug 10. pii: bjp.bp.
117.202325. doi: 10.1192/bjp.bp.117.202325. [Epub ahead of print]
Forns J, et al. Longitudinal association between air pollution exposure at school and
cognitive development in school children over a period of 3.5 years. Environ Res. 2017 Aug
28;159:416-421. doi: 10.1016/j.envres.2017.08.031. [Epub ahead of print]
Hullmann M, et al. Diesel engine exhaust accelerates plaque formation in a mouse model
of Alzheimer’s disease. Part Fibre Toxicol. 2017 Aug 30;14(1):35. doi: 10.1186/
s12989-017-0213-5.
Chen H, et al. Exposure to ambient air pollution and the incidence of dementia: A
population-based cohort study. Environment International. Volume 108, November 2017,
Pages 271-277
van der Kooi A, et al. Long-Term Air Pollution Exposure and Amyotrophic Lateral
Sclerosis in Netherlands: A Population-based Case–control Study. Environ Health Perspect;
DOI:10.1289/EHP1115
Alvarez-Pedrerol M, et al. Impact of commuting exposure to traffic-related air pollution
on cognitive development in children walking to school. Environmental Pollution, 2017; 231:
837 DOI: 10.1016/j.envpol.2017.08.075
Raz R, et al. Traffic Related Air Pollution and Autism Spectrum Disorder: A Population
Based Nested Case-Control Study in Israel. Am J Epidemiol. 2017 Aug 17. doi: 10.1093/aje/
kwx294. [Epub ahead of print]
51
Guo P, et al. Ambient Air Pollution and Risk for Ischemic Stroke: A Short-Term Exposure
Assessment in South China. Int J Environ Res Public Health. 2017 Sep 20;14(9). pii: E1091.
doi: 10.3390/ijerph14091091.
Younan D, et al. Longitudinal Analysis of Particulate Air Pollutants and Adolescent
Delinquent Behavior in Southern California. Journal of Abnormal Child Psychology, 2017;
DOI: 10.1007/s10802-017-0367-5
Sunyer J, et al. Traffic-related Air Pollution and Attention in Primary School Children:
Short-term Association. Epidemiology: March 2017 – Volume 28 – Issue 2 – p 181–189. doi:
10.1097/EDE.0000000000000603
Li K, et al. Early postnatal exposure to airborne fine particulate matter induces autismlike
phenotypes in male rats. Toxicol Sci. 2017 Nov 7. doi: 10.1093/toxsci/kfx240. [Epub ahead
of print]
Hanamsagar R, et al. Environment matters: microglia function and dysfunction in a
changing world. Curr Opin Neurobiol. 2017 Oct 30;47:146-155. doi: 10.1016/j.conb.
2017.10.007. [Epub ahead of print]
Sass V. et al. The effects of air pollution on individual psychological distress. Health &
Place, 2017; 48: 72 DOI: 10.1016/j.healthplace.2017.09.006
Lett LA, et al. The Combined Influence of Air Pollution and Home Learning Environment
on Early Cognitive Skills in Children. Int J Environ Res Public Health. 2017 Oct 26;14(11). pii:
E1295. doi: 10.3390/ijerph14111295.
Suwannasual U, et al. Exposure to traffic-generated air pollutants mediates alterations in
brain microvascular integrity in wildtype mice on a high-fat diet. Environ Res. 2017 Oct
23;160:449-461. doi: 10.1016/j.envres.2017.10.029. [Epub ahead of print]
Goodrich AJ, et al. Joint effects of prenatal air pollutant exposure and maternal folic acid
supplementation on risk of autism spectrum disorder. Autism Res. 2017 Nov 9. doi: 10.1002/
aur.1885. [Epub ahead of print]
Casas L, et al. Does air pollution trigger suicide? A case-crossover analysis of suicide
deaths over the life span. European Journal of Epidemiology. November 2017, Volume 32,
Issue 11, pp 973–981
Oudin A, et al. The association between daily concentrations of air pollution and visits to
a psychiatric emergency unit: a case-crossover study.Environ Health. 2018 Jan 10;17(1):4. doi:
10.1186/s12940-017-0348-8.
Jia Z, et al. Exposure to Ambient Air Particles Increases the Risk of Mental Disorder:
Findings from a Natural Experiment in Beijing. Int J Environ Res Public Health. 2018 Jan
19;15(1). pii: E160. doi: 10.3390/ijerph15010160.
Kern JK, et al. Developmental neurotoxicants and the vulnerable male brain: a systematic
52
review of suspected neurotoxicants that disproportionally affect males. Acta Neurobiol Exp
(Wars). 2017;77(4):269-296.
Calderón-Garcidueñas L, et al. Hallmarks of Alzheimer disease are evolving relentlessly
in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher
suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of age. Environmental
Research, 2018; 164: 475 DOI: 10.1016/j.envres.2018.03.023
Kalkbrenner A, et al. Air Toxics in Relation to Autism Diagnosis, Phenotype, and
Severity in a U.S. Family-Based Study. Environ Health Perspect; DOI:10.1289/EHP1867
Friedrich MJ, et al. Air Pollutants Undermine Infant Brain Development.JAMA. 2018 Feb
20;319(7):648. doi: 10.1001/jama.2018.0966.
Power MC, et al. The Association of Long-Term Exposure to Particulate Matter Air
Pollution with Brain MRI Findings: The ARIC Study. Environ Health Perspect. 2018 Feb
16;126(2):027009. doi: 10.1289/EHP2152.
Lu J, et al. Polluted Morality: Air Pollution Predicts Criminal Activity and Unethical
Behavior. Psychological Science, 2018; 095679761773580 DOI: 10.1177/0956797617735807
Jeanjean M, Bind MA, Roux J, Ongagna JC, de Sèze J, Bard D, Leray E. Ozone,
NO₂ and PM₁₀ are associated with the occurrence of multiple
sclerosis relapses. Evidence from seasonal multi-pollutant analyses. Environ Res. 2018 Feb
6;163:43-52. doi: 10.1016/j.envres.2018.01.040. [Epub ahead of print] PMID: 29426027
[PubMed – as supplied by publisher]
Wang P, et al. (2017) Socioeconomic disparities and sexual dimorphism in neurotoxic
effects of ambient fine particles on youth IQ: A longitudinal analysis. PLoS ONE 12(12):
e0188731. https://doi.org/10.1371/journal.pone.0188731
Hüls A, et al. The role of air pollution and lung function in cognitive impairment. Eur
Respir J. 2018 Feb 21;51(2). pii: 1701963. doi: 10.1183/13993003.01963-2017. Print 2018
Feb.
Gonzalez-Casanova I, et al. Prenatal exposure to environmental pollutants and child
development trajectories through 7 years. Int J Hyg Environ Health. 2018 Apr 22. pii:
S1438-4639(17)30761-7. doi: 10.1016/j.ijheh.2018.04.004. [Epub ahead of print]
Duan J, et al. Is the serious ambient air pollution associated with increased admissions
for schizophrenia? Sci Total Environ. 2018 Jul 2;644:14-19. doi: 10.1016/j.scitotenv.
2018.06.218. [Epub ahead of print]
Szyszkowicz M, et al. Ambient air pollution exposure and emergency department visits for
substance abuse. PLoS One. 2018 Jun 29;13(6):e0199826. doi: 10.1371/journal.pone.0199826.
eCollection 2018.
Buoli M, et al. Is there a link between air pollution and mental disorders? Environ Int.
53
2018 Jun 4;118:154-168. doi: 10.1016/j.envint.2018.05.044. [Epub ahead of print]
Gonzalez-Casanova I, et al. Prenatal exposure to environmental pollutants and child
development trajectories through 7 years. Int J Hyg Environ Health. 2018 Apr 22. pii:
S1438-4639(17)30761-7. doi: 10.1016/j.ijheh.2018.04.004. [Epub ahead of print]
Béjot Y, et al. A review of epidemiological research on stroke and dementia and exposure
to air pollution. Int J Stroke. 2018 Jan 1:1747493018772800. doi:
10.1177/1747493018772800. [Epub ahead of print]
Povedano M, et al. Spatial Assessment of the Association between Long-Term Exposure to
Environmental Factors and the Occurrence of Amyotrophic Lateral Sclerosis in Catalonia,
Spain: A Population-Based Nested Case-Control Study. Neuroepidemiology. 2018 May
31;51(1-2):33-49. doi: 10.1159/000489664. [Epub ahead of print]
Liu W, et al. Air pollution associated with non-suicidal self-injury in Chinese adolescent
students: A cross-sectional study. Chemosphere. 2018 Oct;209:944-949. doi: 10.1016/
j.chemosphere.2018.06.168. Epub 2018 Jun 28.
Peng C, et al. Residential Proximity to Major Roadways at Birth, DNA Methylation at
Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts,
USA) Published: 18 September 2018, DOI: https://doi.org/10.1289/EHP2034
Yolton K, et al. lifetime exposure to traffic-related air pollution and symptoms of
depression and anxiety at age 12 years. Environ Res. 2019 Mar 2;173:199-206. doi: 10.1016/
j.envres.2019.03.005. [Epub ahead of print]
Ehsanifar M, et al. Prenatal exposure to diesel exhaust particles causes anxiety, spatial
memory disorders with alters expression of hippocampal pro-inflammatory cytokines and
NMDA receptor subunits in adult male mice offspring. Ecotoxicol Environ Saf. 2019 Mar
25;176:34-41. doi: 10.1016/j.ecoenv.2019.03.090. [Epub ahead of print]
Pelch KE, et al. Environmental Chemicals and Autism: A Scoping Review of the Human
and Animal Research. Environ Health Perspect. 2019 Apr;127(4):46001. doi: 10.1289/
EHP4386.

Pollution and Chromosomal Function/Fetal Development/Fertility

Babies are essentially born pre-polluted by the air breathed by the mother during pregnancy. Particulate matter and the chemicals attached to them can cross the placenta and interfere with fetal development
Pregnant women exposed to more air pollution give birth to babies with significantly
more chromosomal aberrations including shorter telomeres and epigenetic changes which
can be passed on to multiple subsequent generations.
Exposure even to brief episodes of pollution at critical stages in the development of the
human embryo can cause a person to experience an increased likelihood of multiple
chronic diseases including those of the heart, lungs, immune system and brain and even
obesity, diabetes, cancer and shortened life expectancy.
Air pollution breathed by a pregnant mother causes epigenetic changes in the womb,
which is associated with higher rates of lung and heart disease in animals and humans in
childhood as an adult.
Pollution impairs virtually every component of human reproduction—causing sperm
DNA damage, increase in the rates of male infertility, impaired menstruation,
miscarriages and other adverse reproductive outcomes.
Children living near petrochemical industries are exposed to high PAH levels,
contributing to DNA damage. Industrial pollution is even more genotoxic than traffic
pollution.
*Regarding birth weights and poor neurologic outcomes, males are generally more
affected by prenatal air pollution than females.
*Even preconception pollution exposure of the mother increases the risk of congenital
malformations

Bruner-Tran, KL and KG Osteen. 2010. Developmental exposure to TCDD reduces fertility
and negatively affects pregnancy outcomes across multiple generations. Reproductive
Toxicology http://dx.doi.org/10.1016/j.reprotox.2010.10.003
55
Rodríguez-Trigo G, Zock J-P, Pozo-Rodríguez F, Gómez, F, et al. Health Effects in
Fishermen 2 Years After Assisting With Oil Spill Clean-up Ann Intern Med October 19, 2010
153:I-28; published ahead of print August 23, 2010.
Perera F, Tang W, Herbstman J. Relation of DNA Methylation of 5-CpG Island of ACSL3 to
Transplacental Exposure to Airborne PAH and Childhood Asthma.. PloS ONE. Feb. 16, 2009.
Hansen C, Barnett A, Prichard G. The Effect of Ambient Air Pollution during Early
Pregnancy on Fetal Ultrasound Measurements during Mid-Pregnancy. Environ Health Persp
Vol. 116, Number 3, March 2008.
Bocskay K, Tang D, Orjuela M, et al. Chromosomal Aberrations in Cord Blood Are
Associated with Prenatal Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons. Cancer
Epidem Biomarkers and Prev. Vol. 14, 506-511, Feb 2005
Perera F, Tang D, Tu Y, Biomarkers in Maternal and Newborn Blood Indicate Heightened
Fetal Susceptibility to Procarcinogenic DNA Damage. Environ Health Persp Vol 112 Number
10 July 2004
Pilsner JR, Hu H, Ettinger A, Sanchez BN, et al. Influence of prenatal lead exposure on
genomic methaylation of cord blood DNA. Environ Health Persp, April 2009
Baccarelli A. Breathe deeply into your genes!: genetic variants and air pollution effects.., Am
J Respir Crit Care Med. 2009 Mar 15;179(6):431-2.
Baccarelli A, Wright RO, Bollati V, Tarantini L, Litonjua AA, Suh HH, Zanobetti A, Sparrow
D, Vokonas PS, Schwartz J. Rapid DNA methylation changes after exposure to traffic particles.
Am J Respir Crit Care Med. 2009 Apr 1;179(7):523-4.
Huang YC, Schmitt M, Yang Z, Que LG, Stewart JC, Frampton MW, Devlin RB. Gene
expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.
Inhal Toxicol. 2010 May 27. [Epub ahead of print]
Jedrychowski WA, Perera FP, Maugeri U, Mroz E, Klimaszewska-Rembiasz M, Flak E,
Edwards S, Spengler JD. Effect of prenatal exposure to fine particulate matter on ventilatory
lung function of preschool children of non-smoking mothers. Paediatr Perinat Epidemiol. 2010
Sep;24(5):492-501.
Thomson E, Kumarathasn P, Calderon-garcidueas L, Vincent R. Air pollution alters brain
and pituitary endothelin-1 and inducible nitric oxide synthase gene expressions Environmental
Research 2007, vol. 105, no2, pp. 224-233 [10 page(s) (article)] (1 p. 1/2)
Pedersen M, Wichmann J, Autrup H, Dang DA, Decordier I, Hvidberg M, Bossi R, Jakobsen
J, Loft S, Knudsen LE. Increased micronuclei and bulky DNA adducts in cord blood after
maternal exposures to traffic-related air pollution. Environ Res. 2009 Nov; 109(8):1012-20.
Epub 2009 Sep 23.
Herr CE, Dostal M, Ghosh R, Ashwood P, Lipsett M, Pinkerton KE, Sram R, Hertz56
Picciotto I. Air pollution exposure during critical time periods in gestation and alterations in
cord blood lymphocyte distribution: a cohort of livebirths. Environ Health. 2010 Aug 2;9(1):46.
Gonzalez-Pina, R. et al. (2008) Prenatal exposure to ozone disrupts cerebellar monoamine
contents in newborn rats. Neurochem. Res. 33, 912–918
Hoxha M, Dioni L, Bonzini M, et al. Association between leukocyte telomere shortening and
exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office
workers. Environ Health. 2009; 8: 41. Published online 2009 September 21. doi:
10.1186/1476-069X-8-41
Perera FP 2008. Children Are Likely to Suffer Most from Our Fossil Fuel Addiction.
Environ Health Perspect 116:987-990. doi:10.1289/ehp.11173
Rubesa J, Rybara R, Prinosilovaa P, Veznika Z, et al. Genetic polymorphisms influence the
susceptibility of men to sperm DNA damage associated with exposure to air pollution. Mutation
Research 683 (2010) 9–15.
Rubes J, Selevan S, Evenson D, Zudova D, Vozdova M, Zudova Z, Robbins W, Perreault S.
Episodic air pollution is associated with increased DNA fragmentation in human sperm without
other changes in semen quality. Human Reproduction Vol.20, No.10 pp. 2776–2783, 2005 doi:
10.1093/humrep/dei122. Advance Access publication June 24, 2005.
Zhong Y, Carmella S, Upadhyaya P, Hochalter JB, etal. Immediate Consequences of
Cigarette Smoking: Rapid Formation of Polycyclic Aromatic Hydrocarbon Diol Epoxides
Chem. Res. Toxicol., Article ASAP DOI: 10.1021/tx100345x Publication Date (Web): December
27, 2010
Topinka J, Rossner P Jr, Milcova A, Schmuczerova J, Svecova V, Sram RJ. DNA Adducts
and Oxidative DNA Damage Induced by Organic Extracts From PM2.5 in an Acellular Assay.
Toxicol Lett. 2011 Feb 14. [Epub ahead of print]
(Industrial PM2.5 is more genotoxic and causative of oxidative stress than traffic PM2.5)
Madrigano J, Baccarelli A, Mittleman MA, Wright RO, Sparrow D, Vokonas PS, Tarantini
L, and Schwartz J. Prolonged exposure to particulate pollution, genes associated with
glutathione pathways, and DNA methylation in a cohort of older men. Environmental Health
Perspectives http://dx.doi.org/10.1289/ehp.1002773.
Oh SM, Park YR, Kim HR, Park YJ, Kim MJ, Son BH, Lee MJ, Lee SY, Chung KH. Organic
extracts of urban air pollution particulate matter (PM2.5)-induced genotoxicity and oxidative
stress in human lung bronchial epithelial cells (BEAS-2B cells). Mutat Res. 2011 Apr 16. [Epub
ahead of print]
Han X, Zhou N, Cui Z, Ma M, Li L, Cai M, et al. 2011. Association between Urinary
Polycyclic Aromatic Hydrocarbon Metabolites and Sperm DNA Damage: A Population Study in
Chongqing, China. Environ Health Perspect 119:652-657. doi:10.1289/ehp. 1002340
57
Gualtieri M, Ovrevik J, Mollerup S, Asare N, Longhin E, Dahlman HJ, Camatini M, Holme
JA. Airborne urban particles (Milan winter-PM2.5) cause mitotic arrest and cell death: Effects
on DNA, mitochondria, AhR binding and spindle organization. Mutat Res. 2011 May 30. [Epub
ahead of print]
Oya E, Ovrevik J, Arlt VM, Nagy E, Phillips DH, Holme JA. DNA damage and DNA damage
response in human bronchial epithelial BEAS-2B cells following exposure to 2-
nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis. Mutagenesis. 2011 Jun 29.
[Epub ahead of print]
Abbas I, Garçon G, Saint-Georges F, Andre V, Gosset P, Billet S, Goff JL, Verdin A, Mulliez
P, Sichel F, Shirali P. Polycyclic aromatic hydrocarbons within airborne particulate matter
(PM(2.5) ) produced DNA bulky stable adducts in a human lung cell coculture model. J Appl
Toxicol. 2011 Sep 13. doi: 10.1002/jat.1722. [Epub ahead of print]
Zhang A, Hu H, Sánchez BN, Ettinger AS, Park SK, Cantonwine D, et al. 2011. Association
between Prenatal Lead Exposure and Blood Pressure in Female Offspring. Environ Health
Perspect :-. http://dx.doi.org/10.1289/ehp.1103736
Sánchez-Guerra M, Pelallo-Martínez N, Díaz-Barriga F, Rothenberg SJ, Hernández-
Cadena L, Faugeron S, Oropeza-Hernández LF, Guaderrama-Díaz M, Quintanilla-Vega B.
Environmental polycyclic aromatic hydrocarbon (PAH) exposure and DNA damage in Mexican
children. Mutat Res. 2011 Dec 17. [Epub ahead of print]
Bind MA, Baccarelli A, Zanobetti A, Tarantini L, Suh H, Vokonas P, Schwartz J. Air
Pollution and Markers of Coagulation, Inflammation, and Endothelial Function: Associations
and Epigene-environment Interactions in an Elderly Cohort. Epidemiology. 2012 Jan 10. [Epub
ahead of print]
Reddy P, Naidoo RN, Robins TG, Mentz G, Li H, London SJ, Batterman S. GSTM1 and
GSTP1 gene variants and the effect of air pollutants on lung function measures in South African
children. Am J Ind Med. 2012 Jan 6. doi: 10.1002/ajim.22012. [Epub ahead of print]
Møller P, Folkmann JK, Danielsen PH, Jantzen K, Loft S. Oxidative Stress Generated
Damage to DNA by Gastrointestinal Exposure to Insoluble Particles. Curr Mol Med. 2012 Jan
[Epub ahead of print]
van den Hooven EH, de Kluizenaar Y, Pierik FH, Hofman A, van Ratingen SW, Zandveld
PY, et al. 2012. Chronic Air Pollution Exposure during Pregnancy and Maternal and Fetal Creactive
Protein Levels. The Generation R Study. Environ Health Perspect :-. http://dx.doi.org/
10.1289/ehp.1104345
Manikkam M, Guerrero-Bosagna C, Tracey R, Haque MM, Skinner MK (2012)
Transgenerational Actions of Environmental Compounds on Reproductive Disease and
Identification of Epigenetic Biomarkers of Ancestral Exposures. PLoS ONE 7(2): e31901. doi:
58
10.1371/journal.pone.0031901
Herbstman JB, Tang D, Zhu D, Qu L, Sjödin A, Li Z, et al. 2012. Prenatal Exposure to
Polycyclic Aromatic Hydrocarbons, Benzo[a]pyrene–DNA Adducts, and Genomic DNA
Methylation in Cord Blood. Environ Health Perspect 120:733-738. http://dx.doi.org/ 10.1289/
ehp.1104056
Janssen BG, Munters E, Pieters N, Smeets K, Cox B, Cuypers A, et al. 2012. Placental
Mitochondrial DNA Content and Particulate Air Pollution During in Utero Life. Environ Health
Perspect :-. http://dx.doi.org/10.1289/ehp.1104458
Huang HB, Lai CH, Chen GW, Lin YY, Jaakkola JJ, Liou SH, Wang SL. Traffic- related air
pollution and DNA damage: a longitudinal study in taiwanese traffic conductors. PLoS One.
2012;7(5):e37412. Epub 2012 May 21.
Orjuela M, Liu X, et al. Urinary napthol metabolites and chromosomal aberrations in 5 yr
old children. Cancer Epidemiol Biomarkers Prev, May 9, 2012 DOI:
10.1158/1055-9965.EPI-12-0214
Fustinoni S, Rossella F, Polledri E, Bollati V, Campo L, Byun HM, Agnello L, Consonni D,
Pesatori AC, Baccarelli A, Bertazzi PA. Global DNA methylation and low- level exposure to
benzene. Med Lav. 2012 Mar-Apr;103(2):84-95.
Madrigano J, Baccarelli A, Mittleman MA, Sparrow D, Spiro A 3rd, Vokonas PS, Cantone
L, Kubzansky L, Schwartz J. Air Pollution and DNA Methylation: Interaction by Psychological
Factors in the VA Normative Aging Study. Am J Epidemiol. 2012 Jul 12. [Epub ahead of print]
Hou L, Wang S, Dou C, Zhang X, Yu Y, Zheng Y, Avula U, Hoxha M, Díaz A, McCracken J,
Barretta F, Marinelli B, Bertazzi PA, Schwartz J, Baccarelli AA. Air pollution exposure and
telomere length in highly exposed subjects in Beijing, China: A repeated-measure study.
Environ Int. 2012 Aug 4;48C:71-77. [Epub ahead of print]
Tillett T Potential Mechanism for PM10 Effects on Birth Outcomes: In Utero Exposure
Linked to Mitochondrial DNA Damage. Environ Health Perspect 120:a363- a363. http://
dx.doi.org/10.1289/ehp.120-a363b
Jedrychowski WA, Perera FP, Spengler JD, Mroz E, Stigter L, Flak E, Majewska R,
Klimaszewska-Rembiasz M, Jacek R. Intrauterine exposure to fine particulate matter as a risk
factor for increased susceptibility to acute broncho-pulmonary infections in early childhood. Int
J Hyg Environ Health. 2013 Jan 16. pii: S1438-4639(12)00150-2. doi: 10.1016/j.ijheh.
2012.12.014. [Epub ahead of print]
Jung MH, Kim HR, Park YJ, Park DS, Chung KH, Oh SM.Mutat Res. 2012 Dec
12;749(1-2):39-47. Genotoxic effects and oxidative stress induced by organic extracts of
particulate matter(PM 10)collected from a subway tunnel in Seoul, Korea.
Hammond SK, Lurmann F, Shaw GM. The Association of Ambient Air Pollution and Traffic
59
Exposures With Selected Congenital Anomalies in the San Joaquin Valley of California. Am J
Epidemiol. 2013 Mar 28. [Epub ahead of print]
Hou L, Zhang X, Dioni L, Barretta F, Dou C, Zheng Y, Hoxha M, Bertazzi PA, Schwartz J,
Wu S, Wang S, Baccarelli AA. Inhalable particulate matter and mitochondrial DNA copy
number in highly exposed individuals in Beijing, China: a repeated-measure study. Part Fibre
Toxicol. 2013 Apr 29;10(1):17. [Epub ahead of print]
Ljubimova JY, Kleinman MT, Karabalin NM, Inoue S, Konda B, Gangalum P, Markman JL,
Ljubimov AV, Black KL. Gene expression changes in rat brain after short and long exposures to
particulate matter in Los Angeles basin air: Comparison with human brain tumors. Exp Toxicol
Pathol. 2013 May 17. pii: S0940-2993(13)00054-7. doi: 10.1016/j.etp.2013.04.002. [Epub
ahead of print]
Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K,
McConnell R, Sioutas C, Finch CE, Morgan TE. PLoS One. 2013 May 29;8(5):e64128. doi:
10.1371/journal.pone.0064128. Print 2013. Prenatal exposure to urban air nanoparticles in
mice causes altered neuronal differentiation and depression- like responses.
Prasad BS, Vidyullatha P, Venkata RP, Tirumala VG, Varre S, Penagaluru UR, Grover P,
Mundluru HP, Penagaluru PR. Evaluation of oxidative stress and DNA damage in traffic
policemen exposed to vehicle exhaust. Biomarkers. 2013 Jun 5. [Epub ahead of print]
Janssen BG, Godderis L, Pieters N, Poels K, Kici Ski M, Cuypers A, Fierens F, Penders J,
Plusquin M, Gyselaers W, Nawrot TS. Placental DNA hypomethylation in association with
particulate air pollution in early life. Part Fibre Toxicol. 2013 Jun 7;10(1):22. [Epub ahead of
print]
Koehler C, Thielen S, Ginzkey C, Hackenberg S, Scherzed A, Burghartz M, Paulus M,
Hagen R, Kleinsasser NH. Nitrogen dioxide is genotoxic in urban concentrations. Inhal Toxicol.
2013 May 23. [Epub ahead of print]
Slama R, Bottagisi S, Solansky I, Lepeule J, Giorgis-Allemand L, Sram R. Short-Term
Impact of Atmospheric Pollution on Fecundability. Epidemiology. 2013 Sep 18. [Epub ahead of
print]
Demarini DM. Genotoxicity biomarkers associated with exposure to traffic and near-road
atmospheres: a review. Mutagenesis. 2013 Sep;28(5):485-505. doi: 10.1093/ mutage/get042.
Perera F, et al. Prenatal Exposure to Air Pollution, Maternal Psychological Distress, and
Child Behavior. Pediatrics, October 2013,
Demarini DM. Genotoxicity biomarkers associated with exposure to traffic and near-road
atmospheres: a review. Mutagenesis. 2013 Sep;28(5):485-505. doi: 10.1093/ mutage/get042.
Bass V, Gordon CJ, Jarema KA, Macphail RC, Cascio WE, Phillips PM, Ledbetter AD,
Schladweiler MC, Andrews D, Miller D, Doerfler DL, Kodavanti UP. Ozone Induces Glucose
60
Intolerance and Systemic Metabolic Effects in Young and Aged Brown Norway Rats. Toxicol
Appl Pharmacol. 2013 Oct 5. pii: S0041-008X(13)00429-8. doi: 10.1016/ j.taap.2013.09.029.
[Epub ahead of print]
Weldy CS, Y Liu, YC Chang, IO Medvedev, JR Fox, TV Larson, WM Chien, MT Chin. In
utero and early life exposure to diesel exhaust air pollution increases adult susceptibility to
heart failure in mice. Particle and Fibre Toxicology. 2013. http://bit.ly/ 18znRIR
Guo L, Byun HM, Zhong J, Motta V, Barupal J, Zheng Y, Dou C, Zhang F, McCracken JP,
Diaz A, Marco SG, Colicino S, Schwartz J, Wang S, Hou L, Baccarelli AA. Effects of short-term
exposure to inhalable particulate matter on DNA methylation of tandem repeats. Environ Mol
Mutagen. 2014 Jan 17. doi: 10.1002/em.21838. [Epub ahead of print]
Shang Y1, Zhang L1, Jiang Y1, Li Y2, Lu P3. Airborne quinones induce cytotoxicity and
DNA damage in human lung epithelial A549 cells: The role of reactive oxygen species.
Chemosphere. 2014 Jan 27.pii:S0045-6535(14)00016-2. doi: 10.1016/ j.chemosphere.
2013.12.079. [Epub ahead of print]
de Kok TM, Driece HA, Hogervorst JG, Briedé JJ. Toxicological assessment of ambient and
traffic-related particulate matter: a review of recent studies. Mutat Res. 2006 Nov-Dec;
613(2-3):103-22. Epub 2006 Sep 1.
XU DQ, ZHANG W. Monitoring of Pollution of Air Fine Particles (PM2.5) and Study on
Their Genetic Toxicity BIOMEDICAL AND ENVIRONMENTAL SCIENCES 17, 452-458(2004)
Yu-Ting L, Yungling L, Chau-Ren J, et al. Air pollution and limb defects: A matched- pairs
case-control study in Taiwan. Environmental Research. Volume 132, July 2014, Pages 273–280
Wick P, Malek A, Manser P, Meili D, Maeder-Althaus X, Diener L, et al. 2010. Barrier
capacity of human placenta for nanosized materials. Environ Health Perspect 118:432-436.
Brocato J, Sun H, Shamy M, Kluz T, Alghamdi MA, Khoder MI, Chen LC, Costa M.
Particulate matter from Saudi Arabia induces genes involved in inflammation, metabolic
syndrome and atherosclerosis. J Toxicol Environ Health A. 2014;77(13):751-66. doi:
10.1080/15287394.2014.892446.
Fossati S, Baccarelli A, Zanobetti A, Hoxha M, Vokonas PS, Wright RO, Schwartz J.
Ambient particulate air pollution and microRNAs in elderly men. Epidemiology. 2014 Jan;
25(1):68-78. doi: 10.1097/EDE.0000000000000026.
Tao MH, Zhou J, Rialdi AP, Martinez R, Dabek J, Scelo G, Lissowska J, Chen J, Boffetta P.
Indoor air pollution from solid fuels and peripheral Blood DNA methylation: Findings from a
population study in Warsaw, Poland. Environ Res. 2014 Sep 5;134C:325-330. doi: 10.1016/
j.envres.2014.08.017. [Epub ahead of print]
Jedrychowski W, et al. Gender differences in fetal growth of newborns exposed prenatally to
airborne fine particulate matter. Environmental Research. Volume 109, Issue 4, May 2009,
61
Pages 447–456
Sancini G, Farina F, Battaglia C, Cifola I, Mangano E, Mantecca P, Camatini M, Palestini
P. Health Risk Assessment for Air Pollutants: Alterations in Lung and Cardiac Gene Expression
in Mice Exposed to Milano Winter Fine Particulate Matter (PM2.5). PLoS One. 2014 Oct
8;9(10):e109685. doi: 10.1371/journal.pone.0109685. eCollection 2014.
Neophytou AM, Hart JE, Chang Y, Zhang JJ, Smith TJ, Garshick E, Laden F. Short-term
traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage.
Toxics. 2014 Sep;2(3):377-390.
Farhia A, et al. The possible association between exposure to air pollution and the risk for
congenital malformations. Environmental Research, Volume 135, November 2014, Pages 173–
180
Morales E, et al. Intrauterine and early postnatal exposure to outdoor air pollution and lung
function at preschool age. Thorax, 2014; DOI: 10.1136/thoraxjnl-2014-205413
Bolton JL, Auten RL, Bilbo SD. Prenatal air pollution exposure induces sexually dimorphic
fetal programming of metabolic and neuroinflammatory outcomes in adult offspring. Brain
Behav Immun. 2014 Mar;37:30-44. doi: 10.1016/j.bbi.2013.10.029. Epub 2013 Nov 1.
Carmona JJ, Sofer T, Hutchinson J, Cantone L, Coull B, Maity A, Vokonas P, Lin X,
Schwartz J, Baccarelli AA. Short-term airborne particulate matter exposure alters the
epigenetic landscape of human genes associated with the mitogen-activated protein kinase
network: a cross-sectional study. Environ Health. 2014 Nov 13;13(1):94. [Epub ahead of print]
Møller P, Danielsen PH, Karottki DG, Jantzen K, Roursgaard M, Klingberg H, Jensen DM,
Christophersen DV, Hemmingsen JG, Cao Y, Loft S. Oxidative stress and inflammation
generated DNA damage by exposure to air pollution particles. Mutat Res Rev Mutat Res. 2014
October – December;762C:133-166. doi: 10.1016/j.mrrev. 2014.09.001. Epub 2014 Sep 16.
Fan T, Fang SC, Cavallari JM, Barnett IJ, Wang Z, Su L, Byun HM, Lin X, Baccarelli AA,
Christiani DC. Heart rate variability and DNA methylation levels are altered after short-term
metal fume exposure among occupational welders: a repeated-measures panel study. BMC
Public Health. 2014 Dec 16;14(1):1279. [Epub ahead of print]
Bijnens E, Zeegers MP, Gielen M, Kicinski M, Hageman GJ, Pachen D, Derom C, Vlietinck
R, Nawrot TS. Lower placental telomere length may be attributed to maternal residential traffic
exposure; a twin study. Environ Int. 2015 Mar 7;79:1-7. doi: 10.1016/j.envint.2015.02.008.
[Epub ahead of print]
Jurewicz J, Radwan M, Sobala W, Polańska K, Radwan P, Jakubowski L, Ulańska A, Hanke
W. The relationship between exposure to air pollution and sperm disomy. Environ Mol
Mutagen. 2015 Jan;56(1):50-9. doi: 10.1002/em.21883. Epub 2014 Jul 3.
Seamen N, et al. In Utero Fine Particle Air Pollution and Placental Expression of Genes in
62
the Brain-Derived Neurotrophic Factor Signaling Pathway: An ENVIRONAGE Birth Cohort
Study. Environ Health Perspect; DOI:10.1289/ehp.1408549
Janssen BG, Byun HM, Gyselaers W, Lefebvre W, Baccarelli AA, Nawrot TS. Placental
mitochondrial methylation and exposure to airborne particulate matter in the early life
environment: An ENVIRONAGE birth cohort study. Epigenetics. 2015 May 21:0. [Epub ahead
of print]
Kim JT, Son MH, Lee DH, Seong WJ, Han S, Chang YS. Partitioning Behavior of Heavy
Metals and Persistent Organic Pollutants among Feto-Maternal Bloods and Tissues. Environ
Sci Technol. 2015 Jun 16;49(12):7411-22. doi: 10.1021/es5051309. Epub 2015 Jun 5.
Duan H, et al. Long-term exposure to diesel engine exhaust induces primary DNA damage:
a population-based study. Occup Environ Med. 2015 Oct 21. pii: oemed-2015-102919. doi:
10.1136/oemed-2015-102919. [Epub ahead of print]
Grevendonk L, et al. Mitochondrial oxidative DNA damage and exposure to particulate air
pollution in mother-newborn pairs. Environmental Health 2016, 15:10
Hou L, et al. Particulate Air Pollution Exposure and Expression of Viral and Human
MicroRNAs in Blood: The Beijing Truck Driver Air Pollution Study. Environ Health Perspect;
DOI:10.1289/ehp.1408519
Abbas I, et al. In vitro short-term exposure to air pollution PM2.5-0.3 induced cell cycle
alterations and genetic instability in a human lung cell coculture model. Environ Res. 2016 Feb
10;147:146-158. doi: 10.1016/j.envres.2016.01.041. [Epub ahead of print]
Tsamou M, et al. Air pollution-induced placental epigenetic alterations in early life: a
candidate miRNA approach. Epigenetics. 2016 Apr 22:0. [Epub ahead of print]
Liu CB, et al. Effects of Prenatal PM10 Exposure on Fetal Cardiovascular Malformations
in Fuzhou, China: A Retrospective Case-Control Study. Environ Health Perspect. 2016 Jul 6.
[Epub ahead of print]
Martens DS, Nawrot TS. Air Pollution Stress and the Aging Phenotype: The Telomere
Connection. Curr Environ Health Rep. 2016 Jun 29. [Epub ahead of print]
Veras MM, et al. Before the first breath: prenatal exposures to air pollution and lung
development. Cell Tissue Res. 2016 Oct 10. [Epub ahead of print]
Ding R, et al. Dose- and time- effect responses of DNA methylation and histone H3K9
acetylation changes induced by traffic-related air pollution. Sci Rep. 2017 Mar 3;7:43737. doi:
10.1038/srep437
Lin N, et al. Accumulative effects of indoor air pollution exposure on leukocyte telomere
length among non-smokers. Environ Pollut. 2017 Apr 24;227:1-7. doi: 10.1016/j.envpol.
2017.04.054. [Epub ahead of print]
Lai CH, et al. Exposure to fine particulate matter causes oxidative and methylated DNA
63
damage in young adults: A longitudinal study. Sci Total Environ. 2017 Apr 23;598:289-296.
doi: 10.1016/j.scitotenv.2017.04.079. [Epub ahead of print]
Lee E, et al. Traffic-Related Air Pollution and Telomere Length in Children and
Adolescents Living in Fresno, CA. Journal of Occupational and Environmental Medicine, 2017;
59 (5): 446 DOI: 10.1097/JOM.0000000000000996
Mao G, et al. Individual and Joint Effects of Early-Life Ambient PM2.5 Exposure and
Maternal Prepregnancy Obesity on Childhood Overweight or Obesity. Environ Health
Perspect; DOI:10.1289/EHP261
de Oliveira A, et al. Biomass burning in the Amazon region causes DNA damage and cell
death in human lung cells. Sci Rep. 2017 Sep 7;7(1):10937. doi: 10.1038/s41598-017-11024-3.
Kingsley SL, et al. Maternal residential air pollution and placental imprinted gene
expression. Environ Int. 2017 Sep 5;108:204-211. doi: 10.1016/j.envint.2017.08.022. [Epub
ahead of print]
Huang Q, et al. Fine particulate matter 2.5 exerted its toxicological effect by regulating a
new layer, long non-coding RNA. Sci Rep. 2017 Aug 24;7(1):9392. doi: 10.1038/
s41598-017-09818-6.
Goodson J, et al. In utero exposure to diesel exhaust particulates is associated with an
altered cardiac transcriptional response to transverse aortic constriction and altered DNA
methylation. The FASEB Journal, 2017; fj.201700032R DOI: 10.1096/fj.201700032R
Martens DS, et al. Prenatal Air Pollution and Newborns’ Predisposition to Accelerated
Biological Aging. JAMA Pediatr. 2017 Oct 16. doi: 10.1001/jamapediatrics.2017.3024. [Epub
ahead of print]
Qiu L, et al. Exposure to Concentrated Ambient PM2.5 Compromises Spermatogenesis in
a Mouse Model: Role of Suppression of Hypothalamus-Pituitary-Gonads Axis. Toxicol Sci.
2017 Nov 20. doi: 10.1093/toxsci/kfx261. [Epub ahead of print]
Ren S, et al. Periconception Exposure to Air Pollution and Risk of Congenital
Malformations. The Journal of Pediatrics, 2017; DOI: 10.1016/j.jpeds.2017.09.076
Mahalingaiah S, et al. Perimenarchal air pollution exposure and menstrual disorders.
Human Reproduction, 2018; DOI: 10.1093/humrep/dey005
Zhou N, et al. Exposures to Atmospheric PM10 and PM10-2.5 Affect Male Semen
Quality: Results of MARHCS Study. Environ Sci Technol. 2018 Jan 11. doi: 10.1021/acs.est.
7b05206. [Epub ahead of print]
Radwan M, et al. Air Pollution and Human Sperm Sex Ratio. Am J Mens Health. 2018
Jan 1:1557988317752608. doi: 10.1177/1557988317752608. [Epub ahead of print]
Nemmar A, et al. Thrombosis, systemic and cardiac oxidative stress and DNA damage
induced by pulmonary exposure to diesel exhaust particles, and the effect of nootkatone thereon.
64
Am J Physiol Heart Circ Physiol. 2018 Jan 5. doi: 10.1152/ajpheart.00313.2017. [Epub ahead
of print]
Chen R, et al. Fine Particulate Air Pollution and the Expression of microRNAs and
Circulating Cytokines Relevant to Inflammation, Coagulation, and Vasoconstriction. Environ
Health Perspect. 2018 Jan 17;126(1):017007. doi: 10.1289/EHP1447.
Krauskopf J, Caiment F, van Veldhoven K, Chadeau-Hyam M, Sinharay R, Chung KF,
Cullinan P, Collins P, Barratt B, Kelly FJ, Vermeulen R, Vineis P, de Kok TM, Kleinjans JC.
The human circulating miRNome reflects multiple organ disease risks in association with shortterm
exposure to traffic-related air pollution. Environ Int. 2018 Jan 27;113:26-34. doi:
10.1016/j.envint.2018.01.014. [Epub ahead of print] PMID: 29421404 [PubMed – as supplied
by publisher]
Jie Y, et al. Changes in gene expression in lungs of mice exposed to traffic-related air
pollution.Mol Cell Probes. 2018 Apr 2. pii: S0890-8508(18)30034-3. doi: 10.1016/j.mcp.
2018.03.005. [Epub ahead of print].
Plusquin M, et al. DNA methylome marks of exposure to particulate matter at three time
points in early life. Environ Sci Technol. 2018 Mar 30. doi: 10.1021/acs.est.7b06447. [Epub
ahead of print]
Favé M-J, et al. Gene-by-environment interactions in urban populations modulate risk
phenotypes. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-03202-2
Domingues ÉP, et al. Genotoxic effects following exposure to air pollution in street
vendors from a high-traffic urban area. Environ Monit Assess. 2018 Mar 14;190(4):215. doi:
10.1007/s10661-018-6598-2.
Bosco L, et al. Sperm DNA fragmentation: An early and reliable marker of air
pollution.Environ Toxicol Pharmacol. 2018 Feb 7;58:243-249. doi: 10.1016/j.etap.2018.02.001.
[Epub ahead of print]
Maghbooli Z, et al. Air pollution during pregnancy and placental adaptation in the levels
of global DNA methylation. PLoS One. 2018 Jul 6;13(7):e0199772. doi: 10.1371/journal.pone.
eCollection 2018.
Peng C, et al. Residential Proximity to Major Roadways at Birth, DNA Methylation at
Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts,
USA) Published: 18 September 2018, DOI: https://doi.org/10.1289/EHP2034
Ledda C, et al. Mutagenic and DNA repair activity in traffic policemen: a case-crossover
study.J Occup Med Toxicol. 2018 Aug 8;13:24. doi: 10.1186/s12995-018-0206-9. eCollection
2018.
He T, et al. Ambient air pollution, H19/DMR methylation in cord blood and newborn size:
A pilot study in Zhengzhou City, China. Chemosphere. 2018 Aug 30;212:863-871. doi:
65
10.1016/j.chemosphere.2018.08.140. [Epub ahead of print]
Zhao B, et al. Air pollution and telomere length: a systematic review of 12,058 subjects.
Cardiovasc Diagn Ther. 2018 Aug;8(4):480-492. doi: 10.21037/cdt.2018.06.05.
Tanwar V, et al. Preconception Exposure to Fine Particulate Matter Leads to Cardiac
Dysfunction in Adult Male Offspring. Journal of the American Heart Association, 2018; 7 (24)
DOI: 10.1161/JAHA.118.010797
Stapleton P. Should Perturbation of the Preconceptive Environment be Considered a Risk
Factor for the Development of Cardiovascular Disease Later in Life? J Am Heart Assoc. 2018
Dec 18;7(24):e011249. doi: 10.1161/JAHA.118.011249.
Alvarado-Cruz I, et al. Environmental Epigenetic Changes, as Risk Factors for the
Development of Diseases in Children: A Systematic Review. Ann Glob Health. 2018 Jul
27;84(2):212-224. doi: 10.29024/aogh.909.
Goodson JM, et al. In utero exposure to diesel exhaust is associated with alterations in
neonatal cardiomyocyte transcription, DNA methylation and metabolic perturbation. Part
Fibre Toxicol. 2019 Apr 11;16(1):17. doi: 10.1186/s12989-019-0301-9.
Current Opinion in Pediatrics:
April 2009 – Volume 21 – Issue 2 – p 243-251
doi: 10.1097/MOP.0b013e32832925cc
Therapeutics and toxicology: Edited by Robert O. Wright Epigenetics and environmental
chemicals
Baccarelli, Andrea; Bollati, Valentina
http://www.newsweek.com/2010/10/30/how-your-experiences-change-your-sperm-andeggs.
html

#

Pollution and the Lung

Air pollution permanently inhibits lung growth in children. In fact prenatal exposure can reduce fetal lung development, impairing lung function in childhood and permanently reducing the number of alveoli (air sacs) in the lungs.
Brief exposure to ozone and particulate matter reduce lung function even in young healthy adults and the reduction can last for a week after the pollution exposure is over.
Air pollution causes lung cancer.
Long term ozone exposure causes an increase in overall mortality in addition to that
from particulate matter. Most of the mortality is respiratory.
Air pollution exacerbates virtually all pulmonary diseases and likely plays a causative
role in reactive airways disease, and some cases of COPD.
Air pollution is associated with increased rates of serious lower respiratory infections,
and hospitalization and death from most respiratory diseases from neonates to the elderly.
The correlation between the above health outcomes and ozone are still found at concentrations between one half and one third the current EPA NAAQS.
*Air pollution causes DNA damage and cell death to lung cells.

Schelegle, E., Morales, C., Walby, W., et al, 6.6 Hour Inhalation of Ozone Concentrations
from 60 to 87 Parts per Billion in Healthy Humans. American Journal of Respiratory and
Critical Care Medicine Vol 180. pp 265-272, (2009).
Thaller, E., Petronella, S., Hochman, D. et al. Moderate increases in Ambient PM 2.5 and
Ozone Are Associated With Lung Function Decreases in Beach Lifeguards. Journal of
Occupational and Environmental Medicine. 50(2):202-211, Feb. 2008.
Gauderman WJ, Gilliland GF, Vora H, et al. Association between Air Pollution and Lung
Function Growth in Southern California Children: results from a second cohort. Am J Respir
Crit Care Med 2002;166:76-84.
67
Gauderman WJ, Gilliland GF, Vora H, et al. The effect of air pollution on lung development
from 10 to 18 years of age. NEJM 2004;351:1057-67.
Wichmann et al. Increased asthma and respiratory symptoms in children exposed to
petrochemical pollution. Journal of Allergy and Clinical Immunology, 2009; 123 (3): 632 DOI:
10.1016/j.jaci.2008.09.052
Jerrett M, Burnett R, Pope CA, et al. Long-Term Ozone Exposure and Mortality. NEJM. Vol.
360:1085-1095. March 12, 2009 Num 11.
Zuurbier M, Hoek G, Oldenwening M, Meliefste K, van den Hazel P, Brunekreef B.
Respiratory Effects of Commuters’ Exposure to Air Pollution in Traffic. Epidemiology. 2011 Jan
[Epub ahead of print]
Faustini A, Stafoggia M, Berti G, Bisanti L, Chiusolo M, Cernigliaro A, Mallone S,
Primerano R, Scarnato C, Simonato L, Vigotti MA, Forastiere F; The relationship between
ambient particulate matter and respiratory mortality: a multi-city study in Italy. Eur Respir J.
2011 Jan 13. [Epub ahead of print]
Forbes LJ, Kapetanakis V, Rudnicka AR, Cook DG, Bush T, Stedman JR, Whincup PH,
Strachan DP, Anderson HR. Chronic exposure to outdoor air pollution and lung function in
adults. Thorax. 2009 Aug;64(8):657-63. Epub 2009 Apr 8.
Chong S Kim1*, Neil E Alexis2, Ana G Rappold1, Howard Kehrl1, Milan J Hazucha2, John
C Lay2, Mike T Schmitt1, Martin Case1, Robert B Devlin1, David B Peden2, and David Diaz-
Sanchez1 Lung Function and Inflammatory Responses in Healthy Young Adults Exposed to 0.06
ppm Ozone for 6.6 Hours. Published ahead of print on January 7, 2011. Am. J. Respir. Crit.
Care Med. 2011, doi:10.1164/rccm. 201011-1813OC
Steinvil A, Fireman E, Kordova-Biezuner L, Cohen M, Shapira I, Berliner S, Rogowski O.
Environmental air pollution has decremental effects on pulmonary function test parameters up
to one week after exposure. Am J Med Sci. 2009 Oct; 338(4):273-9.
Karr CJ, Demers P, Koehoorn M, Lencar C, Tamburic L, Brauer M. Influence of Ambient
Air Pollutant Sources on Clinical Encounters for Infant Bronchiolitis. Am. J. Respir. Crit. Care
Med., Nov 2009; 180: 995 – 1001.
Hollingsworth, J.W. et al. (2007) Ozone and pulmonary innate immunity. Proc. Am. Thorac.
Soc. 4, 240–246
Strickland M, Darrow L, et al. Short Term Associations between Ambient Air Pollutants and
Pediatric Asthma Emergency Department Visits. Am J Respir Crit Care Med Vol 182
pp307-316, 2010
Stafoggia M, Forastiere F, et al. Susceptibility Factors to Ozone Related Mortality Am J
Respir Crit Care Med Vol 182 pp 376-384, 2010
Bell ML, Peng RD, Dominici F. The exposure-response curve for ozone and risk of mortality
68
and the adequacy of current ozone regulations. Environ Health Perspect 2006;114:532-536.
Mushtaq N, Ezzati M, Hall L, Dickson I, Kirwan M, Png KM, Mudway IS, Grigg J. Adhesion
of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate
matter. J Allergy Clin Immunol. 2011 Jan 17. [Epub ahead of print]
Andersen Z, Hvidberg M, Jensen S, et al. Chronic Obstructive Pulmonary Disease and
Long-Term Exposure to Traffic-Related Air Pollution: A Cohort Study. Am. J. Respir. Crit. Care
Med. 2010, doi:10.1164/rccm.201006-0937OC. Published ahead of print on September 24,
2010
Raaschou-Nielsen O, Andersen Z, Hvidberg M, Jensen SS, Ketzel M, Sørensen M, et al.
Lung Cancer Incidence and Long-Term Exposure to Air Pollution from Traffic. Environ
Health Perspect :-. doi:10.1289/ehp.1002353
Spira-Cohen A, Chen L-C, Kendall M, Lall R, Thurston GD 2011. Personal Exposures to
Traffic-Related Air Pollution and Acute Respiratory Health Among Bronx School Children with
Asthma. Environ Health Perspect :-. doi:10.1289/ehp.1002653
Franck U, Herbarth O, Röder S, Schlink U, Borte M, Diez U, Krämer U, Lehmann I.
Respiratory effects of indoor particles in young children are size dependent. Sci Total Environ.
2011 Feb 10. [Epub ahead of print]
Minelli C, Wei I, Sagoo G, Jarvis D, Shaheen S, Burney P. Interactive Effects of Antioxidant
Genes and Air Pollution on Respiratory Function and Airway Disease: A Huge Review. Am J
Epidemiol. 2011 Feb 22. [Epub ahead of print].
N. Li, J. R. Harkema, R. P. Lewandowski, M. Wang, L. A. Bramble, G. R. Gookin, Z. Ning,
M. T. Kleinman, C. Sioutas, A. E. Nel. Ambient Ultrafine Particles Provide a Strong Adjuvant
Effect in the Secondary Immune Response: Implication for Traffic-related Asthma Flares. AJP:
Lung Cellular and Molecular Physiology, 2010; DOI: 10.1152/ ajplung.00115.2010
Nawrot TS, Vos R, Jacobs L, Verleden SE, Wauters S, Mertens V, Dooms C, Hoet PH, Van
Raemdonck DE, Faes C, Dupont LJ, Nemery B, Verleden GM, Vanaudenaerde BM. The impact
of traffic air pollution on bronchiolitis obliterans syndrome and mortality after lung
transplantation. Thorax. 2011 Mar 23. [Epub ahead of print]
Son J-Y, Bell ML, Lee J-T 2011. Survival Analysis of Long-Term Exposure to Different Sizes
of Airborne Particulate Matter and Risk of Infant Mortality Using a Birth Cohort in Seoul,
Korea. Environ Health Perspect 119:725-730. doi:10.1289/ehp. 1002364
Zuurbier, M, G Hoek, M Oldenwening, K Meliefste, P van den Hazel and B Brunekreef.
Respiratory effects of commuters’ exposure to air pollution in traffic. Epidemiology http://
dx.doi.org/10.1097/EDE.0b013e3182093693.
Factor P, Akhmedov AT, McDonald JD, Qu A, Wu J, Jiang H, Dasgupta T, Panettieri Jr RA,
Perera F, Miller RL. Polycyclic Aromatic Hydrocarbons Impair {beta}2AR Function in Airway
69
Epithelial and Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2011 May 26. [Epub ahead of
print]
Pope CA 3rd, Burnett RT, Turner MC, Cohen AJ, Krewski D, Jerrett M, Gapstur SM, Thun
MJ. Lung Cancer and Cardiovascular Disease Mortality Associated with Ambient Air Pollution
and Cigarette Smoke: Shape of the Exposure-Response Relationships. Environ Health Perspect.
2011 Jul 19. [Epub ahead of print]
Peters S, Kromhout H, Olsson AC, Wichmann HE, Brüske I, Consonni D, Landi MT,
Caporaso N, Siemiatycki J, Richiardi L, Mirabelli D, Simonato L, Gustavsson P, Plato N, Jöckel
KH, Ahrens W, Pohlabeln H, Boffetta P, Brennan P, Zaridze D, Cassidy A, Lissowska J,
Szeszenia-Dabrowska N, Rudnai P, Fabianova E, Forastiere F, Bencko V, Foretova L, Janout
V, Stücker I, Dumitru RS, Benhamou S, Bueno-de-Mesquita B, Kendzia B, Pesch B, Straif K,
Brüning T, Vermeulen R. Occupational exposure to organic dust increases lung cancer risk in
the general population. Thorax. 2011 Aug 19. [Epub ahead of print]
Peel JL, Klein M, Flanders WD, Mulholland JA, Freed G, Tolbert PE 2011. Ambient Air
Pollution and Apnea and Bradycardia in High-Risk Infants on Home Monitors. Environ Health
Perspect 119:1321-1327. http://dx.doi.org/10.1289/ehp.1002739
Chiusolo M, Cadum E, Stafoggia M, Galassi C, Berti G, Faustini A, et al. 2011. Short-Term
Effects of Nitrogen Dioxide on Mortality and Susceptibility Factors in 10 Italian Cities: The
EpiAir Study. Environ Health Perspect 119:1233-1238. http:// dx.doi.org/10.1289/ehp.1002904
Andersen ZJ, Bønnelykke K, Hvidberg M, Jensen SS, Ketzel M, Loft S, Sørensen M,
Tjønneland A, Overvad K, Raaschou-Nielsen O. Long-term exposure to air pollution and
asthma hospitalisations in older adults: a cohort study. Thorax. 2011 Sep 2. [Epub ahead of
print]
Esplugues A, Ballester F, Estarlich M, Llop S, Fuentes-Leonarte V, Mantilla E, Vioque J,
Iñiguez Outdoor, but not indoor, nitrogen dioxide exposure is associated with persistent cough
during the first year of life. C.Sci Total Environ. 2011 Sep 1. [Epub ahead of print]
Franzi LM, Bratt JM, Williams KM, Last JA. Why is particulate matter produced by
wildfires toxic to lung macrophages? Toxicol Appl Pharmacol. 2011 Sep 16. [Epub ahead of
print].
Turner MC, Krewski D, Pope Iii CA, Chen Y, Gapstur SM, Thun MJ. Long-Term Ambient
Fine Particulate Matter Air Pollution and Lung Cancer in a Large Cohort of Never Smokers.
Am J Respir Crit Care Med. 2011 Oct 6. [Epub ahead of print]
Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG. Diesel
Exhaust Particulates Exacerbate Asthmalike Inflammation by Increasing CXC Chemokines. Am
J Pathol. 2011 Sep 30. [Epub ahead of print]
Chang YK, Wu CC, Lee LT, Lin RS, Yu YH, Chen YC. The short-term effects of air pollution
70
on adolescent lung function in Taiwan. Chemosphere. 2011 Dec 19. [Epub ahead of print]
Bernstein DI. Traffic-Related Pollutants and Wheezing in Children. J Asthma. 2012 Jan 3.
[Epub ahead of print]
Ghosh R, Joad J, Benes I, Dostal M, Sram RJ, Hertz-Picciotto I. Ambient nitrogen oxides
exposure and early childhood respiratory illnesses. Environ Int. 2012 Feb;39(1): 96-102. Epub
2011 Nov 11.
Brandt SJ, Perez L, Künzli N, Lurmann F, McConnell R. Costs of childhood asthma due to
traffic-related pollution in two California communities. Eur Respir J. 2012 Jan 26. [Epub ahead
of print]
Yi S, Zhang F, Qu F, Ding W. Water-insoluble fraction of airborne particulate matter
(PM(10) ) induces oxidative stress in human lung epithelial A549 cells. Environ Toxicol. 2012
Feb 13. doi: 10.1002/tox.21750. [Epub ahead of print]
Liu X, Lessner L, Carpenter DO. Association between Residential Proximity to Fuel-Fired
Power Plants and Hospitalization Rate for Respiratory Diseases. Environ Health Perspect.
2012 Feb 27. [Epub ahead of print]
Chan J, . Fanucchi M, Anderson D, et al. Susceptibility of Inhaled Flame- Generated
Ultrafine Soot in Neonatal and Adult Rat Lungs. Toxicological Sciences. 124:472-486. doi:
10.1093/toxsci/kfr233
Cornell A, Chillrud S, Mellins R, et al. Domestic airborne black carbon and exhaled nitric
oxide in children in NYC. Journal of Exposure Science and Environmental Epidemiology, 2012;
DOI: 10.1038/jes.2012.3
Canova C, Dunster C, Kelly FJ, Minelli C, Shah PL, Caneja C, Tumilty MK, Burney P.
PM10-induced Hospital Admissions for Asthma and Chronic Obstructive Pulmonary Disease:
The Modifying Effect of Individual Characteristics. Epidemiology. 2012 Apr 23. [Epub ahead of
print]
Strak M, Janssen NA, Godri KJ, Gosens I, Mudway IS, Cassee FR, Lebret E, Kelly FJ,
Harrison RM, Brunekreef B, Steenhof M, Hoek G. Respiratory Health Effects of Airborne
Particulate Matter: The Role of Particle Size, Composition and Oxidative Potential – The
RAPTES Project. Environ Health Perspect. 2012 May 2. [Epub ahead of print]
Brown MS, Sarnat SE, Demuth KA, Brown LA, Whitlock DR, Brown SW, Tolbert PE,
Fitzpatrick AM. Residential proximity to a major roadway is associated with features of asthma
control in children. PLoS One. 2012;7(5):e37044. Epub 2012 May 17.
Lin S, Jones R, Pantea C, Ozkaynak H, Rao ST, Hwang SA, Garcia VC.
Impact of NO(x) emissions reduction policy on hospitalizations for respiratory disease in New
York State. J Expo Sci Environ Epidemiol. 2012 Jul 25. doi: 10.1038/jes.2012.69. [Epub ahead
of print]
71
Svendsen ER, Gonzales M, Mukerjee S, Smith L, Ross M, Walsh D, Rhoney S, Andrews G,
Ozkaynak H, Neas LM. GIS-Modeled Indicators of Traffic-Related Air Pollutants and Adverse
Pulmonary Health Among Children in El Paso, Texas. Am J Epidemiol. 2012 Oct 1;176 Suppl
7:S131-41. doi: 10.1093/aje/kws274.
Lin, S, R Jones, C Pantea, H Ozkaynak, ST Rao, S Hwang and VC Garcia. 2012. Impact of
NOx emissions reduction policy on hospitalizations for respiratory disease in New York State.
Journal of Exposure Science and Environmental Epidemiology http:// dx.doi.org/10.1038/jes.
2012.69.
Kyung SY, Yoon JY, Kim YJ, Lee SP, Park JW, Jeong SH. Asian Dust Particles Induce TGF-
β(1) via Reactive Oxygen Species in Bronchial Epithelial Cells. Tuberc. Respir Dis (Seoul).
2012 Aug;73(2):84-92. doi: 10.4046/trd.2012.73.2.84. Epub 2012 Aug 31.
Zhu R, Chen Y, Wu S, Deng F, Liu Y, Yao W. The Relationship between Particulate Matter
(PM(10)) and Hospitalizations and Mortality Of Chronic Obstructive Pulmonary Disease: A
Meta-Analysis. COPD. 2013 Jan 16. [Epub ahead of print]
Kim BJ, Seo JH, Jung YH, Kim HY, Kwon JW, Kim HB, Lee SY, Park KS, Yu J, Kim HC,
Leem JH, Lee JY, Sakong J, Kim SY, Lee CG, Kang DM, Ha M, Hong YC, Kwon HJ, Hong SJ.
Air pollution interacts with past episodes of bronchiolitis in the development of asthma. Allergy.
2013 Jan 25. doi: 10.1111/all.12104. [Epub ahead of print]
Gan WQ, Fitzgerald JM, Carlsten C, Sadatsafavi M, Brauer M. Associations of Ambient Air
Pollution with Chronic Obstructive Pulmonary Disease Hospitalization and Mortality. Am J
Respir Crit Care Med. 2013 Feb 7. [Epub ahead of print]
Wright RJ, Brunst KJ. Programming of respiratory health in childhood: influence of outdoor
air pollution. Curr Opin Pediatr. 2013 Feb 15. [Epub ahead of print]
Dong GH, Qian ZM, Liu MM, Wang D, Ren WH, Bawa S, Fu J, Wang J, Lewis R, Zelicoff A,
Simckes M, Trevathan E. Breastfeeding as a Modifier of the Respiratory Effects of Air Pollution
in Children. Epidemiology. 2013 Feb 20. [Epub ahead of print]
Farhat SC, Almeida MB, Silva-Filho LV, Farhat J, Rodrigues JC, Braga AL. Ozone is
associated with an increased risk of respiratory exacerbations in cystic fibrosis patients. Chest.
2013 Mar 14. doi: 10.1378/chest.12-2414. [Epub ahead of print]
Skrzypek M, Zejda JE, Kowalska M, Czech EM.AM, Tager IB, Carmichael SL, Int J Occup
Med Environ Health. 2013 Mar 22. [Epub ahead of print] Effect of residential proximity to
traffic on respiratory disorders in school children in upper Silesian Industrial Zone, Poland.
Rowan-Carroll A, Halappanavar S, Williams A, Somers CM, Yauk CL. Mice exposed in situ
to urban air pollution exhibit pulmonary alterations in gene expression in the lipid droplet
synthesis pathways. Environ Mol Mutagen. 2013 Mar 27. doi: 10.1002/ em.21768. [Epub ahead
of print]
72
Perez L, et al. Chronic burden of near-roadway traffic pollution in 10 European cities
(APHEKOM network). European Respiratory Journal, 22 March 2013 DOI:
10.1183/09031936.00031112
Vattanasit U, Navasumrit P, Khadka MB, Kanitwithayanun J, Promvijit J, Autrup H,
Ruchirawat M. Oxidative DNA damage and inflammatory responses in cultured human cells
and in humans exposed to traffic-related particles. Int J Hyg Environ Health. 2013 Mar 15. pii:
S1438-4639(13)00040-0. doi: 10.1016/j.ijheh.2013.03.002. [Epub ahead of print]
LiP,XinJ,WangY,WangS,LiG,PanX,LiuZ,WangL. The acute effects of fine particles on
respiratory mortality and morbidity in Beijing, 2004-2009. Environ Sci Pollut Res Int. 2013 Apr
[Epub ahead of print]
Stern G, Latzin P, Röösli M, Fuchs O, Proietti E, Kuehni C, Frey U. A Prospective Study of
the Impact of Air Pollution on Respiratory Symptoms and Infections in Infants. Am J Respir Crit
Care Med. 2013 Apr 17. [Epub ahead of print]
Steinvil A, Shmueli H, Ben-Assa E, Leshem-Rubinow E, Shapira I, Berliner S, Kordova-
Biezuner L, Rogowski O. Environmental exposure to combustion-derived air pollution is
associated with reduced functional capacity in apparently healthy individuals. Clin Res Cardiol.
2013 Apr 26. [Epub ahead of print]
Hystad P, Demers PA, Johnson KC, Carpiano RM, Brauer M. Long-term Residential
Exposure to Air Pollution and Lung Cancer Risk. Epidemiology. 2013 May 14. [Epub ahead of
print]
Mölter A, Agius RM, de Vocht F, Lindley S, Gerrard W, Lowe L, Belgrave D, Custovic A,
Simpson A. Long Term Exposure to PM10 and NO2 in Association with Lung Volume and
Airway Resistance in the MAAS Birth Cohort. Environ Health Perspect. 2013 Jun 18. [Epub
ahead of print]
Stafoggia M, Samoli E, Alessandrini E, Cadum E, Ostro B, Berti G, Faustini A, Jacquemin
B, Linares C, Pascal M, Randi G, Ranzi A, Stivanello E, Forastiere F; Short-term Associations
between Fine and Coarse Particulate Matter and Hospitalizations in Southern Europe: Results
from the MED-PARTICLES Project. Environ Health Perspect. 2013 Jun 18. [Epub ahead of
print]
Tanaka T, Asai M, Yanagita Y, Nishinakagawa T, Miyamoto N, Kotaki K, Yano Y, Kozu R,
Honda S, Senjyu H. Longitudinal study of respiratory function and symptoms in a non-smoking
group of long-term officially-acknowledged victims of pollution-related illness. BMC Public
Health. 2013 Aug 17;13(1):766. [Epub ahead of print]
Jedrychowski WA, Perera FP, Maugeri U, Mroz E, Klimaszewska-Rembiasz M, Flak E,
Edwards S, Spengler JD. Effect of prenatal exposure to fine particulate matter on ventilatory
lung function of preschool children of non-smoking mothers. Paediatr Perinat Epidemiol. 2010
73
Sep;24(5):492-501. doi: 10.1111/j.1365-3016.2010.01136.x.
Acciani TH, Brandt EB, Khurana Hershey GK, Le Cras TD. Diesel Exhaust Particle
Exposure Increases Severity of Allergic Asthma in Young Mice. Clin Exp Allergy. 2013 Sep 24.
doi: 10.1111/cea.12200. [Epub ahead of print]
Saravia J, You D, Thevenot P, Lee GI, Shrestha B, Lomnicki S, Cormier SA. Early-life
exposure to combustion-derived particulate matter causes pulmonary immunosuppression.
Mucosal Immunol. 2013 Oct 30. doi: 10.1038/mi.2013.88. [Epub ahead of print]
Johannson KA, Vittinghoff E, Lee K, Balmes JR, Ji W, Kaplan GG, Kim DS, Collard HR.
Acute exacerbation of idiopathic pulmonary fibrosis associated with air pollution exposure. Eur
Respir J. 2013 Oct 31. [Epub ahead of print]
Rice MB, Ljungman PL, Wilker EH, Gold DR, Schwartz JD, Koutrakis P, Washko GR,
O’Connor GT, Mittleman MA. Short-Term Exposure to Air Pollution and Lung Function in the
Framingham Heart Study. Am J Respir Crit Care Med. 2013 Nov 7. [Epub ahead of print]
Vempilly J, Abejie B, Diep V, Gushiken M, Rawat M, Tyner TR. Exp Lung Res. 2013 Nov 18.
[Epub ahead of print] The synergetic effect of ambient PM2.5 exposure and rhinovirus infection
in airway dysfunction in asthma: A pilot observational study from the central valley of
california.
Villeneuve PJ, Jerrett M, Brenner D, Su J, Chen H, McLaughlin JR. A Case-Control Study
of Long-Term Exposure to Ambient Volatile Organic Compounds and Lung Cancer in Toronto,
Ontario, Canada. Am J Epidemiol. 2013 Nov 27. [Epub ahead of print]
Rice MB, et al. Short-Term Exposure to Air Pollution and Lung Function in the
Framingham Heart Study”, American Journal of Respiratory and Critical Care Medicine, Vol.
188, No. 11 (2013), pp. 1351-1357. doi: 10.1164/rccm.201308-1414OC
Malig B, Green S, Basu R, Broadwin R. Coarse Particles and Respiratory Emergency
Department Visits in California. Am. J. Epidemiol. (2013) doi: 10.1093/aje/ kws451 First
published online: May 31, 2013
Jung KH1, Perzanowski M2, Rundle A3, Moors K4, Yan B5, Chillrud SN6, Whyatt R7,
Camann D8, Perera FP9, Miller RL10. Polycyclic aromatic hydrocarbon exposure, obesity and
childhood asthma in an urban cohort. Environ Res. 2014 Jan;128:35-41. doi: 10.1016/j.envres.
2013.12.002. Epub 2013 Dec 27.
Nadeau K, McDonald-Hyman C, Noth EM, Pratt B, Hammond SK, Balmes J, Tager I.
Ambient air pollution impairs regulatory T-cell function in asthma. J Allergy Clin Immunol.
2010 Oct;126(4):845-852.e10. doi: 10.1016/j.jaci.2010.08.008.
Yamazaki S, Shima M, Nakadate T, Ohara T, Omori T, Ono M, Sato T, Nitta H. Association
between traffic-related air pollution and development of asthma in school children: Cohort
study in Japan. J Expo Sci Environ Epidemiol. 2014 Mar 12. doi: 10.1038/jes.2014.15. [Epub
74
ahead of print]
Szema A M, et al. Iraq Dust Is Respirable, Sharp, and Metal-Laden and Induces Lung
Inflammation With Fibrosis in Mice via IL-2 Upregulation and Depletion of Regulatory T Cells.
Journal of Occupational & Environmental Medicine: March 2014 – Volume 56 – Issue 3 – p
243–251 doi: 10.1097/JOM.0000000000000119
Deng X, Zhang F, Rui W, Long F, Wang L, Feng Z, Chen D, Ding W. PM2.5- induced
oxidative stress triggers autophagy in human lung epithelial A549 cells. Toxicol In Vitro. 2013
Sep;27(6):1762-70. doi: 10.1016/j.tiv.2013.05.004. Epub 2013 May 17.
Deng X, Zhang F, Wang L, Rui W, Long F, Zhao Y, Chen D, Ding W. Airborne fine
particulate matter induces multiple cell death pathways in human lung epithelial cells.
Apoptosis. 2014 Apr 11. [Epub ahead of print]
Mu L, Deng F, Tian L, Li Y, Swanson M, Ying J, Browne RW, Rittenhouse-Olson K, Zhang
JJ, Zhang ZF, Bonner MR. Peak expiratory flow, breath rate and blood pressure in adults with
changes in particulate matter air pollution during the Beijing Olympics: A panel study. Environ
Res. 2014 Jun 3;133C:4-11. doi: 10.1016/j.envres.2014.05.006. [Epub ahead of print]
Delfino RJ, Wu J, Tjoa T, Gullesserian SK, Nickerson B, Gillen DL. Asthma morbidity and
ambient air pollution: effect modification by residential traffic-related air pollution.
Epidemiology. 2014 Jan;25(1):48-57. doi: 10.1097/EDE.0000000000000016.
Eeftens M, Hoek G, Gruzieva O. Elemental Composition of Particulate Matter and the
Association with Lung Function. Epidemiology. 25(5):648-657, September 2014.
Gehring U, Gruzieva O, Agius RM, Beelen R, Custovic A, Cyrys J, Eeftens M, Flexeder C,
Fuertes E, Heinrich J, Hoffmann B, de Jongste JC, Kerkhof M, Klümper C, Korek M, Mölter A,
Schultz ES, Simpson A, Sugiri D, Svartengren M, von Berg A, Wijga AH, Pershagen G,
Brunekreef B. Air pollution exposure and lung function in children: the ESCAPE project.
Environ Health Perspect. 2013 Nov-Dec;121(11-12):1357-64. doi: 10.1289/ehp.1306770. Epub
2013 Sep 24.
Lepeule J, Litonjua AA, Coull B, Koutrakis P, Sparrow D, Vokonas PS, Schwartz J. Longterm
Effects of Traffic Particles on Lung Function Decline in the Elderly. Am J Respir Crit Care
Med. 2014 Jul 16. [Epub ahead of print]
Qiu H, Tian LW, Pun VC, Ho KF, Wong TW, Yu IT. Coarse particulate matter associated
with increased risk of emergency hospital admissions for pneumonia in Hong Kong. Thorax.
2014 Aug 27. pii: thoraxjnl-2014-205429. doi: 10.1136/ thoraxjnl-2014-205429. [Epub ahead
of print]
Jedrychowski WA, Perera FP, Maugeri U, Majewska R, Mroz E, Flak E, Camann D, Sowa
A, Jacek R. Long term effects of prenatal and postnatal airborne PAH exposures on ventilatory
lung function of non-asthmatic preadolescent children. Prospective birth cohort study in
75
Krakow. Sci Total Environ. 2014 Oct 6;502C:502-509. doi: 10.1016/ j.scitotenv.2014.09.051.
[Epub ahead of print]
Hua J, Yin Y, Peng L, Du L, Geng F, Zhu L. Acute effects of black carbon and PM2.5 on
children asthma admissions: a time-series study in a Chinese city. Sci Total Environ. 2014 May
15;481:433-8. doi: 10.1016/j.scitotenv.2014.02.070. Epub 2014 Mar 12.
Bui DS, Burgess JA, Matheson MC, Erbas B, Perret J, Morrison S, Giles GG, Hopper JL,
Thomas PS, Markos J, Abramson MJ, Walters EH, Dharmage SC. Ambient wood smoke, traffic
pollution and adult asthma prevalence and severity. Respirology. 2013 Oct;18(7):1101-7. doi:
10.1111/resp.12108.
Baccarelli AA, Zheng Y, Zhang X, Chang D, Liu L, Wolf K, Zhang Z, McCracken JP, Díaz
A, Bertazzi P, Schwartz J, Wang S, Kang CM, Koutrakis P, Hou L. Air pollution exposure and
lung function in highly exposed subjects in Beijing, China: a repeated- measure study. Part
Fibre Toxicol. 2014 Oct 2;11(1):51. [Epub ahead of print]
Young M, et al. Ambient Air Pollution Exposure and Incident Adult Asthma in a Nationwide
Cohort of U.S. Women. American Journal of Respiratory and Critical Care Medicine, Vol. 190,
No. 8 (2014), pp. 914-921. doi: 10.1164/rccm.201403-0525OC
Darrow LA, Klein M, Flanders WD, Mulholland JA, Tolbert PE, Strickland MJ. Air
Pollution and Acute Respiratory Infections Among Children 0-4 Years of Age: An 18-Year Time-
Series Study.
Am J Epidemiol. 2014 Oct 16. pii: kwu234. [Epub ahead of print]
Luttmann-Gibson H, Sarnat SE, Suh HH, Coull BA, Schwartz J, Zanobetti A, Gold DR.
Short-term effects of air pollution on oxygen saturation in a cohort of senior adults in
Steubenville, Ohio. J Occup Environ Med. 2014 Feb;56(2):149-54. doi: 10.1097/ JOM.
0000000000000089.
Lepeule J, Litonjua AA, Coull B, Koutrakis P, Sparrow D, Vokonas PS, Schwartz J. Longterm
effects of traffic particles on lung function decline in the elderly. Am J Respir Crit Care
Med. 2014 Sep 1;190(5):542-8. doi: 10.1164/rccm.201402-0350OC.
Luo B, Shi H, Wang L, Shi Y, Wang C, Yang J, Wan Y, Niu J. Rat Lung Response to PM2.5
Exposure under Different Cold Stresses. Int J Environ Res Public Health. 2014 Dec 12;11(12):
12915-12926.
Chen CH, Chan CC, Chen BY, Cheng TJ, Leon Guo Y. Effects of particulate air pollution
and ozone on lung function in non-asthmatic children. Environ Res. 2014 Dec 5;137C:40-48.
doi: 10.1016/j.envres.2014.11.021. [Epub ahead of print]
Chen Z, Salam MT, Eckel SP1, Breton CV, Gilliland FD. Chronic effects of air pollution on
respiratory health in Southern California children: findings from the Southern California
Children’s Health Study. J Thorac Dis. 2015 Jan;7(1):46-58. doi: 10.3978/j.issn.
76
2072-1439.2014.12.20.
Gehring U, Beelen R, Eeftens M, Hoek G, de Hoogh K, de Jongste JC, Keuken M,
Koppelman GH, Meliefste K, Oldenwening M, Postma DS, van Rossem L, Wang M, Smit HA,
Brunekreef B. Particulate Matter Composition and Respiratory Health: The PIAMA Birth
Cohort Study. Epidemiology. 2015 Feb 13. [Epub ahead of print]
Rice MB, Ljungman PL, Wilker EH, Dorans KS, Gold DR, Schwartz J, Koutrakis P,
Washko GR, O’Connor GT, Mittleman MA. Long-Term Exposure to Traffic Emissions and Fine
Particulate Matter and Lung Function Decline in the Framingham Heart Study. Am J Respir
Crit Care Med. 2015 Jan 15. [Epub ahead of print]
Yang L, Liu G, Lin Z, Wang Y, He H, Liu T, Kamp DW. Pro-inflammatory response and
oxidative stress induced by specific components in ambient particulate matter in human
bronchial epithelial cells.
Environ Toxicol. 2014 Dec 23. doi: 10.1002/tox.22102. [Epub ahead of print]
Gauderman WJ, et al. Association of Improved Air Quality with Lung Development in
Children. N Engl J Med 2015; 372:905-913March 5, 2015DOI: 10.1056/ NEJMoa1414123
Pope D, et al. Exposure to Household Air Pollution from Wood Combustion and
Association with Respiratory Symptoms and Lung Function in Nonsmoking Women: Results
from the RESPIRE Trial, Guatemala. Environ Health Perspect. 2015 Apr;123(4):285-92. doi:
10.1289/ehp.1408200. Epub 2014 Nov 14
Johannson KA, Balmes JR, Collard HR. Air pollution exposure: a novel environmental risk
factor for interstitial lung disease? Chest. 2015 Apr 1;147(4):1161-7. doi: 10.1378/chest.
14-1299.
Jacquemin B, et al. Ambient Air Pollution and Adult Asthma Incidence in Six European
Cohorts (ESCAPE) Environ Health Perspect; DOI:10.1289/ehp.1408206
Upadhyay A, et al. Impact of indoor air pollution from the use of solid fuels on the
incidence of life threatening respiratory illnesses in children in India. BMC Public Health.
2015; 15: 300. Published online 2015 Mar 28. doi: 10.1186/s12889-015-1631-7
Li MH, Fan LC, Mao B, Yang JW, Choi AM, Cao WJ, Xu JF. Short Term Exposure to
Ambient Fine Particulate Matter (PM2.5) Increases Hospitalizations and Mortality of Chronic
Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Chest. 2015 Jun 25.
doi: 10.1378/chest.15-0513.
Künzi L, et al., Toxicity of aged gasoline exhaust particles to normal and diseased airway
epithelia. Scientific Reports, 2015; 5: 11801 DOI: 10.1038/srep11801
Yang S, et al. Prenatal Particulate Matter/Tobacco Smoke Increases Infants’ Respiratory
Infections: COCOA Study. Allergy Asthma Immunol Res. 2015 Nov;7(6):573-82. doi: 10.4168/
aair.2015.7.6.573. Epub 2015 Jun 25.
77
Zheng XY, et al. Association between Air Pollutants and Asthma Emergency Room Visits
and Hospital Admissions in Time Series Studies: A Systematic Review and Meta-Analysis. PLoS
One. 2015 Sep 18;10(9):e0138146. doi: 10.1371/journal.pone.0138146.
César AC, Carvalho JA Jr, Nascimento LF Association between NOx exposure and deaths
caused by respiratory diseases in a medium-sized Brazilian city. Braz J Med Biol Res. 2015 Sep
pii: S0100-879X2015005054396. [Epub ahead of print]
Malig BJ, Pearson DL, Chang YB, Broadwin R, Basu R, Green RS, Ostro B. A Time-
Stratified Case-Crossover Study of Ambient Ozone Exposure and Emergency Department Visits
for Specific Respiratory Diagnoses in California (2005-2008). Environ Health Perspect. 2015
Dec 8. [Epub ahead of print]
Raanan R, Balmes JR, Harley KG, Gunier RB, Magzamen S, Bradman A, Eskenazi B.
Decreased lung function in 7-year-old children with early-life organophosphate exposure.
Thorax. 2015 Dec 3. pii: thoraxjnl-2014-206622. doi: 10.1136/thoraxjnl-2014-206622. [Epub
ahead of print]
Ware LB, et al. Long-Term Ozone Exposure Increases the Risk of Developing the Acute
Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2015 Dec 17. [Epub ahead of
print]
Schultz E, et al. Early-Life Exposure to Traffic-related Air Pollution and Lung Function
in Adolescence. American Journal of Respiratory and Critical Care Medicine, Vol. 193, No. 2
(2016), pp. 171-177.
Heinzerling AP, et al. Lung function in woodsmoke-exposed Guatemalan children
following a chimney stove intervention. Thorax. 2016 Mar 10. pii: thoraxjnl-2015-207783. doi:
10.1136/thoraxjnl-2015-207783. [Epub ahead of print]
Sbihi H, et al. Perinatal air pollution exposure and development of asthma from birth to
age 10. Euro Respir J 2016; DOI: 10.1183/13993003.00736-2015.
Berhane K, et al. Association of Changes in Air Quality With Bronchitic Symptoms in
Children in California, 1993-2012. JAMA, 2016; 315 (14): 1491 DOI: 10.1001/jama.2016.3444
Amadeo B, et al. Impact of close-proximity air pollution on lung function in
schoolchildren in the French West Indies. BMC Public Health. 2015; 15: 45. Published online
2015 Jan 31. doi: 10.1186/s12889-015-1382-5
Upadhyay AK, et al. Impact of indoor air pollution from the use of solid fuels on the
incidence of life threatening respiratory illnesses in children in India. BMC Public Health.
2015 Mar 28;15:300. doi: 10.1186/s12889-015-1631-7.
Krall JR, et al. Associations between Source-Specific Fine Particulate Matter and
Emergency Department Visits for Respiratory Disease in Four U.S. Cities. Environ Health
Perspect. 2016 Jun 17. [Epub ahead of print]
78
Shi J, Chen R, Yang C, Lin Z, Cai J, Xia Y, Wang C, Li H, Johnson N, Xu X, Zhao Z, Kan
H. Association between fine particulate matter chemical constituents and airway inflammation:
A panel study among healthy adults in China. Environ Res. 2016 Jun 21;150:264-268. doi:
10.1016/j.envres.2016.06.022. [Epub ahead of print]
Rissler J, et al. Experimental determination of deposition of diesel exhaust particles in the
human respiratory tract. Journal of Aerosol Science, 2012; 48: 18 DOI: 10.1016/j.jaerosci.
2012.01.005
Mirabelli MC, et al. Outdoor PM2.5, Ambient Air Temperature, and Asthma Symptoms in
the Past 14 Days among Adults with Active Asthma. Environ Health Perspect. 2016 Jul 6.
[Epub ahead of print]
Bharadwaj P, et al. Early Life Exposure to the Great Smog of 1952 and the Development
of Asthma. Am J Respir Crit Care Med. First published online 08 Jul 2016 as DOI: 10.1164/
rccm.201603-0451OC
Strickland M, et al. Pediatric Emergency Visits and Short-Term Changes in PM2.5
Concentrations in the U.S. State of Georgia. Environ Health Perspect; DOI:10.1289/ehp.
1509856
Lakey PS, Berkemeier T, Tong H, Arangio AM, Lucas K, Pöschl U, Shiraiwa M. Chemical
exposure-response relationship between air pollutants and reactive oxygen species in the human
respiratory tract. Sci Rep. 2016 Sep 8;6:32916. doi: 10.1038/srep32916.
Sbihi H, Koehoorn M, Tamburic L, Brauer M. Asthma Trajectories in a Population-based
Birth Cohort: Impacts of Air Pollution and Greenness. Am J Respir Crit Care Med. 2016 Sep 8.
[Epub ahead of print]
Santos UP, et al. Association between Traffic Air Pollution and Reduced Forced Vital
Capacity: A Study Using Personal Monitors for Outdoor Workers. PLoS One. 2016 Oct
6;11(10):e0163225.
Lanari M, et al. Exposure to vehicular traffic is associated to a higher risk of
hospitalization for bronchiolitis during the first year of life. Minerva Pediatr. 2016 Dec;68(6):
391-397. Epub 2015 Sep 18.
Fisher JE, Loft S, Ulrik CS, Raaschou-Nielsen O, Hertel O, Tjønneland A, Overvad K,
Nieuwenhuijsen MJ, Andersen ZJ. Physical Activity, Air Pollution and the Risk of Asthma and
Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Sep 21. [Epub
ahead of print]
Rush B, et al. Association between chronic exposure to air pollution and mortality in the
acute respiratory distress syndrome. Environ Pollut. 2017 Feb 12. pii:
S0269-7491(16)32622-7. doi: 10.1016/j.envpol.2017.02.014. [Epub ahead of print]
Prieto-Parra L, et al. Air pollution, PM2.5 composition, source factors, and respiratory
79
symptoms in asthmatic and nonasthmatic children in Santiago, Chile. Environ Int. 2017 Feb 12.
pii: S0160-4120(17)30192-7. doi: 10.1016/j.envint.2017.01.021. [Epub ahead of print]
Li XY, Hao L, Liu YH, Chen CY, Pai VJ, Kang JX. Protection against fine particleinduced
pulmonary and systemic inflammation by omega-3 polyunsaturated fatty acids. Biochim
Biophys Acta. 2017 Mar; 1861(3):577-584. PMID: 28011301.
O’ Lenick CR, et al. Ozone and childhood respiratory disease in three US cities:
evaluation of effect measure modification by neighborhood socioeconomic status using a
Bayesian hierarchical approach. Environ Health. 2017 Apr 5;16(1):36. doi: 10.1186/
s12940-017-0244-2.
Mazenq J, et al. Air pollution and children’s asthma-related emergency hospital visits in
southeastern France. Eur J Pediatr. 2017 Apr 5. doi: 10.1007/s00431-017-2900-5. [Epub
ahead of print]
Chowdhury PH, et al. Synergistic effect of carbon nuclei and polyaromatic hydrocarbons
on respiratory and immune responses. Environ Toxicol. 2017 Apr 26. doi: 10.1002/tox.22430.
[Epub ahead of print]
Liu Y, Feng GZ, Du Q, Jin XX, Du XR. Fine particulate matter aggravates allergic airway
inflammation through thymic stromal lymphopoietin activation in mice. Mol Med Rep. 2017 Jul
doi: 10.3892/mmr.2017.7089. [Epub ahead of print]
Panis L, Provost EB, Cox B, Louwies T, Laeremans M, Standaert A, Dons E, Holmstock L,
Nawrot T, De Boever P. Short-term air pollution exposure decreases lung function: a repeated
measures study in healthy adults. Environ Health. 2017 Jun 14;16(1):60. doi: 10.1186/
s12940-017-0271-z. PMID: 28615020 [PubMed – in process]
Sesé L, et al. Role of atmospheric pollution on the natural history of idiopathic pulmonary
fibrosis. Thorax. 2017 Aug 10. pii: thoraxjnl-2017-209967. doi: 10.1136/
thoraxjnl-2017-209967. [Epub ahead of print]
Deng Q, et al. Particle deposition in tracheobronchial airways of an infant, child and
adult. Sci Total Environ. 2017 Aug 27;612:339-346. doi: 10.1016/j.scitotenv.2017.08.240.
[Epub ahead of print]
Malley C, et al. Updated Global Estimates of Respiratory Mortality in Adults ≥30 Years of
Age Attributable to Long-Term Ozone Exposure. Environ Health Perspect; DOI:10.1289/
EHP1390
Doiron D, et al. Residential Air Pollution and Associations with Wheeze and Shortness of
Breath in Adults: A Combined Analysis of Cross-Sectional Data from Two Large European
Cohorts. Environ Health Perspect; DOI:10.1289/EHP1353
de Oliveira Alves N, et al. Biomass burning in the Amazon region causes DNA damage
and cell death in human lung cells. Scientific Reports, 2017; 7 (1) DOI: 10.1038/
80
s41598-017-11024-3
Bowatte G, et al. Traffic-related air pollution exposure over a 5-year period is associated
with increased risk of asthma and poor lung function in middle age. Eur Respir J. 2017 Oct
26;50(4). pii: 1602357. doi: 10.1183/13993003.02357-2016. Print 2017 Oct.
Yoda Y, et al. Acute effects of air pollutants on pulmonary function among students: a
panel study in an isolated island. Environ Health Prev Med. 2017 Apr 4;22(1):33. doi:
10.1186/s12199-017-0646-3.
Girguis MS, et al. Exposure to acute air pollution and risk of bronchiolitis and otitis media
for preterm and term infants. J Expo Sci Environ Epidemiol. 2017 Dec 21. doi: 10.1038/
s41370-017-0006-9. [Epub ahead of print]
Pirozzi CS, Jones BE, VanDerslice JA, Zhang Y, Paine R, Dean N. Short-Term Air
Pollution and Incident Pneumonia: A Case-Crossover Study. Ann Am Thorac Soc. 2017 Dec
doi: 10.1513/AnnalsATS.201706-495OC. [Epub ahead of print]
Siddharthan T, et al. Association Between Household Air Pollution Exposure and Chronic
Obstructive Pulmonary Disease Outcomes in 13 Low- and Middle-income Country Settings. Am
J Respir Crit Care Med. 2018 Jan 11. doi: 10.1164/rccm.201709-1861OC. [Epub ahead of
print]
Kim YH, et al. Mutagenicity and Lung Toxicity of Smoldering vs. Flaming Emissions
from Various Biomass Fuels: Implications for Health Effects from Wildland Fires. Environ
Health Perspect; DOI:10.1289/EHP2200
Rosa MJ, et al. Evidence establishing a link between prenatal and early-life stress and
asthma development. Curr Opin Allergy Clin Immunol. 2018 Jan 23. doi: 10.1097/ACI.
[Epub ahead of print]
Lin H, Qian ZM, Guo Y, Zheng Y, Ai S, Hang J, Wang X, Zhang L, Liu T, Guan W, Li X,
Xiao J, Zeng W, Xian H, Howard SW, Ma W, Wu F. The attributable risk of chronic obstructive
pulmonary disease due to ambient fine particulate pollution among older adults. Environ Int.
2018 Feb 5;113:143-148. doi: 10.1016/j.envint.2018.01.029. [Epub ahead of print] PMID:
29425898 [PubMed – as supplied by publisher]
Lavigne É, Bélair MA, Rodriguez Duque D, Do MT, Stieb DM, Hystad P, van Donkelaar
A, Martin RV, Crouse DL, Crighton E, Chen H, Burnett RT, Weichenthal S, Villeneuve PJ, To T,
Brook JR, Johnson M, Cakmak S, Yasseen AS 3rd, Walker M. Effect modification of perinatal
exposure to air pollution and childhood asthma incidence. Eur Respir J. 2018 Feb 1. pii:
doi: 10.1183/13993003.01884-2017.
Dubrowski A, et al. Long-Term Exposure to Ambient Air Pollution in Childhood-
Adolescence and Lung Function in Adulthood.Adv Exp Med Biol. 2018 Feb 15. doi:
10.1007/5584_2018_162. [Epub ahead of print]
81
Bai L, et al. Exposure to traffic-related air pollution and acute bronchitis in children:
season and age as modifiers. J Epidemiol Community Health. 2018 Feb 9. pii:
jech-2017-209948. doi: 10.1136/jech-2017-209948. [Epub ahead of print]
Khalili R, et al. Early-life exposure to PM2.5 and risk of acute asthma clinical encounters
among children in Massachusetts: a case-crossover analysis. Environ Health. 2018 Feb
21;17(1):20. doi: 10.1186/s12940-018-0361-6.
Mei M, et al. Early-life exposure to three size-fractionated ultrafine and fine atmospheric
particulates in Beijing exacerbates asthma development in mature mice. Part Fibre Toxicol.
2018 Mar 14;15(1):13. doi: 10.1186/s12989-018-0249-1.
Bai Y, et al. Carbon load in airway macrophages as a biomarker of exposure to
particulate air pollution; a longitudinal study of an international Panel. Part Fibre Toxicol.
2018 Mar 14;15(1):14. doi: 10.1186/s12989-018-0250-8.
Xu F, et al. Necroptosis Contributes to Urban Particulate Matter-Induced Airway
Epithelial Injury. Cell Physiol Biochem. 2018 Mar 29;46(2):699-712. doi: 10.1159/000488726.
[Epub ahead of print]
Horne BD, et al. Short-term Elevation of Fine Particulate Matter Air Pollution and Acute
Lower Respiratory Infection. Am J Respir Crit Care Med. 2018 Apr 13. doi: 10.1164/rccm.
201709-1883OC. [Epub ahead of print]
1. Conti S, et al. The association between air pollution and the incidence of idiopathic
  pulmonary fibrosis in Northern Italy. Eur Respir J. 2018 Jan 25;51(1). pii: 1700397. doi:
  10.1183/13993003.00397-2017. Print 2018 Jan.
Finke I, et al. Air pollution and airway resistance at age 8 years – the PIAMA birth cohort
study.Environ Health. 2018 Jul 17;17(1):61. doi: 10.1186/s12940-018-0407-9.
Lin MT, et al. Association of meteorological factors and air NO2 and O3 concentrations
with acute exacerbation of elderly chronic obstructive pulmonary disease. Sci Rep. 2018 Jul
5;8(1):10192. doi: 10.1038/s41598-018-28532-5.
James KA, et al. Health Services Utilization in Asthma Exacerbations and PM10 Levels in
Rural Colorado. Ann Am Thorac Soc. 2018 Jul 6. doi: 10.1513/AnnalsATS.201804-273OC.
[Epub ahead of print]
Lopes dB, et al. Pre- and postnatal exposure of mice to concentrated urban PM2.5
decreases the number of alveoli and leads to altered lung function at an early stage of life.
Environ Pollut. 2018 Jun 4;241:511-520. doi: 10.1016/j.envpol.2018.05.055. [Epub ahead of
print]
Choi H, et al. Greater susceptibility of girls to airborne Benzo[a]pyrene for obesityassociated
childhood asthma. Environ Int. 2018 Sep 17;121(Pt 1):308-316. doi: 10.1016/
j.envint.2018.08.061. [Epub ahead of print]
82
Kennedy CM, et al. Associations of mobile source air pollution during the first year of life
with childhood pneumonia, bronchiolitis, and otitis media. Environ Epidemiol. 2018 Mar;2(1).
pii: e007. doi: 10.1097/EE9.0000000000000007.
Song J, et al. Acute effects of ambient air pollution on outpatient children with respiratory
diseases in Shijiazhuang, China. BMC Pulm Med. 2018 Sep 6;18(1):150. doi: 10.1186/
s12890-018-0716-3.
Milanzi EB, et al. Air pollution exposure and lung function until age 16: the PIAMA birth
cohort study. Eur Respir J. 2018 Aug 23. pii: 1800218. doi: 10.1183/13993003.00218-2018.
[Epub ahead of print]
Patel S, et al. Associations between household air pollution and reduced lung function in
women and children in rural southern India. J Appl Toxicol. 2018 Jul 25. doi: 10.1002/jat.
[Epub ahead of print]
Beamer PI, et al. CC16 Levels into Adult Life are Associated with Nitrogen Dioxide
Exposure at Birth. Am J Respir Crit Care Med. 2019 Feb 21. doi: 10.1164/rccm.
201808-1488OC. [Epub ahead of print]
Usemann J, et al. Exposure to moderate air pollution and associations with lung function
at school-age: A birth cohort study. Environ Int. 2019 Mar 11;126:682-689. doi: 10.1016/
j.envint.2018.12.019. [Epub ahead of print]
Liu Y, et al. Short-Term Exposure to Ambient Air Pollution and Asthma Mortality. Am J
Respir Crit Care Med. 2019 Mar 15. doi: 10.1164/rccm.201810-1823OC. [Epub ahead of print]
Brigham EP, et al. Omega-3 and Omega-6 Intake Modifies Asthma Severity and Response
to Indoor Air Pollution in Children. Am J Respir Crit Care Med. 2019 Mar 29. doi: 10.1164/
rccm.201808-1474OC. [Epub ahead of print]
Rosa MJ, Perzanowski MS. Dietary Fat Intake, Particulate Matter Exposure and Asthma
Severity. Am J Respir Crit Care Med. 2019 Mar 29. doi: 10.1164/rccm.201902-0296ED. [Epub
ahead of print]

Pollution and Birth Outcomes

Air pollution causes morphologic changes in the placenta, and disrupts placental and
umbilical cord vasculature, decreasing placental blood vessels, and inhibiting blood
transfer to the fetus
83
Pregnant women exposed to more air pollution have multiple adverse pregnancy
outcomes including higher blood pressure, higher rates of pre- eclampsia, intrauterine growth retardation, premature births, premature rupture of membranes, low birth wt. syndrome, still births, gestational diabetes, and neonates with smaller head circumference.
- Intrauterine inflammation, a significant risk factor for premature birth, shows a very significant correlation with air pollution, including preconception exposure.
- Air pollution is associated with higher rates of birth defects including neural tube and cardiac birth defects.

Forbes LJ, Kapetanakis V, Rudnicka AR, Cook DG, Bush T, Stedman JR, Whincup PH,
Strachan DP, Anderson HR. Nascimento LF, Moreira DA. Are environmental pollutants risk
factors for low birth weight? Cad Saude Publica. 2009 Aug;25(8):1791-6.
van den Hooven EH, de Kluizenaar Y, Pierik FH, Hofman A, van Ratingen SW, Zandveld PY,
Mackenbach JP, Steegers EA, Miedema HM, Jaddoe VW. Air Pollution, Blood Pressure, and
the Risk of Hypertensive Complications During Pregnancy: The Generation R Study.
Hypertension. 2011 Jan 10. [Epub ahead of print]
Yorifuji T, Naruse H, Kashima S, Ohki S, Murakoshi T, Takao S, Tsuda T, Doi H. Residential
Proximity to Major Roads and Preterm Births. Epidemiology. 2010 Nov 3. [Epub ahead of
print].
Lupo, PJ, E Symanski, DK Waller, MA Canfield and LE Mitchellet. 2010. Maternal exposure
to ambient levels of benzene and neural tube defect among offspring, Texas, 1999-2004.
Environmental Health Perspectives 2011 Mar; 119(3): 397–402. Published online 2010 Oct
doi: 10.1289/ehp.1002212
Rahman, Anisur. Arsenic Exposure and Risk of Spontaneous Abortion, Stillbirth, and Infant
Mortality. Epidemiology. November 2010 – Volume 21 – Issue 6 – pp 797-804 doi: 10.1097/EDE.
0b013e3181f56a0d
Bell ML, Belanger K, Ebisu K, Gent JF, Lee HJ, Koutrakis P, Leaderer BP. Prenatal
Exposure to Fine Particulate Matter and Birth Weight: Variations by Particulate Constituents
and Sources. Epidemiology. 2010 Aug 31. [Epub ahead of print]
Suzuki, T., Oshio, S., Iwata, M., et al. In utero exposure to a low concentration of diesel
84
exhaust affects spontaneous locomotor activity and monoaminergic system in m
Veras MM, Damaceno-Rodregues N, Caldini E, Ribeiro A, et al. Particulate Urban Air
Pollution Affects the Functional Morphology of Mouse Placenta. Biology of Reproduction Sept.
1, 2008 vol. 79 no. 3 578-584.
Hansen C, Barnett A, Prichard G. The Effect of Ambient Air Pollution during Early
Pregnancy on Fetal Ultrasound Measurements during Mid-Pregnancy. Environ Health Persp
Vol. 116, Number 3, March 2008
Wu J, Ren C, Delfino RJ, Chung J, Wilhelm M, Ritz B 2009. Association between Local
Traffic-Generated Air Pollution and Preeclampsia and Preterm Delivery in the South Coast Air
Basin of California. Environ Health Perspect 117:1773-1779. doi: 10.1289/ehp.0800334
Ritz B, Yu F, Fruin S, Chapa G, Shaw G, Harris J. Ambient Air Pollution and Risk of Birth
Defects in Southern California. Am. J. Epidemiol. (2002) 155(1): 17-25 doi: 10.1093/aje/
155.1.17
Vrijheid M, Martinez D, Manzanares S, Dadvand P, Schembari A, Rankin J, Nieuwenhuijsen
M. Environ Health Perspect. 2010 Dec 3. [Epub ahead of print] Ambient Air Pollution and Risk
of Congenital Anomalies: A Systematic Review and Meta-Analysis.
Dadvand P, Rankin J, Rushton S, Pless-Mulloli T. Ambient air pollution and congenital
heart diseas
Estarlich M, et al. Residential exposure to outdoor air pollution during pregnancy and
anthropometric measures at birth in a multicenter cohort in spain. Environmental Health
Perspectives, in press. Posted online March 23, 2011. doi: 10.1289/ehp.1002918
Hwang BF, Lee YL, Jaakkola JJ. Air Pollution and Stillbirth: A Population-Based Case-
Control Study in Taiwan. Environ Health Perspect. 2011 Mar 28. [Epub ahead of print]
Lee PC, Talbott EO, Roberts JM, Catov JM, Sharma RK, Ritz B. Particulate Air Pollution
Exp
Darrow LA, Klein M, Strickland MJ, Mulholland JA, Tolbert PE 2011. Ambient Air
Pollution and Birth Weight in Full-Term Infants in Atlanta, 1994–2004. Environ Health
Perspect 119:731-737. doi:10.
Salihu HM, August EM, Mbah AK, Alio AP, de Cuba R 2nd, Jaward FM, Berry EL.
Effectiveness of a Federal Healthy Start Program in Reducing the Impact of Particulate Air
Pollutants on Feto-Infant Morbidity Outcomes. Matern Child Health J. 2011 Jul 17. [Epub
ahead of print]
Wilhelm M, Ghosh JK, Su J, Cockburn M, Jerrett M, Ritz B. Traffic-Related Air Toxics and
Term Low Birth Weight in Los Angeles County, California. Environ Health Perspect. 2011 Aug
[Epub ahead of print]
Jedrychowski W1, Perera F, Mrozek-Budzyn D, Mroz E, Flak E, Spengler JD, Edwards S,
85
Jacek R, Kaim I, Skolicki Z. Gender differences in fetal growth of newborns exposed prenatally
to airborne fine particulate matter. Environ Res. 2009 May;109(4):447-56. doi: 10.1016/
j.envres.2009.01.009. Epub 2009 Mar 3.
ChunMei L, et al. Effects of Exposure to Nanoparticle-rich Diesel Exhaust on Pregnancy in
Rats. J Reprod Dev. 2013 Apr; 59(2): 145–150. Published online 2012 Dec 20. doi: 10.1262/
jrd.2012-145
Pereira G, Nassar N, Cook A, Bow C. Traffic emissions are associated with reduced fetal
growth in areas of Perth, Western Australia: an application of the AusRoads dispersion model.
Australian and New Zealand Journal of Public Health. Volume 35, Issue 5, pages 451–458,
October 2011
Wilhelm M, Ghosh JK, Su J, Cockburn M, Jerrett M, Ritz B. Traffic-related air toxics and
preterm birth: a population-based case-control study in Los Angeles County, California.
Environmental Health 2011, 10:89 doi:10.1186/1476-069X-10-89
Ren A, Qiu X, Jin L, Ma J, Li Z, et al. Association of selected persistent organic pollutants in
the placenta with the risk of neural tube defects. PNAS 2011 : 1105209108v1-201105209.
van den Hooven EH, Pierik FH, de Kluizenaar Y, Willemsen SP, Hofman A, van Ratingen
SW, et al. 2011. Air Pollution Exposure During Pregnancy, Ultrasound Measures of Fetal
Growth, and Adverse Birth Outcomes: A Prospective Cohort Study. Environ Health Perspect :-.
http://dx.doi.org/10.1289/ehp.1003316
Yorifuji T, Naruse H, Kashima S, Murakoshi T, Tsuda T, Doi H, Kawachi I. Residential
proximity to major roads and placenta/birth weight ratio. Sci Total Environ. 2011 Dec 3. [Epub
ahead of print]
Olsson D, Ekström M, Forsberg B. Temporal Variation in Air Pollution Concentrations and
Preterm Birth—A Population Based Epidemiological Study. Int. J. Environ. Res. Public Health
2012, 9, 272-285; doi:10.3390/ijerph9010272
Le HQ, Batterman SA, Wirth JJ, Wahl RL, Hoggatt KJ, Sadeghnejad A, Hultin ML, Depa M.
Air pollutant exposure and preterm and term small-for-gestational-age births in Detroit,
Michigan: Long-term trends and associations. Environ Int. 2012 Feb 6. [Epub ahead of print]
Jedrychowski WA, Perera FP, Maugeri U, Spengler J, Mroz E, Flak E, Stigter L, Majewska
R, Kaim I, Sowa A, Jacek R. Prohypertensive Effect of Gestational Personal Exposure to Fine
Particulate Matter. Prospective Cohort Study in Non-smoking and Non-obese Pregnant Women.
Cardiovasc Toxicol. 2012 Feb 11. [Epub ahead of print]
Olsson D, Ekström M, Forsberg B. Int J Environ Res Public Health. 2012 Jan;9(1): 272-85.
Epub 2012 Jan 18. Temporal variation in air pollution concentrations and preterm birth-a
population based epidemiological study.
Ghosh JK, Wilhelm M, Su J, Goldberg D, Cockburn M, Jerrett M, Ritz B. Assessing the
86
Influence of Traffic-related Air Pollution on Risk of Term Low Birth Weight on the Basis of
Land-Use-based Regression Models and Measures of Air Toxics. Am J Epidemiol. 2012 May 13.
[Epub ahead of print]
Kloog I, Melly SJ, Ridgway WL, Coull BA, Schwartz J. Using New Satellite Based Exposure
Methods to Study the Association Between Pregnancy PM 2.5 Exposure, Premature Birth And
Birth Weight In MassachusettUsing new satellite based exposure methods to study the
association between pregnancy pm2.5 exposure, premature birth and birth weight in
Massachusettss. Environ Health. 2012 Jun 18;11(1):40. [Epub ahead of print]
Faiz AS, Rhoads GG, Demissie K, Kruse L, Lin Y, Rich DQ. Ambient Air Pollution and the
Risk of Stillbirth. Am J Epidemiol. 2012 Jul 18. [Epub ahead of print] PMID: 22811493
Miranda ML, Edwards SE, Chang HH, Auten RL. Proximity to roadways and pregnancy
outcomes. J Expo Sci Environ Epidemiol. 2012 Jul 18. doi: 10.1038/jes. 2
Lee PC, Talbott EO, Roberts JM, Catov JM, Bilonick RA, Stone RA, Sharma RK, Ritz B.
Ambient air pollution exposure and blood pressure changes during pregnancy. Environ Res.
2012 Jul 24. [Epub ahead of print]
Proietti E, Röösli M, Frey U, Latzin P. Air Pollution During Pregnancy and Neonatal
Outcome: A Review. J Aerosol Med Pulm Drug Deliv. 2012 Aug 2. [Epub ahead of print]
Pereira G, Cook AG, Haggar F, Bower C, Nassar N. Locally derived traffic-related air
pollution and fetal growth restriction: a retrospective cohort study.Occup Environ Med. 2012
Jul 31. [Epub ahea
Faiz A, Rhoads G, Demissie K, Kruse L, Lin Y, Rich D. Ambient Air Pollution and the Risk
of Stillbirth. Am. J. Epidemiol. (2012) 176(4): 308-316 doi:10.1093/aje/kws029
Pereira G, Haggar F, Shand AW, Bower C, Cook A, Nassar N. Association between preeclampsia
and locally derived traffic-related air pollution: a retrospective cohort study. J
Epidemiol Community Health. 2012 Aug 9. [Epub ahead of print]
van den Hooven EH, Pierik FH, de Kluizenaar Y, Hofman A, van Ratingen SW, Zandveld
PY, et al. 2012. Air Pollution Exposure and Markers of Placental Growth and Function: The
Generation R Study. Environ Health Perspect :-. http://dx.doi.org/10.1289/ ehp.1204918
Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight
and exposure to airborne fine particulate potassium and titanium during gestation. Environ Res.
2012 Jun 15. [Epub ahead of print]
Shah PS, Balkhair T. Air pollution and birth outcomes: a systematic review. Knowledge
Synthesis Group on Determinants of Preterm/LBW births. Collaborators: Environ Int. 2011
Feb;37(2):498-516. Epub 2010 Nov 26.
Shah PS, Ohlsson A, Shah V, Murphy KE, McDonald SD, Hutton E, Newburn-Cook C, Frick
C, Scott F, Allen V, Beyene J, Stieb DM, Chen L, Eshoul M, Judek S. Ambient air pollution,
87
birth weight and preterm birth: A systematic review and meta-analysis. Environ Res. 2012 Jun
[Epub ahead of print].
Parker JD, Rich DQ, Glinianaia SV, Leem JH, Wartenberg D, Bell ML, Bonzini M, Brauer
M, Darrow L, Gehring U, Gouveia N, Grillo P, Ha E, van den Hooven EH, Jalaludin B, Jesdale
BM, Lepeule J, Morello-Frosch R, Morgan GG, Slama R, Pierik FH, Pesatori AC,
Sathyanarayana S, Seo J, Strickland M, Tamburic L, Woodruff TJ. The International
Collaboration on Air Pollution and Pregnancy Outcomes: initial results. Environ Health
Perspect. 2011 Jul;119(7):1023-8. Epub 2011 Feb 9.
Chang HH, Reich BJ, Miranda ML. Time-to-event analysis of fine particle air pollution and
preterm birth: results from North Carolina, 2001-2005. Am J Epidemiol. 2012 Jan 15;175(2):
91-8. Epub 2011 Dec 13.
Kessler R 2012. Followup in Southern California: Decreased Birth Weight following
Prenatal Wildfire Smoke Exposure. Environ Health Perspect 120:a362-a362. http:// dx.doi.org/
10.1289/ehp.120-a362b
Kloog, I, SJ Melly, WL Ridgway, BA Coull and J Schwartz. 2012. Using new satellite based
exposure methods to study the association between pregnancy pm2.5 exposure, premature birth
and birth weight in Massachusetts. Environmental Health http:// dx.doi.org/
10.1186/1476-069X-11-40.
Padula AM, Mortimer K, Hubbard A, Lurmann F, Jerrett M, Tager IB. Exposure to Trafficrelated
Air Pollution During Pregnancy and Term Low Birth Weight: Estimation of Causal
Associations in a Semiparametric Model. Am J Epidemiol. 2012 Oct 7. [Epub ahead of print]
Backes CH, Nelin T, Gorr MW, Wold LE. Early Life Exposure to Air Pollution: How Bad Is
It? Toxicol Lett. 2012 Nov 16. pii: S0378-4274(12)01380-X. doi: 10.1016/j.toxlet. 2012.11.007.
[Epub ahead of print]
Geer LA, Weedon J, Bell ML. Ambient air pollution and term birth weight in Texas from
1998 to 2004. J Air Waste Manag Assoc. 2012 Nov;62(11):1285-95.
Nieuwenhuijsen MJ, Dadvand P, Grellier J, Martinez D, Vrijheid M. Environmental risk
factors of pregnancy outcomes: a summary of recent meta-analyses of epidemiological studies.
Environ Health. 2013 Jan 15;12(1):6. [Epub ahead of print]
Olsson D, Forsberg M. Air pollution exposure in early pregnancy and adverse pregnancy
outcomes: a register-based cohort study. BMJ Open, 2013; 3 (2): e001955 DOI: 10.1136/
bmjopen-2012-001955
Dadvand P, Parker J, Bell ML, Bonzini M, Brauer M, Darrow L, Gehring U, Glinianaia SV,
Gouveia N, Ha EH, Leem JH, van den Hooven EH, Jalaludin B, Jesdale BM, Lepeule J,
Morello-Frosch R, Morgan GG, Pesatori AC, Pierik FH, Pless-Mulloli T, Rich DQ,
Sathyanarayana S, Seo J, Slama R, Strickland M, Tamburic L, Wartenberg D, Nieuwenhuijsen
88
MJ, Woodruff TJ. Maternal Exposure to Particulate Air Pollution and Term Birth Weight: A
Multi-Country Evaluation of Effect and Heterogeneity. Environ Health Perspect. 2012 Feb 6.
[Epub ahead of print]
Warren JL, Fuentes M, Herring AH, Langlois PH. ISRN Obstet Gynecol.
2013;2013:387452. doi: 10.1155/2013/387452. Epub 2013 Jan 30. Air pollution metric analysis
while determining susceptible periods of pregnancy for low birth weight.
Padula A, Tager I, Carmichael S, Hammond S, Lurmann F, Shaw G. The Association of
Ambient Air Pollution and Traffic Exposures With Selected Congenital Anomalies in the San
Joaquin Valley of California. Am. J. Epidemiol. (2013) doi: 10.1093/aje/kws367 First published
online: March 28, 2013
Yorifuji T, Naruse H, Kashima S, Takao S, Murakoshi T, Doi H, Kawachi I. Residential
proximity to major roads and adverse birth outcomes: a hospital-based study. Environ Health.
2013 Apr 18;12(1):34. [Epub ahead of print].
Mainolfi MB, Salihu HM, Wilson RE, Mbah AK. Low-Level Exposure to Air Pollution and
Risk of Adverse Birth Outcomes in Hillsborough County, Florida. J Occup Environ Med. 2013
Apr 24. [Epub ahead of print]
Faiz AS, Rhoads GG, Demissie K, Lin Y, Kruse L, Rich DQ. Does Ambient Air Pollution
Trigger Stillbirth? Epidemiology. 2013 May 14. [Epub ahead of print]
Dadvand P, Sunyer J, Basagaña X, Ballester F, Lertxundi A, Fernández-Somoano A,
Estarlich M, García-Esteban R, Mendez MA, Nieuwenhuijsen NJ. 2012 Surrounding greenness
and pregnancy outcomes in four Spanish birth cohorts. Environmental Health Perspectives
http://dx.doi.org/10.1289/ehp.1205244.
Xu X, Hu H, Ha S, Roth J. Ambient air pollution and hypertensive disorder of pregnancy. J
Epidemiol Community Health. 2013 Sep 10. doi: 10.1136/ jech-2013-202902. [Epub ahead of
print]
Dadvand P, Figueras F, Basagaña X, Beelen R, Martinez D, Cirach M, Schembari A, Hoek
G, Brunekreef B, Nieuwenhuijsen MJ. Ambient Air Pollution and Preeclampsia: A
Spatiotemporal Analysis. Environ Health Perspect. 2013 Sep 10. [Epub ahead of print]
Pedersen M, et al. Ambient air pollution and low birthweight: a European cohort study
(ESCAPE) The Lancet Respiratory Medicine, Early Online Publication, 15 October 2013 doi:
10.1016/S2213-2600(13)70192-9
Candela S, Ranzi A, Bonvicini L, Baldacchini F, Marzaroli P, Evangelista A, Luberto F,
Carretta E, Angelini P, Sterrantino AF, Broccoli S, Cordioli M, Ancona C, Forastiere F. Air
pollution from incinerators and reproductive outcomes: a multisite study. Epidemiology. 2013
Nov;24(6):863-70. doi: 10.1097/EDE.0b013e3182a712f1.
Savtiz D, et al. Ambient Fine Particulate Matter, Nitrogen Dioxide, and Term Birth Weight
89
in New York, New York Am. J. Epidemiol. (2013) doi: 10.1093/aje/kwt268 First published
online: November 10, 2013
Wylie BJ, Coull BA, Hamer DH, Singh MP, Jack D, Yeboah-Antwi K, Sabin L, Singh N,
Macleod WB. Impact of biomass fuels on pregnancy outcomes in central East India. Environ
Health. 2014 Jan 9;13(1):1. [Epub ahead of print]
Gianicolo EA1, Mangia C2, Cervino M3, Bruni A4, Andreassi MG5, Latini G6. Congenital
anomalies among live births in a high environmental risk area-A case-control study in Brindisi
(southern Italy). Environ Res. 2014 Jan;128:9-14. doi: 10.1016/ j.envres.2013.11.002. Epub
2013 Dec 17.
McKenzie L, et al. Birth Outcomes and Maternal Residential Proximity to Natural Gas
Development in Rural Colorado Environ Health Perspect; DOI:10.1289/ehp. 1306722
Gray S, Edwards S, Schultz B, and Miranda M. Assessing the impact of race, social factors
and air pollution on birth outcomes: a population-based study. Environmental Health 2014,
13:4 doi:10.1186/1476-069X-13-4
Fleisch A, et al. Air Pollution Exposure and Abnormal Glucose Tolerance during
Pregnancy: The Project Viva Cohort. Environ Health Perspect; DOI:10.1289/ehp. 1307065
Xu X, Hu H, Ha S, Roth J, Air pollution Ambient air pollution and hypertensive disorder of
pregnancy. J Epidemiol Community Health 2014;68:13-20 doi:10.1136/ jech-2013-202902
Enkhmaa D, Warburton N, Javzandulam B, Uyanga J, Khishigsuren Y, Lodoysamba S,
Enkhtur S, Warburton D. Seasonal ambient air pollution correlates strongly with spontaneous
abortion in Mongolia. BMC Pregnancy Childbirth. 2014 Apr 23;14(1):146. [Epub ahead of
print]
Stingone J. Maternal Exposure to Criteria Air Pollutants and Congenital Heart Defects in
Offspring: Results from the National Birth Defects Prevention Study. Environ Health Perspect;
DOI:10.1289/ehp.1307289
Hannam K, McNamee R, Baker P, Sibley C, Agius R. Air pollution exposure and adverse
pregnancy outcomes in a large UK birth cohort: use of a novel spatio-temporal modelling
technique. Scand J Work Environ Health. 2014 Mar 19. pii: 3423. doi: 10.5271/sjweh.3423.
[Epub ahead of print]
Pedersen M, Stayner L, Slama R, Sørensen M, Figueras F, Nieuwenhuijsen MJ, Raaschou-
Nielsen O, Dadvand P. Ambient Air Pollution and Pregnancy-Induced Hypertensive Disorders:
A Systematic Review and Meta-Analysis. Hypertension. 2014 Jun 16. pii:
HYPERTENSIONAHA.114.03545. [Epub ahead of print]
Dadvand P, Figueras F, Basagaña X, Beelen R, Martinez D, Cirach M, Schembari A, Hoek
G, Brunekreef B, Nieuwenhuijsen MJ. Ambient air pollution and preeclampsia: a
spatiotemporal analysis. Environ Health Perspect. 2013 Nov-Dec;121(11-12): 1365-71. doi:
90
10.1289/ehp.1206430. Ep
Hyder A, Lee HJ, Ebisu K, Koutrakis P, Belanger K, Bell ML. PM2.5 exposure and birth
outcomes: use of satellite- and monitor-based data. Epidemiology. 2014 Jan; 25(1):58-67. doi:
10.1097/EDE.0000000000000027.
Stingone J. et al. Maternal Exposure to Criteria Air Pollutants and Congenital Heart
Defects in Offspring: Results from the National Birth Defects Prevention Study. Environ Health
Perspect; DOI:10.1289/ehp.1307289
Zhu X, Liu Y, Chen Y, Yao C, Che Z, Cao J. Maternal exposure to fine particulate matter
(PM2.5) and pregnancy outcomes: a meta-analysis. Environ Sci Pollut Res Int. 2014 Aug 28.
[Epub ahead of print]
Rappazzo K, et al. Exposure to Fine Particulate Matter during Pregnancy and Risk of
Preterm Birth among Women in New Jersey, Ohio, and Pennsylvania, 2000–2005. Environ
Health Perspect; DOI:10.1289/ehp.1307456
Holstius DM, Reid CE, Jesdale BM, Morello-Frosch R. Birth weight following pregnancy
during the 2003 Southern California wildfires. Environ Health Perspect. 2012 Sep;120(9):
1340-5. doi: 10.1289/ehp.1104515. Epub 2012 May 29.
Farhi A, Boyko V, Almagor J, Benenson I, Segre E, Rudich Y, Stern E, Lerner-Geva L. The
possible association between exposure to air pollution and the risk for congenital
malformations. Environ Res. 2014 Sep 29;135C:173-180. doi: 10.1016/ j.envres.2014.08.024.
[Epub ahead of print]
Kahn L. et al. Blood Lead Concentration and Thyroid Function during Pregnancy: Results
from the Yugoslavia Prospective Study of Environmental Lead Exposure. Environ Health
Perspect; DOI:10.1289/ehp.1307669
Ibrahimou B, Salihu HM, Aliyu MH, Anozie C. Risk of Preeclampsia From Exposure to
Particulate Matter (PM2.5) Speciation Chemicals During Pregnancy. J Occup Environ Med.
2014 Dec;56(12):1228-1234.
Porter TR, Kent ST, Su W, Beck HM, Gohlke JM. Spatiotemporal association between birth
outcomes and coke production and steel making facilities in Alabama, USA: a cross-sectional
study. Environ Health. 2014 Oct 23;13(1):85. [Epub ahead of print]
Valentino S, et al. 120 maternal exposure to diesel engine exhaust during pregnancy affects
early embryo development in a rabbit model. Reprod Fertil Dev. 2014 Dec;27(1):152. doi:
10.1071/RDv27n1Ab120.
Yorifuji T, Naruse H, Kashima S, Murakoshi T, Doi H. Residential proximity to major roads
and obstetrical complications. Sci Total Environ. 2014 Dec 2;508C:188-192. doi: 10.1016/
j.scitotenv.2014.11.077. [Epub ahead of print]
Fleisch AF, Rifas-Shiman SL, Koutrakis P, Schwartz JD, Kloog I, Melly S, Coull BA,
91
Zanobetti A, Gillman MW, Gold DR, Oken E. Prenatal Exposure to Traffic Pollution:
Associations with Reduced Fetal Growth and Rapid Infant Weight Gain. Epidemiology. 2015
Jan;26(1):43-50.
Liang Z, Wu L, Fan L, Zhao Q. Ambient air pollution and birth defects in Haikou city,
Hainan province. BMC Pediatr. 2014 Nov 22;14(1):283. [Epub ahead of print]
Nagiah S, Phulukdaree A, Naidoo D, Ramcharan K, Naidoo R, Moodley D, Chuturgoon A.
Oxidative stress and air pollution exposure during pregnancy: A molecular assessment. Hum
Exp Toxicol. 2014 Nov 17. pii: 0960327114559992. [Epub ahead of print]
Salam M, et al. “Birth Outcomes and Prenatal Exposure to Ozone, Carbon Monoxide and
Particulate Matter: Results from the Children’s Health Study, Environmental Health
Perspectives. Vol. 113, No. 11, November 2005, pp. 1638-1644.
Hyunok Choi H, et al. Fetal Window of Vulnerability to Airborne Polycyclic Aromatic
Hydrocarbons on Proportional Intrauterine Growth Restriction. PLoS One. 2012; 7(4): e35464.
Published online Apr 24, 2012. doi: 10.1371/journal.pone.0035464
Zhao N, et al. Ambient air pollutant PM10 and risk of preterm birth in Lanzhou, China.
Environ Int. 2014 Dec 29;76C:71-77. doi: 10.1016/j.envint.2014.12.009. [Epub ahead of print]
Dadvand P, et al. Air Pollution and Preterm Premature Rupture of Membranes: A
Spatiotemporal Analysis. Am J Epidemiol January 15, 2014 179 (2) 200-207
Lin YT, Jung CR, Lee YL, Hwang BF. Associations Between Ozone and Preterm Birth in
Women Who Develop Gestational Diabetes. Am J Epidemiol. 2015 Feb 3. pii: kwu264. [Epub
ahead of print]
Hu H, Ha S, Henderson BH, Warner TD, Roth J, Kan H, Xu X. Association of Atmospheric
Particulate Matter and Ozone with Gestational Diabetes Mellitus. Environ Health Perspect.
2015 Mar 20. [Epub ahead of print]
DeFranco E, et al. Air Pollution and Stillbirth Risk: Exposure to Airborne Particulate
Matter during Pregnancy Is Associated with Fetal Death. PLoS One. 2015 Mar
20;10(3):e0120594. doi: 10.
Rappazzo KM, Daniels JL, Messer LC, Poole C, Lobdell DT. Exposure to Elemental
Carbon, Organic Carbon, Nitrate, and Sulfate Fractions of Fine Particulate Matter and Risk of
Preterm Birth in New Jersey, Ohio, and Pennsylvania (2000-2005). Environ Health Perspect.
2015 Apr 24. [Epub ahead of print]
Rich D, et al. Differences in Birth Weight Associated with the 2008 Beijing Olympic Air
Pollution Reduction: Results from a Natural Experiment. Environ Health Perspect; DOI:
10.1289/ehp.1408795
Schembari A, de Hoogh K, Pedersen M, Dadvand P, Martinez D, Hoek G, Petherick ES,
Wright J, Nieuwenhuijsen MJ. Ambient Air Pollution and Newborn Size and Adiposity at Birth:
92
Differences by Maternal Ethnicity (the Born in Bradford Study Cohort). Environ Health
Perspect. 2015 May 15. [Epub ahead of print]Environ Health Perspect. 2015 May 15.
Pedersen M, et al. Elemental Constituents of Particulate Matter and Newborn’s Size in
Eight European Cohorts. Environ Health Perspect. 2015 Jun 5. [Epub ahead of print]
Hao Y, et al. Geographic Variation in the Association between Ambient Fine Particulate
Matter (PM2.5) and Term Low Birth Weight in the United States. Environ Health Perspect;
DOI:10.1289/ehp.1408798
Iñiguez C, Esplugues A, Sunyer J, Basterrechea M, Fernández-Somoano A, Costa O,
Estarlich M, Aguilera I, Lertxundi A, Tardón A, Guxens M, Murcia M, Lopez-Espinosa MJ,
Ballester F. Prenatal Exposure to NO2 and Ultrasound Measures of Fetal Growth in the
Spanish INMA Cohort. Environ Health Perspect. 2015 Jun 26. [Epub ahead of print]
Sun X, et al. The association between fine particulate matter exposure during pregnancy
and preterm birth: a meta-analysis. BMC Pregnancy Childbirth. 2015 Nov 18;15(1):300.
Zhu X, et al. Maternal exposure to fine particulate matter (PM2.5) and pregnancy
outcomes: a meta-analysis. Environ Sci Pollut Res Int. 2015 Mar;22(5):3383-96. doi: 10.1007/
s11356-014-3458-7. Epub 2014 Aug 28.
Kassotis C, et al. Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and
Adverse Health Outcomes After Prenatal Exposure in Male Mice. Environ Health Perspect;
DOI:10.1289/ehp.1409651
Hao H, et al. Air Pollution and Preterm Birth in the U.S. State of Georgia (2002–2006):
Associations with Concentrations of 11 Ambient Air Pollutants Estimated by Combining
Community Multiscale Air Quality Model (CMAQ) Simulations with Stationary Monitor
Measurements. Environ Health Perspect; DOI:10.1289/ehp.1409651
Casey JA, Savitz DA, Rasmussen SG, Ogburn EL, Pollak J, Mercer DG, Schwartz BS.
Unconventional Natural Gas Development and Birth Outcomes in Pennsylvania, USA.
Epidemiology. 2015 Sep 30. [Epub ahead of print]
Liu C, et al. Different exposure levels of fine particulate matter and preterm birth: a metaanalysis
based on cohort studies. Environ Sci Pollut Res Int. 2017 Jun 15. doi: 10.1007/
s11356-017-9363-0. [Epub ahead of print]
Poirier A, Dodds L, Dummer T, Rainham D, Maguire B, Johnson M. Maternal Exposure to
Air Pollution and Adverse Birth Outcomes in Halifax, Nova Scotia. J Occup Environ Med. 2015
Dec;57(12):1291-8. doi: 10.1097/JOM.0000000000000604.
Arroyoa V, et al. Short term effect of air pollution, noise and heat waves on preterm births
in Madrid (Spain). Environmental Research. Volume 145, February 2016, Pages 162–168.
Girguisa M, et al. Maternal exposure to traffic-related air pollution and birth defects in
Massachusetts. Environmental Research. Volume 146, April 2016, Pages 1–9
93
Poursafa P, Baradaran-Mahdavi S, Moradi B, Haghjooy Javanmard S, Tajadini M,
Mehrabian F, Kelishadi R. The relationship of exposure to air pollutants in pregnancy with
surrogate markers of endothelial dysfunction in umbilical cord. Environ Res. 2016 Jan
4;146:154-160. doi: 10.1016/j.envres.2015.12.018. [Epub ahead of print]
Sun X, Luo X, Zhao C, Zhang B, Tao J, Yang Z, Ma W, Liu T. The associations between
birth weight and exposure to fine particulate matter (PM_2.5) and its chemical
constituents during pregnancy: A meta-analysis. Environ Pollut. 2015 Dec 28;211:38-47. doi:
10.1016/j.envpol.2015.12.022. [Epub ahead of print]
DeFranco E, et al. Exposure to airborne particulate matter during pregnancy is associated
with preterm birth: a population-based cohort study. Environ Health. 2016 Jan 15;15(1):6. doi:
10.1186/s12940-016-0094-3.
Stieb D, et al. Associations of Pregnancy Outcomes and PM2.5 in a National Canadian
Study. Environ Health Perspect; DOI:10.1289/ehp.1408995
Yongping H, et al. Geographic Variation in the Association between Ambient Fine
Particulate Matter (PM2.5) and Term Low Birth Weight in the United States. Environ Health
Perspect; DOI:10.1289/ehp.1408798
Lamichhane DK, Leem JH, Lee JY1, Kim HC. A meta-analysis of exposure to particulate
matter and adverse birth outcomes. Environ Health Toxicol. 2015 Nov 3;30:e2015011. doi:
10.5620/eht.e2015011. eCollection 2015.
Rich D, et al. Differences in Birth Weight Associated with the 2008 Beijing Olympic Air
Pollution Reduction: Results from a Natural Experiment. Environ Health Perspect; DOI:
10.1289/ehp.1408795
Laurent O, et al. A Statewide Nested Case-Control Study of Preterm Birth and Air
Pollution by Source and Composition: California, 2001-2008. Environ Health Perspect. 2016
Feb 19. [Epub ahead of print]
Coker E, et al. Multi-pollutant exposure profiles associated with term low birth weight in
Los Angeles County. Environ Int. 2016 Feb 15;91:1-13. doi: 10.1016/j.envint.2016.02.011.
[Epub ahead of print]
Chen LY, et al. Incense Burning during Pregnancy and Birth Weight and Head
Circumference among Term Births: The Taiwan Birth Cohort Study. Environ Health Perspect.
2016 Mar 11. [Epub ahead of print]
Erickson AC, et al. The reduction of birth weight by fine particulate matter and its
modification by maternal and neighbourhood-level factors: a multilevel analysis in British
Columbia, Canada. Environ Health. 2016 Apr 14;15(1):51. doi: 10.1186/s12940-016-0133-0.
Carvalho MA, et al. Associations of maternal personal exposure to air pollution on fetal
weight and fetoplacental Doppler: a prospective cohort study. Reprod Toxicol. 2016 Apr 18. pii:
94
S0890-6238(16)30063-6. doi: 10.1016/j.reprotox.2016.04.013. [Epub ahead of print
Nachman RM, et al. Intrauterine Inflammation and Maternal Exposure to Ambient PM2.5
during Preconception and Specific Periods of Pregnancy: The Boston Birth Cohort. Environ
Health Perspect. 2016 Apr 27. [Epub ahead of print]
Li S, Guo Y, Williams G. Acute Impact of Hourly Ambient Air Pollution on Preterm Birth.
Environ Health Perspect. 2016 Apr 29. [Epub ahead of print]
Jiang M, et al. A nested case-control study of prenatal vanadium exposure and low
birthweight. Hum Reprod. 2016 Jul 4. pii: dew176. [Epub ahead of print]
Rahman A, Kumarathasan P, Gomes J. Infant and mother related outcomes from exposure
to metals with endocrine disrupting properties during pregnancy. Sci Total Environ. 2016 Jul 1.
pii: S0048-9697(16)31309-2. doi: 10.1016/j.scitotenv.2016.06.134. [Epub ahead of print]
Hettfleisch K, et al. Short-Term Exposure to Urban Air Pollution and Influences on
Placental Vascularization Indexes. Environ Health Perspect. 2016 Jul 6. [Epub ahead of print]
Clemente DBP, et al. Prenatal ambient air pollution, placental mitochondrial content, and
birth weight in the INMA (Spain) and ENVIRONAGE (Belgium) birth cohorts. Environ Health
Perspect 124(5):659–665 (2016), doi: 10.1289/ehp.1408981.
Siddika N, Balogun HA, Amegah AK, Jaakkola JJ. Prenatal ambient air pollution exposure
and the risk of stillbirth: systematic review and meta-analysis of the empirical evidence. Occup
Environ Med. 2016 May 24. pii: oemed-2015-103086. doi: 10.1136/oemed-2015-103086. [Epub
ahead of print] Review.
Wylie B, et al. Placental Pathology Associated with Household Air Pollution in a Cohort of
Pregnant Women from Dares Salaam, Tanzania. Environ Health Perspect; DOI:10.1289/
EHP256
Laurent O, et al. A Statewide Nested Case–Control Study of Preterm Birth and Air
Pollution by Source and Composition: California, 2001–2008. Environ Health Perspect; DOI:
10.1289/ehp.1510133
Casey J, et al. Unconventional Natural Gas Development and Birth Outcomes in
Pennsylvania, USA. Epidemiology. March 2016 – Volume 27 – Issue 2 – p 163–172
Liu Y, et al. Effect of Fine Particulate Matter (PM2.5) on Rat Placenta Pathology and
Perinatal Outcomes. Med Sci Monit. 2016 Sep 15;22:3274-80.
Li S, et al. Acute Impact of Hourly Ambient Air Pollution on Preterm Birth. Environ Health
Perspect; DOI:10.1289/EHP200
Díaz J, Arroyo V, Ortiz C, Carmona R, Linares C. Effect of Environmental Factors on Low
Weight in Non-Premature Births: A Time Series Analysis. PLoS One. 2016 Oct
27;11(10):e0164741
Saenen ND, et al. Lower Placental Leptin Promoter Methylation in Association with Fine
95
Particulate Matter Air Pollution during Pregnancy and Placental Nitrosative Stress at Birth in
the ENVIRONAGE Cohort. Environ Health Perspect; DOI:10.1289/EHP38
Avalos LA, Chen H, Li DK, Basu R. The impact of high apparent temperature on
spontaneous preterm delivery: a case-crossover study. Environmental Health. 2017 Feb
1;16(1):5. doi: 10.1186/s12940-017-0209-5.
Jedrychowski WA, Majewska R, Spengler JD, Camann D, Roen EL, Perera FP. Prenatal
exposure to fine particles and polycyclic aromatic hydrocarbons and birth outcomes: a twopollutant
approach. Int Arch Occup Environ Health. 2017 Feb 7. doi: 10.1007/
s00420-016-1192-9. [Epub ahead of print]
Christopher S. Malley, Johan C.I. Kuylenstierna, Harry W. Vallack, Daven K. Henze,
Hannah Blencowe, Mike R. Ashmore. Preterm birth associated with maternal fine particulate
matter exposure: A global, regional and national assessment. Environment International, 2017;
DOI: 10.1016/j.envint.2017.01.023
Zhu Y, et al. Ambient air pollution and risk of gestational hypertension. Am J Epidemiol.
2017 May 4. doi: 10.1093/aje/kwx097. [Epub ahead of print]
Janssen BG, et al. Fetal Thyroid Function, Birth Weight, and in Utero Exposure to Fine
Particle Air Pollution: A Birth Cohort Study. Environ Health Perspect; DOI:10.1289/EHP508
Basu R, et al. Association between PM2.5 and PM2.5 Constituents and Preterm Delivery in
California, 2000-2006. Paediatr Perinat Epidemiol. 2017 Jul 21. doi: 10.1111/ppe.12380.
[Epub ahead of print]
Clemens T, Turner S, Dibben C. Maternal exposure to ambient air pollution and fetal
growth in North-East Scotland: A population-based study using routine ultrasound scans.
Environ Int. 2017 Jul 25;107:216-226. doi: 10.1016/j.envint.2017.07.018. [Epub ahead of print]
Liu C, et al. Different exposure levels of fine particulate matter and preterm birth: a metaanalysis
based on cohort studies. Environ Sci Pollut Res Int. 2017 Jun 15. doi: 10.1007/
s11356-017-9363-0. [Epub ahead of print]
Mendola P, Ha S, Pollack AZ, Zhu Y, Seeni I, Kim SS, Sherman S, Liu D. Chronic and
Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth.Int
J Environ Res Public Health. 2017 Jul 6;14(7). pii: E731. doi: 10.3390/ijerph14070731.
Wang L, et al. The association between cooking oil fume exposure during pregnancy and
birth weight: A prospective mother-child cohort study. Sci Total Environ. 2017 Sep
4;612:822-830. doi: 10.1016/j.scitotenv.2017.08.031. [Epub ahead of print]
Clemens T, et al. Maternal exposure to ambient air pollution and fetal growth in North-
East Scotland: A population-based study using routine ultrasound scans. Environ Int. 2017
Oct;107:216-226. doi: 10.1016/j.envint.2017.07.018. Epub 2017 Jul 25.
Reis MMD, et al. Air pollution and low birth weight in an industrialized city in
96
Southeastern Brazil, 2003-2006. Rev Bras Epidemiol. 2017 Apr-Jun;20(2):189-199. doi:
10.1590/1980-5497201700020001.
Soto SF, et al. Exposure to fine particulate matter in the air alters placental structure and
the renin-angiotensin system. PLoS One. 2017 Aug 18;12(8):e0183314. doi: 10.1371/
journal.pone.0183314. eCollection 2017.
Blum J, et al. Exposure to Ambient Particulate Matter during Specific Gestational
Periods Produces Adverse Obstetric Consequences in Mice. Environmental Health
Perspectives, July 2017 DOI: 10.1289/EHP1029
Smith R, et al. Impact of London’s road traffic air and noise pollution on birth weight:
retrospective population based cohort study. BMJ, 2017; j5299 DOI: 10.1136/bmj.j5299
Dutta A, et al. Household air pollution and chronic hypoxia in the placenta of pregnant
Nigerian women: A randomized controlled ethanol Cookstove intervention. Sci Total Environ.
2017 Nov 14;619-620:212-220. doi: 10.1016/j.scitotenv.2017.11.091. [Epub ahead of print]
Ji Y, et al. Association between exposure to particulate matter during pregnancy and
birthweight: a systematic review and a meta-analysis of birth cohort studies. J Biomed Res.
2017 Nov 1. doi: 10.7555/JBR.31.20170038. [Epub ahead of print]
Wu H, et al. Exposure to fine particulate matter during pregnancy and risk of term low
birth weight in Jinan, China, 2014-2016. Int J Hyg Environ Health. 2017 Oct 28. pii:
S1438-4639(17)30399-1. doi: 10.1016/j.ijheh.2017.10.013. [Epub ahead of print]
Yang M, et al. The Impact of Environmental Regulation on Fetal Health: Evidence from
the Shutdown of a Coal-Fired Power Plant Located Upwind of New Jersey. Journal of
Environmental Economics and Management, 2017; DOI: 10.1016/j.jeem.2017.11.005
Ghasemi-Tehrani H, et al. Effect of Exposure to Air Pollution on Placental Weight in
Isfahan-Iran. J Family Reprod Health. 2017 Jun;11(2):90-96.
Wang YY, et al. Association of Long-term Exposure to Airborne Particulate Matter of 1
μm or Less With Preterm Birth in China. JAMA Pediatr. 2018 Jan 2:e174872. doi: 10.1001/
jamapediatrics.2017.4872. [Epub ahead of print]
Whitworth KW, et al. Drilling and Production Activity Related to Unconventional Gas
Development and Severity of Preterm Birth. Environ Health Perspect; DOI:10.1289/EHP2622
Wang Q, et al. Effects of prenatal exposure to air pollution on preeclampsia in Shenzhen,
China. Environ Pollut. 2018 Feb 18;237:18-27. doi: 10.1016/j.envpol.2018.02.010. [Epub
ahead of print]
Ren Z, et al. Maternal exposure to ambient PM10 during pregnancy increases the risk of
congenital heart defects: Evidence from machine learning models. Sci Total Environ. 2018 Feb
19;630:1-10. doi: 10.1016/j.scitotenv.2018.02.181. [Epub ahead of print]
Yang S, Tan Y, Mei H, Wang F, Li N, Zhao J, Zhang Y, Qian Z, Chang JJ, Syberg KM,
97
Peng A, Mei H, Zhang D, Zhang Y, Xu S, Li Y, Zheng T, Zhang B. Ambient air pollution the risk
of stillbirth: A prospective birth cohort study in Wuhan, China. Int J Hyg Environ Health. 2018
Feb 5. pii: S1438-4639(17)30531-X. doi: 10.1016/j.ijheh.2018.01.014. [Epub ahead of print]
PMID: 29422441 [PubMed – as supplied by publisher]
Li X, et al. Analysis of short-term and sub-chronic effects of ambient air pollution on
preterm birth in central China. Environ Sci Pollut Res Int. 2018 May 2. doi: 10.1007/
s11356-018-2061-8. [Epub ahead of print]
Casey JA, et al. Coal and oil power plant retirements in California associated with
reduced preterm birth among populations nearby. American Journal of Epidemiology, kwy110,
https://doi.org/10.1093/aje/kwy110. Published: 16 May 2018
Casey JA, et al. Increase in fertility following coal and oil power plant retirements in
California. Environ Health. 2018 May 2;17(1):44. doi: 10.1186/s12940-018-0388-8.
Xue T, et al. Association Between Hypertensive Disorders in Pregnancy and Particulate
Matter in the Contiguous United States, 1999-2004. Hypertension. 2018 May 21. pii:
HYPERTENSIONAHA.118.11080. doi: 10.1161/HYPERTENSIONAHA.118.11080. [Epub
ahead of print].
Grippo A, et al. Air pollution exposure during pregnancy and spontaneous abortion and
stillbirth. Rev Environ Health. 2018 Jul 5. pii: /j/reveh.ahead-of-print/reveh-2017-0033/
reveh-2017-0033.xml. doi: 10.1515/reveh-2017-0033. [Epub ahead of print]
Gong X et al. Associations between maternal residential proximity to air emissions from
industrial facilities and low birth weight in Texas, USA. Environ Int. 2018 Aug 7;120:181-198.
doi: 10.1016/j.envint.2018.07.045. [Epub ahead of print]
Wang L, et al. Association between early prenatal exposure to ambient air pollution and
birth defects: evidence from newborns in Xi’an, China. J Public Health (Oxf). 2018 Aug 18. doi:
10.1093/pubmed/fdy137. [Epub ahead of print]
He T, et al. Ambient air pollution, H19/DMR methylation in cord blood and newborn size:
A pilot study in Zhengzhou City, China. Chemosphere. 2018 Aug 30;212:863-871. doi:
10.1016/j.chemosphere.2018.08.140. [Epub ahead of print]
Barn P, et al. The effect of portable HEPA filter air cleaner use during pregnancy on fetal
growth: The UGAAR randomized controlled trial. Environ Int. 2018 Sep 10. pii:
S0160-4120(18)31141-3. doi: 10.1016/j.envint.2018.08.036. [Epub ahead of print]
Wang Q, et al. Identifying windows of susceptibility for maternal exposure to ambient air
pollution and preterm birth. Environ Int. 2018 Sep 18;121(Pt 1):317-324. doi: 10.1016/j.envint.
2018.09.021. [Epub ahead of print]
Liu WY, et al. Association between ambient air pollutants and preterm birth in Ningbo,
China: a time-series study. BMC Pediatr. 2018 Sep 20;18(1):305. doi: 10.1186/
98
s12887-018-1282-9.
Arinola GO, et al. Household Air Pollution, Levels of Micronutrients and Heavy Metals in
Cord and Maternal Blood, and Pregnancy Outcomes. Int J Environ Res Public Health. 2018
Dec 17;15(12). pii: E2891. doi: 10.3390/ijerph15122891.
Norlén F, et al. Occupational exposure to inorganic particles during pregnancy and birth
outcomes: a nationwide cohort study in Sweden. BMJ Open. 2019 Feb 27;9(2):e023879. doi:
10.1136/bmjopen-2018-023879.
Li R, et al. Term birth weight and ambient air pollutant concentrations during pregnancy,
among women living in Monroe County, New York. J Expo Sci Environ Epidemiol. 2019 Apr 2.
doi: 10.1038/s41370-019-0131-8. [Epub ahead of print]
Franklin P, et al. Maternal Exposure to Indoor Air Pollution and Birth Outcomes. Int J
Environ Res Public Health. 2019 Apr 16;16(8). pii: E1364. doi: 10.3390/ijerph16081364.

Air Pollution and Cancer

Air pollution is associated with higher rates of breast, lung, prostate, cervical, brain, nasal, pharyngeal, liver, pancreatic and stomach cancer, and childhood leukemia. Prenatal pollution exposure is associated with increased rates of multiple childhood cancers.
Air pollution is associated with decreased survival in patients will all types of cancer, especially breast cancer.
The World Health Organization has declared air pollution the most important environmental cause of cancer, more important that second hand cigarette smoke. The WHO placed it in the same category as asbestos and ionizing radiation

Raaschou-Nielsen O, Andersen Z, Hvidberg M, Jensen SS, Ketzel M, Sørensen M, Loft S,
Overvad K, Tjønneland A. Lung Cancer Incidence and Long-Term Exposure to Air Pollution
from Traffic. Environ Health Perspect. 2011 Jan 12. [Epub ahead of print]
99
Crouse DL, Goldberg MS, Ross NA, Chen H, Labrèche F 2010. Postmenopausal Breast
Cancer Is Associated with Exposure to Traffic-Related Air Pollution in Montreal, Canada: A
Case–Control Study. Environ Health Perspect 118:1578-1583. doi:10.1289/ ehp.1002221
Pearson RL, Wachtel H, Ebi KL. Distance-weighted traffic density in proximity to a home is a
risk factor for leukemia and other childhood cancers. J Air Waste Manag Assoc 50(2):175-180.
Weng HH, Tsai SS, Chen CC, Chiu HF, Wu TN, Yang CYJ. Childhood leukemia development
and correlation with traffic air pollution in Taiwan using nitrogen dioxide as an air pollutant
marker. Toxicol Environ Health A. 2008;71(7):434-8.
Langholz B, et al.; Traffic density and the risk of childhood leukemia in a Los Angeles casecontrol
study. Ann. Epi. 2002 Oct; 12(7):482-7.
Raaschou-Nielsen O, Andersen ZJ, Hvidberg M, Jensen SS, Ketzel M, Sørensen M, Hansen J,
Loft S, Overvad K, Tjønneland A. Air pollution from traffic and cancer incidence: a Danish
cohort study. Environ Health. 2011 Jul 19;10:67. doi: 10.1186/1476-069X-10-67.
Luo J, Margolis K, Wactawski-Wende J, et al. Association of active and passive smoking with
risk of breast cancer among postmenopausal women: a prospective cohort study. BMJ 2011;
342:d1016
Amigou A, Sermage-Faure C, Orsi L, Leverger G, Baruchel A, Bertrand Y, et al. 2011. Road
Traffic and Childhood Leukemia: The ESCALE Study (SFCE). Environ Health Perspect
119:566-572. doi:10.1289/ehp.1002429
Weng HH, Tsai SS, Chiu HF, Wu TN, Yang CY. Childhood leukemia and traffic air pollution
in Taiwan: petrol station density as an indicator.J Toxicol Environ Health A. 2009;72(2):83-7.
doi: 10.1080/15287390802477338.
Chiu HF, Tsai SS, Chen PS, Liao YH, Liou SH, Wu TN, Yang CY. Traffic air pollution and
risk of death from gastric cancer in taiwan: petrol station density as an indicator of air
pollutant exposure. J Toxicol Environ Health A. 2011 Sep 15;74(18): 1215-24.
Grant WB. Air pollution in relation to U.S. cancer mortality rates: an ecological study;
likely role of carbonaceous aerosols and polycyclic aromatic hydrocarbons. Anticancer Res.
2009 Sep;29(9):3537-45.
Turner MC, Krewski D, Pope Iii CA, Chen Y, Gapstur SM, Thun MJ. Long-Term Ambient
Fine Particulate Matter Air Pollution and Lung Cancer in a Large Cohort of Never Smokers.
Am J Respir Crit Care Med. 2011 Oct 6. [Epub ahead of print] PubMed PMID: 21980033.
Hung LJ, Chan TF, Wu CH, Chiu HF, Yang CY. Traffic Air Pollution and Risk of Death
from Ovarian Cancer in Taiwan: Fine Particulate Matter (PM(2.5)) as a Proxy Marker. J
Toxicol Environ Health A. 2012 Feb 1;75(3):174-82.
Silverman DT, Samanic CM, Lubin JH, et al. The diesel exhaust in miners study: a nested
case-control study of lung cancer and diesel exhaust. J Natl Cancer Inst. March 2, 2012. doi:
100
10.1093/jnci/djs034.
Attfield MD, Schlieff PL, Lubin JH, et al. The diesel exhaust in miners study: a cohort
mortality study with emphasis on lung cancer. J Natl Cancer Inst. March 2, 2012. doi:10.1093/
jnci/djs035.
Vinceti M, Rothman KJ, Crespi CM, Sterni A, Cherubini A, Guerra L, Maffeis G, Ferretti E,
Fabbi S, Teggi S, Consonni D, De Girolamo G, Meggiato A, Palazzi G, Paolucci P, Malagoli C.
Leukemia risk in children exposed to benzene and PM(10) from vehicular traffic: a case-control
study in an Italian population. Eur J Epidemiol. 2012 Aug 15. [Epub ahead of print]
Yorifuji T, Kashima S, Tsuda T, Ishikawa-Takata K, Ohta T, Tsuruta KI, Doi H. Long- term
exposure to traffic-related air pollution and the risk of death from hemorrhagic stroke and lung
cancer in Shizuoka, Japan. Sci Total Environ. 2012 Nov 30;443C: 397-402. doi: 10.1016/
j.scitotenv.2012.10.088. [Epub ahead of print]
Parent ME, Goldberg MS, Crouse DL, Ross NA, Chen H, Valois MF, Liautaud A. Trafficrelated
air pollution and prostate cancer risk: a case-control study in Montreal, Canada. Occup
Environ Med. 2013 Mar 26. [Epub ahead of print]
Williams ES, Mahler B, Van Metre P. Cancer Risk from Incidental Ingestion Exposures to
PAHs Associated with Coal-Tar-Sealed Pavement. Environmental Science & Technology, 2013;
47 (2): 1101 DOI: 10.1021/es303371t
Prenatal air pollution associated higher rates of retinoblastomas, ALL, and germ cell
tumors. http://www.aacr.org/home/public–media/aacr-in-the-news.aspx?d=3062
Hu H, Dailey AB, Kan H, Xu X. The effect of atmospheric particulate matter on survival of
breast cancer among US females. Breast Cancer Res Treat. 2013 Apr 17. [Epub ahead of print]
Ghosh JK, Heck JE, Cockburn M, Su J, Jerrett M, Ritz B. Prenatal Exposure to Trafficrelated
Air Pollution and Risk of Early Childhood Cancers. Am J Epidemiol. 2013 Aug 28.
[Epub ahead of print]
Bulka C, et al. Residence Proximity to Benzene Release Sites Is Associated With Increased
Incidence of Non-Hodgkin Lymphoma. Cancer. Article first published online: 29 JUL 2013.
DOI: 10.1002/cncr.28083
Ho CK, Peng CY, Yang CY. Traffic air pollution and risk of death from bladder cancer in
Taiwan using petrol station density as a pollutant indicator. J Toxicol Environ Health A.
2010;73(1):23-32. doi: 10.1080/15287390903248869.
Liu CC, Chen CC, Wu TN, Yang CY. Association of brain cancer with residential exposure
to petrochemical air pollution in Taiwan. J Toxicol Environ Health A. 2008;71(5):310-4. doi:
10.1080/15287390701738491.
Boothe VL, Boehmer TK, Wendel AM, Yip FY. Residential Traffic Exposure and Childhood
101
Leukemia: A Systematic Review and Meta-analysis. Am J Prev Med. 2014 Apr;46(4):413-22.
doi: 10.1016/j.amepre.2013.11.004.
PMID: 24650845 [PubMed – in process]
Puett RC, Hart JE, Yanosky JD, Spiegelman D, Wang M, Fisher JA, Hong B, Laden F.
Particulate Matter Air Pollution Exposure, Distance to Road, and Incident Lung Cancer in the
Nurses’ Health Study Cohort. Environ Health Perspect. 2014 Jun 3. [Epub ahead of print]
Hamra GB, Guha N, Cohen A, Laden F, Raaschou-Nielsen O, Samet JM, Vineis P,
Forastiere F, Saldiva P, Yorifuji T, Loomis D. Outdoor Particulate Matter Exposure and Lung
Cancer: A Systematic Review and Meta-Analysis. Environ Health Perspect. 2014 Jun 6. [Epub
ahead of print]
Scheurer ME, Danysh HE, Follen M, Lupo PJ. Association of traffic-related hazardous air
pollutants and cervical dysplasia in an urban multiethnic population: a cross-sectional study.
Environ Health. 2014 Jun 13;13(1):52. [Epub ahead of print]
Heck JE, Wu J, Lombardi C, Qiu J, Meyers TJ, Wilhelm M, Cockburn M, Ritz B. Childhood
cancer and traffic-related air pollution exposure in pregnancy and early life. Environ Health
Perspect. 2013 Nov-Dec;121(11-12):1385-91. doi: 10.1289/ehp. 1306761. Epub 2013 Sep 9.
Cui P, Huang Y, Han J, Song F, Chen K. Ambient particulate matter and lung cancer
incidence and mortality: a meta-analysis of prospective studies. Eur J Public Health. 2014 Sep
pii: cku145. [Epub ahead of print]
Scheurer ME, Danysh HE, Follen M, Lupo PJ. Association of traffic-related hazardous air
pollutants and cervical dysplasia in an urban multiethnic population: a cross-sectional study.
Environ Health. 2014 Jun 13;13(1):52. doi: 10.1186/1476-069X-13-52.
Luanpitpong S, Chen M, Knuckles T, Wen S, Luo J, Ellis E, Hendryx M, Rojanasakul Y.
Appalachian Mountaintop Mining Particulate Matter Induces Neoplastic Transformation of
Human Bronchial Epithelial Cells and Promotes Tumor Formation. Environ Sci Technol. 2014
Oct 27. [Epub ahead of print]
Greenop KR, Hinwood AL, Fritschi L, Scott RJ, Attia J, Ashton LJ, Heath JA, Armstrong
BK, Milne E. Vehicle refueling, use of domestic wood heaters and the risk of childhood brain
tumours: Results from an Australian case-control study. Pediatr Blood Cancer. 2014 Oct 4. doi:
10.1002/pbc.25268. [Epub ahead of print]
Arrieta O, et al. Clinical and pathological characteristics, outcome and mutational profiles
regarding non-small-cell lung cancer related to wood-smoke exposure.J Thorac Oncol. 2012
Aug;7(8):1228-34. doi: 10.1097/JTO.0b013e3182582a93.
Hernández-Garduño E, et al. Wood smoke exposure and lung adenocarcinoma in nonsmoking
Mexican women. Int J Tuberc Lung Dis. 2004 Mar;8(3):377-83.
Javier Pintos J, et al. Use of wood stoves and risk of cancers of the upper aero- digestive
102
tract: a case-control study. Int. J. Epidemiol. (1998) 27 (6): 936-940 doi: 10.1093/ije/27.6.936
Ding N, Zhou N, Zhou M, Ren GM. Respiratory cancers and pollution. Eur Rev Med
Pharmacol Sci. 2015 Jan;19(1):31-7.
Yang WS, Zhao H, Wang X, Deng Q, Fan WY, Wang L. An evidence-based assessment for
the association between long-term exposure to outdoor air pollution and the risk of lung cancer.
Eur J Cancer Prev. 2015 Mar 9. [Epub ahead of print]
Chen G, Wan X, Yang G, Zou X. Traffic-related air pollution and lung cancer: A metaanalysis.
Thorac Cancer. 2015 May;6(3):307-18. doi: 10.1111/1759-7714.12185. Epub 2015
Apr 24.
Hart J, et al. Long-Term Ambient Residential Traffic–Related Exposures and
Measurement Error–Adjusted Risk of Incident Lung Cancer in the Netherlands Cohort Study on
Diet and Cancer. Environ Health Perspect; DOI:10.1289/ehp.1408762
Raaschou-Nielsen O, et al. Traffic-related air pollution and risk for leukaemia of an adult
population. Int J Cancer. 2015 Sep 28. doi: 10.1002/ijc.29867. [Epub ahead of print]
Hoot, J. et al. Residential Proximity to Heavy-Traffic Roads, Benzene Exposure, and
Childhood Leukemia—The GEOCAP Study, 2002–2007. American Journal of Epidemiology
Volume 182, Issue 8Pp. 685-693
von Ehrenstein O, et al. In Utero and Early-Life Exposure to Ambient Air Toxics and
Childhood Brain Tumors: A Population-Based Case–Control Study in California, USA.
Environ Health Perspect; DOI:10.1289/ehp.1408582
Pan W, et al. Fine Particle Pollution, Alanine Transaminase, and Liver Cancer: A
Taiwanese Prospective Cohort Study (REVEAL-HBV). J Natl Cancer Inst. 2015 Nov 11;108(3).
pii: djv341. doi: 10.1093/jnci/djv341. Print 2015 Mar.
Guo Y, et al. The association between lung cancer incidence and ambient air pollution in
China: A spatiotemporal analysis. Environ Res. 2015 Nov 9;144(Pt A):60-65. doi: 10.1016/
j.envres.2015.11.004. [Epub ahead of print]
Spycher BD, et al. Childhood cancer and residential exposure to highways: a nationwide
cohort study. Eur J Epidemiol. 2015 Nov 2. [Epub ahead of print]
Raaschou-Nielsen O, et al. Environ Int. 2015 Nov 28;87:66-73. doi: 10.1016/j.envint.
2015.11.007. [Epub ahead of print]. Particulate matter air pollution components and risk for
lung cancer.
White AJ, et al. Sources of polycyclic aromatic hydrocarbons are associated with genespecific
promoter methylation in women with breast cancer. Environ Res. 2015 Dec
6;145:93-100. doi: 10.1016/j.envres.2015.11.033. [Epub ahead of print]
Raaschou-Nielsen O, Andersen Z, Beelen R, et al. Air pollution and lung cancer incidence in
17 European cohorts: prospective analyses from the European Study of Cohorts for Air
103
Pollution Effects (ESCAPE). The Lancet. Published online July 10 2013
Poulsen AH, et al. Air pollution from traffic and risk for brain tumors: a nationwide study
in Denmark. Cancer Causes Control. 2016 Feb 18. [Epub ahead of print]
Wong CM, et al. Cancer Mortality Risks from Long-term Exposure to Ambient Fine
Particle. Cancer Epidemiol Biomarkers Prev; Published OnlineFirst April 29, 2016; doi
10.1158/1055-9965.EPI-15-0626
Janitza AE, et al. Traffic-related air pollution and childhood acute leukemia in Oklahoma.
Environmental Research. Volume 148, July 2016, Pages 102–111
Tomczak A, et al. Long-term exposure to fine particulate matter air pollution and the risk
of lung cancer among participants of the Canadian National Breast Screening Study. Int J
Cancer. 2016 Jul 6. doi: 10.1002/ijc.30255. [Epub ahead of print]
von Ehrenstein O, et al. In Utero and Early-Life Exposure to Ambient Air Toxics and
Childhood Brain Tumors: A Population-Based Case–Control Study in California, USA Environ
Health Perspect; DOI:10.1289/ehp.1408582
Visani G, et al. Environmental nanoparticles are significantly over-expressed in acute
myeloid leukemia. Leuk Res. 2016 Nov;50:50-56.
Elliott EG, Trinh P, Ma X, Leaderer BP, Ward MH, Deziel NC. Unconventional oil and gas
development and risk of childhood leukemia: Assessing the evidence. Sci Total Environ. 2016
Oct 23;576:138-147. doi: 10.1016/j.scitotenv.2016.10.072. [Epub ahead of print]
Cohen G, et al. Long-term exposure to traffic-related air pollution and cancer among
survivors of myocardial infarction: A 20-year follow-up study. Eur J Prev Cardiol. 2016 Sep
pii: 2047487316669415. [Epub ahead of print]
Pedersen M, et al. Ambient air pollution and primary liver cancer incidence in four
European cohorts within the ESCAPE project. Environ Res. 2017 Jan 17;154:226-233. doi:
10.1016/j.envres.2017.01.006. [Epub ahead of print]
Gharibvand L, et al. The Association between Ambient Fine Particulate Air Pollution and
Lung Cancer Incidence: Results from the AHSMOG-2 Study. Environ Health Perspect; DOI:
10.1289/EHP124
Sifaki-Pistolla D, Lionis C, Koinis F, Georgoulias V, Tzanakis N; On behalf of the Cancer
Registry of Crete (CRC). Lung cancer and annual mean exposure to outdoor air pollution in
Crete, Greece. Eur J Cancer Prev. 2017 Jul 25. doi: 10.1097/CEJ.0000000000000407. [Epub
ahead of print]
White AJ, et al. Indoor Wood-Burning Stove and Fireplace Use and Breast Cancer in a
Prospective Cohort Study. Environ Health Perspect. 2017 Jul 18;125(7):077011. doi: 10.1289/
EHP827.
Large C, Wei Y. Geographic variations in female breast cancer incidence in relation to
104
ambient air emissions of polycyclic aromatic hydrocarbons. Environ Sci Pollut Res Int. 2017
Jun 14. doi: 10.1007/s11356-017-9395-5. [Epub ahead of print]
Goldberg MS, et al. The association between the incidence of postmenopausal breast
cancer and concentrations at street-level of nitrogen dioxide and ultrafine particles. Environ
Res. 2017 Jun 5;158:7-15. doi: 10.1016/j.envres.2017.05.038. [Epub ahead of print]
Deng H, et al. Particulate matter air pollution and liver cancer survival. Int J Cancer.
2017 Jun 7. doi: 10.1002/ijc.30779. [Epub ahead of print]
García-Pérez J, López-Cima MF, Pérez-Gómez B, Aragonés N, Pollán M, Vidal E, et al.
Mortality due to tumours of the digestive system in towns lying in the vicinity of metal
production and processing installations. Sci Total Environ 2010;408:3102–12.
Sapkota A, Zaridze D, Szeszenia-Dabrowska N, Mates D, Fabiánová E, Rudnai P ,. Indoor
air pollution from solid fuels and risk of upper aerodigestive tract cancers in central and
eastern Europe. Environ Res 2013;120:90–5
Collarile P, et al. Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and
Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study:
1995-2009. Int J Environ Res Public Health. 2017 Jul 31;14(8). pii: E860. doi: 10.3390/
ijerph14080860.
Andersen Z, et al. Long-term Exposure to Ambient Air Pollution and Incidence of Brain
Tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE). Neuro Oncol. 2017
Aug 31. doi: 10.1093/neuonc/nox163. [Epub ahead of print]
Lamichhane DK, et al. Lung Cancer Risk and Residential Exposure to Air Pollution: A
Korean Population-Based Case-Control Study. Yonsei Med J. 2017 Nov;58(6):1111-1118. doi:
10.3349/ymj.2017.58.6.1111.
Turner MC, et al. Ambient Air Pollution and Cancer Mortality in the Cancer Prevention
Study II. Environ Health Perspect. 2017 Aug 21;125(8):087013.
Liao Y, et al. Temporal Trend in Lung Cancer Burden Attributed to Ambient Fine
Particulate Matter in Guangzhou, China. Biomed Environ Sci. 2017 Oct;30(10):708-717. doi:
10.3967/bes2017.096.
Delgado J, et al. Lung Cancer Pathogenesis Associated With Wood Smoke Exposure
July 2005. Volume 128, Issue 1, Pages 124–131
Nagel G, et al. Air pollution and incidence of cancers of the stomach and the upper
aerodigestive tract in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Int J
Cancer. 2018 Apr 26. doi: 10.1002/ijc.31564. [Epub ahead of print]
Ljubimova, JY, et al. Coarse particulate matter (PM2.5–10) in Los Angeles Basin air
induces expression of inflammation and cancer biomarkers in rat brains. Scientific Reports,
105
2018; 8 (1) DOI: 10.1038/s41598-018-23885-3
Consonni D, et al. Outdoor particulate matter (PM10) exposure and lung cancer risk in the
EAGLE study. PLoS One. 2018 Sep 14;13(9):e0203539. doi: 10.1371/journal.pone.0203539.
eCollection 2018.
Weinmayr G, et al. Particulate matter air pollution components and incidence of cancers of
the stomach and the upper aerodigestive tract in the European Study of Cohorts of Air Pollution
Effects (ESCAPE). Environ Int. 2018 Aug 7;120:163-171. doi: 10.1016/j.envint.2018.07.030.
[Epub ahead of print]
Ribeiro AG, et al. Incidence and mortality risk for respiratory tract cancer in the city of
São Paulo, Brazil: Bayesian analysis of the association with traffic density. Cancer Epidemiol.
2018 Jul 23;56:53-59. doi: 10.1016/j.canep.2018.07.005. [Epub ahead of print]
Seifi M, et al. Exposure to ambient air pollution and risk of childhood cancers: A
population-based study in Tehran, Iran. Sci Total Environ. 2018 Jul 24;646:105-110. doi:
10.1016/j.scitotenv.2018.07.219. [Epub ahead of print]
Cheng I, et al. Association between ambient air pollution and breast cancer risk: The
Multiethnic Cohort Study. Int J Cancer. 2019 Mar 28. doi: 10.1002/ijc.32308. [Epub ahead of
print]

Air Pollution and Metabolic Disorders

More exposure to air pollution, even short term, decreases insulin sensitivity, glucose tolerance, increases rates of Type I and Type II diabetes, and promotes obesity and metabolic syndrome.
- Prenatal exposure has a particularly strong association with childhood obesity.
- Good cholesterol (HDL) is decreased, and bad cholesterol (LDL) is increased with more
  air pollution

Pearson J, Bachireddy C, Shyamprasad S, Goldfine A, Brownstein J. Association Between
106
Fine Particulate Matter and Diabetes Prevalence in the U.S.Diabetes Care October 2010
33:2196-2201; published ahead of print July 13, 2010, doi:10.2337/ dc10-0698
Krämer U, Herder C, Sugiri D, Strassburger K, Schikowski T, Ranft U, et al. 2010. Trafficrelated
Air Pollution and Incident Type 2 Diabetes: Results from the SALIA Cohort Study.
Environ Health Perspect :-. doi:10.1289/ehp.0901689
Puett RC, Hart JE, Schwartz J, Hu FB, Liese AD, Laden F 2011. Are Particulate Matter
Exposures Associated with Risk of Type 2 Diabetes? Environ Health Perspect 119:384-389. doi:
10.1289/ehp.1002344
Zou M. Is NAD(P)H Oxidase a Missing Link for Air Pollution–Enhanced Obesity?
Arterioscler Thromb Vasc Biol. 2010;30:2323-2324, doi:10.1161/ATVBAHA.110.216648
Toperoff G, Aran D, Kark J, Rosenberg M, et al. Genome-wide survey reveals predisposing
diabetes type 2-related DNA methylation variations in human peripheral blood. Hum. Mol.
Genet. (2012) 21(2): 371-383 doi:10.1093/hmg/ddr472
Makaji E, Raha S, Wade MG, Holloway AC. Effect of environmental contaminants on Beta
cell function. Int J Toxicol. 2011 Aug;30(4):410-8. Epub 2011 Jun 24.
Coogan PF, White LF, Jerrett M, Brook RD, Su JG, Seto E, Burnett R, Palmer JR, Rosenberg
L. Air Pollution and Incidence of Hypertension and Diabetes in African American Women
Living in Los Angeles. Circulation. 2012 Jan 4. [Epub ahead of print]
Xu X, Liu C, Xu Z, Tzan K, et al. Long-term Exposure to Ambient Fine Particulate Pollution
Induces Insulin Resistance and Mitochondrial Alteration in Adipose Tissue. Toxicological
Sciences Volume 124, Issue 1Pp. 88-98
Rundle A, Hoepner L, Hassoun A, et al. Association of Childhood Obesity With Maternal
Exposure to Ambient Air Polycyclic Aromatic Hydrocarbons During Pregnancy. Am. J.
Epidemiol. online April 13, 2012 doi:10.1093/aje/kwr45
Bolton J, Smith S, Huff N, Gilmour MI, Foster WM, Auten R, and Bilbo S. Prenatal air
pollution exposure induces neuroinflammation and predisposes offspring to weight gain in
adulthood in a sex-specific manner FASEB J fj.12-210989; published ahead of print July 19,
2012, doi:10.1096/fj.12-210989
Raaschou-Nielsen O, Sørensen M, Ketzel M, Hertel O, Loft S, Tjønneland A, Overvad K,
Andersen ZJ. Long-term exposure to traffic-related air pollution and diabetes-associated
mortality: a cohort study. Diabetologia. 2012 Aug 24. [Epub ahead of print]
Liu C, Ying Z, Harkema J, Sun Q, Rajagopalan S. Epidemiological and Experimental Links
between Air Pollution and Type 2 Diabetes. Toxicol Pathol. 2012 Oct 26. [Epub ahead of print]
Khafaie MA, Salvi SS, Ojha A, Khafaie B, Gore SS, Yajnik CS. Systemic Inflammation (CReactive
Protein) in Type 2 Diabetic Patients Is Associated With Ambient Air Pollution in Pune
City, India. Diabetes Care. 2012 Nov 19. [Epub ahead of print]
107
He K, Xun P, Liu K, Morris S, Reis J, Guallar E. Mercury Exposure in Young Adulthood and
Incidence of Diabetes Later in Life:The CARDIA trace element study. Published online before
print February 19, 2013, doi: 10.2337/dc12-1842 Diabetes Care February 19, 2013
Chen H, Burnett RT, Kwong JC, Villeneuve PJ, Goldberg MS, Brook RD, van Donkelaar A,
Jerrett M, Martin RV, Brook JR, Copes R. Risk of Incident Diabetes in Relation to Long-term
Exposure to Fine Particulate Matter in Ontario, Canada. Environ Health Perspect (): .doi:
10.1289/ehp.1205958
Thiering E, Cyrys J, Kratzsch J, Meisinger C, Hoffmann B, Berdel D, von Berg A, Koletzko
S, Bauer CP, Heinrich J. Long-term exposure to traffic-related air pollution and insulin
resistance in children: results from the GINIplus and LISAplus birth cohorts Diabetologia, DOI
10.1007/s00125-013-2925-x
Brook RD, Cakmak S, Turner MC, Brook JR, Crouse DL, Peters PA, van Donkelaar A,
Villeneuve PJ, Brion O, Jerrett M, Martin RV, Rajagopalan S, Goldberg MS, Pope CA 3rd,
Burnett RT. Long-Term Fine Particulate Matter Exposure and Mortality From Diabetes
Mellitus in Canada. Diabetes Care. 2013 Jun 18. [Epub ahead of print]
Liu C, et al. Air Pollution–. Susceptibility to Inflammation and Insulin Resistance: Influence
of CCR2 Pathways in Mice. Environ Health Perspect; DOI:10.1289/ehp. 1306841
Tamayo T, Rathmann W, Krämer U, Sugiri D, Grabert M, Holl RW. Is particle pollution in
outdoor air associated with metabolic control in type 2 diabetes? PLoS One. 2014 Mar
11;9(3):e91639. doi: 10.1371/journal.pone.0091639. eCollection 2014.
Fleisch AF, DR Gold, SL Rifas-Shiman, P Koutrakis, JD Schwartz, I Kloog, S Melly, BA
Coull, A Zanobetti, MW Gillman, E Oken. 2014. Air pollution exposure and abnormal glucose
tolerance during pregnancy: the Project Viva cohort. Environmental Health Perspectives. http://
dx.doi.org/10.1289/ehp.1307065.
Nemmar A, Al-Salam S, Beegam S, Yuvaraju P, Yasin J, Ali BH. Cell Physiol Biochem. 2014
Feb 11;33(2):413-422. [Epub ahead of print] Pancreatic Effects of Diesel Exhaust Particles in
Mice with Type 1 Diabetes Mellitus
Jerrett M, McConnell R, Wolch J, Chang R, Lam C, Dunton G, Gilliland F, Lurmann F,
Islam T, Berhane K. Traffic-related air pollution and obesity formation in children: a
longitudinal, multilevel analysis. Environ Health. 2014 Jun 9;13(1):49. [Epub ahead of print]
Park SK, Wang W. Ambient Air Pollution and Type 2 Diabetes: A Systematic Review of
Epidemiologic Research. Curr Environ Health Rep. 2014 Sep 1;1(3): 275-286.
Wang Y, Eliot MN, Kuchel GA, Schwartz J, Coull BA, Mittleman MA, Lipsitz LA, Wellenius
GA. Long-Term Exposure to Ambient Air Pollution and Serum Leptin in Older Adults: Results
From the MOBILIZE Boston Study. J Occup Environ Med. 2014 Sep;56(9):e73-e77.
Teichert T, Vossoughi M, Vierkötter A, Sugiri D, Schikowski T, Schulte T, Roden M,
108
Luckhaus C, Herder C, Krämer U. Association between traffic-related air pollution, subclinical
inflammation and impaired glucose metabolism: results from the SALIA study. PLoS One. 2013
Dec 10;8(12):e83042. doi: 10.1371/journal.pone.0083042. eCollection 2013.
Li C, Fang D, Xu D, Wang B, Zhao S, Yan S, Wang Y. MECHANISMS IN
ENDOCRINOLOGY: Main air pollutants and diabetes-associated mortality: a systematic
review and meta-analysis. Eur J Endocrinol. 2014 Nov;171(5):R183-R190.
Wang B, Xu D, Jing Z, Liu D, Yan S, Wang Y. MECHANISMS IN ENDOCRINOLOGY:
Effect of long-term exposure to air pollution on type 2 diabetes mellitus risk: a systemic review
and meta-analysis of cohort studies. Eur J Endocrinol. 2014 Nov;171(5):R173-R182.
Vella RE, Pillon NJ, Zarrouki B, Croze ML, Koppe L, Guichardant M, Pesenti S, Chauvin
MA, Rieusset J, Géloën A, Soulage CO. Ozone exposure triggers insulin resistance through
muscle c-Jun N-terminal Kinases (JNKs) activation. Diabetes. 2014 Oct 2. pii: DB_131181.
[Epub ahead of print]
Park SK, Adar SD, O’Neill MS, Auchincloss AH, Szpiro A, Bertoni AG, Navas- Acien A,
Kaufman JD, Diez-Roux AV. Long-Term Exposure to Air Pollution and Type 2 Diabetes
Mellitus in a Multiethnic Cohort. Am J Epidemiol. 2015 Feb 17. pii: kwu280. [Epub ahead of
print]
Meo SA, et al. Effect of environmental air pollution on type 2 diabetes mellitus. Eur Rev Med
Pharmacol Sci. 2015 Jan;19(1):123-8.
Bodin J, Stene LC, Nygaard UC. Can Exposure to Environmental Chemicals Increase the
Risk of Diabetes Type 1 Development? Biomed Res Int. 2015;2015:208947. Epub 2015 Mar 26.
Malmqvist E. Maternal exposure to air pollution and type 1 diabetes – Accounting for
genetic factors. Environ Res. 2015 Apr 13;140:268-274. doi: 10.1016/j.envres.2015.03.024.
[Epub ahead of print]
Esposito K, Petrizzo M, Maiorino MI, Bellastella G, Giugliano D. Particulate matter
pollutants and risk of type 2 diabetes: a time for concern? Endocrine. 2015 May 30. [Epub
ahead of print]
Thiering E, Heinrich J. Epidemiology of air pollution and diabetes. Trends Endocrinol
Metab. 2015 Jun 8. pii: S1043-2760(15)00084-3. doi: 10.1016/j.tem. 2015.05.002. [Epub ahead
of print]
Chen Z, et al. Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose
Homeostasis in Mexican Americans. Diabetes Care. 2016 Feb 11. pii: dc151795. [Epub ahead
of print]
Thiering E, et al. Associations of Residential Long-Term Air Pollution Exposures and
Satellite-Derived Greenness with Insulin Resistance in German Adolescents. Environ Health
Perspect. 2016 Feb 5. [Epub ahead of print]
109
Wei Y, et al. Chronic exposure to air pollution particles increases the risk of obesity and
metabolic syndrome: findings from a natural experiment in Beijing. FASEB J. 2016 Feb 18. pii:
fj.201500142. [Epub ahead of print]
Hansen AB, et al. Long-term exposure to fine particulate matter and incidence of diabetes
in the Danish Nurse Cohort. Environ Int. 2016 Mar 15;91:243-250. doi: 10.1016/j.envint.
2016.02.036. [Epub ahead of print]
Haberzettl P, O’Toole TE, Bhatnagar A, Conklin DJ. Exposure to Fine Particulate Air
Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress. Environ
Health Perspect. 2016 Apr 29. [Epub ahead of print]
Lavigne E, et al. Air Pollution Exposure During Pregnancy and Fetal Markers of
Metabolic Function: The MIREC Study. Am J Epidemiol. 2016 Mar 29. pii: kwv256. [Epub
ahead of print]
Liu C, et al. Associations between long-term exposure to ambient particulate air pollution
and type 2 diabetes prevalence, blood glucose and glycosylated hemoglobin levels in China.
Environ Int. 2016 May 2;92-93:416-421. doi: 10.1016/j.envint.2016.03.028. [Epub ahead of
print]
Eze IC, et al. Air pollution and diabetes association: Modification by type 2 diabetes
genetic risk score. Environ Int. 2016 Jun 6;94:263-271. doi: 10.1016/j.envint.2016.04.032.
[Epub ahead of print]
Goettems-Fiorin PB, et al. Fine particulate matter potentiates type 2 diabetes development
in high-fat diet-treated mice: stress response and extracellular to intracellular HSP70 ratio
analysis. J Physiol Biochem. 2016 Jun 29. [Epub ahead of print]
Wolf K, Popp A, Schneider A, Breitner S, Hampel R, Rathmann W, Herder C, Roden M,
Koenig W, Meisinger C, Peters A; Association Between Long-Term Exposure to Air Pollution
and Biomarkers Related to Insulin Resistance, Subclinical Inflammation and Adipokines.
Diabetes. 2016 Sep 7. pii: db151567. [Epub ahead of print]
He D, et al. Association between Particulate Matter 2.5 and Diabetes Mellitus- a Meta-
Analysis of Cohort Studies. J Diabetes Investig. 2017 Jan 25. doi: 10.1111/jdi.12631. [Epub
ahead of print]
Alderete T, et al. Longitudinal Associations Between Ambient Air Pollution with Insulin
Sensitivity, β-Cell Function, and Adiposity in Los Angeles Latino Children. Diabetes 2017 Jan;
db161416. https://doi.org/10.2337/db16-1416
Madhloum N, et al. Cord plasma insulin and in utero exposure to ambient air pollution.
Environ Int. 2017 May 22. pii: S0160-4120(16)30886-8. doi: 10.1016/j.envint.2017.05.012.
[Epub ahead of print]
Strak M, et al. Long-term exposure to particulate matter, NO2 and the oxidative potential
110
of particulates and diabetes prevalence in a large national health survey. Environ Int. 2017 Sep
5;108:228-236. doi: 10.1016/j.envint.2017.08.017. [Epub ahead of print]
Mazidi M, et al. Ambient particulate air pollution (PM2.5) is associated with the ratio of
type 2 diabetes to obesity. Sci Rep. 2017 Aug 22;7(1):9144. doi: 10.1038/s41598-017-08287-1.
Alderete TL, et al. Prenatal traffic-related air pollution exposures, cord blood adipokines
and infant weight. Pediatr Obes. 2017 Nov 3. doi: 10.1111/ijpo.12248. [Epub ahead of print]
Khafaie MA, et al. Particulate matter and markers of glycemic control and insulin
resistance in type 2 diabetic patients: result from Wellcome Trust Genetic study. J Expo Sci
Environ Epidemiol. 2017 Dec 21. doi: 10.1038/s41370-017-0001-1. [Epub ahead of print]
Dendup T, et al. Environmental Risk Factors for Developing Type 2 Diabetes Mellitus: A
Systematic Review. Int J Environ Res Public Health. 2018 Jan 5;15(1). pii: E78. doi: 10.3390/
ijerph15010078.
Chen M, et al. Prenatal Exposure to Diesel Exhaust PM2.5 Causes Offspring β Cell
Dysfunction in Adulthood. Am J Physiol Endocrinol Metab. 2017 Dec 26. doi: 10.1152/
ajpendo.00336.2017. [Epub ahead of print]
Tan C, et al. Long-term high air pollution exposure induced metabolic adaptations in
traffic policemen. Environ Toxicol Pharmacol. 2018 Jan 5;58:156-162. doi: 10.1016/j.etap.
2018.01.002. [Epub ahead of print]
Wang M, et al. Association between Short-Term Exposure to Air Pollution and
Dyslipidemias among Type 2 Diabetic Patients in Northwest China: A Population-Based Study.
Int J Environ Res Public Health. 2018 Mar 30;15(4). pii: E631. doi: 10.3390/ijerph15040631.
Lucht SA, et al. Air Pollution and Glucose Metabolism: An Analysis in Non-Diabetic
Participants of the Heinz Nixdorf Recall Study. Environ Health Perspect. 2018 Apr 3;126(4):
doi: 10.1289/EHP2561.
Yang BY, et al. Ambient air pollution in relation to diabetes and glucose-homoeostasis
markers in China: a cross-sectional study with findings from the 33 Communities Chinese
Health Study.Lancet Planet Health. 2018 Feb;2(2):e64-e73. doi: 10.1016/
S2542-5196(18)30001-9. Epub 2018 Feb 9.
Matthiessen C, et al. Long-term exposure to airborne particulate matter and NO2 and
prevalent and incident metabolic syndrome – Results from the Heinz Nixdorf Recall Study.
Environ Int. 2018 Apr 10;116:74-82. doi: 10.1016/j.envint.2018.02.035. [Epub ahead of print]
Kim JS, et al. Longitudinal associations of in utero and early life near-roadway air
pollution with trajectories of childhood body mass index. Environ Health. 2018 Sep 14;17(1):
doi: 10.1186/s12940-018-0409-7.
Ding S, et al. Combined effects of ambient particulate matter exposure and a high-fat diet
on oxidative stress and steatohepatitis in mice. PLoS One. 2019 Mar 28;14(3):e0214680. doi:
111
10.1371/journal.pone.0214680. eCollection 2019.

#

Miscellaneous Health Consequences

Immune suppression, inflammatory bowel disease, bacterial and viral infections, lupus,
juvenile arthritis, infant mortality, sleep apnea, obesity and suicide are elevated in
populations exposed to more air pollution.
*Air pollution can induce liver toxicity, accelerate liver inflammation and steastosis.
*Air pollution causes systemic oxidative stress, triggers the inflammatory chemical
cascade, endothelial cell death, cytotoxicity, macrophage infiltration, and increases lipid
deposition. Particulate matter penetrates intracellular structures.
Air pollution accelerates the aging process and shortens the lengths of telomeres even in
newborns.
*Air pollution increases infant mortality and SIDS
Wood smoke is uniquely toxic, the most toxic type of air pollution that most people are
ever exposed to.
*Even short term air pollution decreases fertility
*Air pollution accelerates the age related reduction in kidney function
*Osteoporosis is associated with air pollution
*Lead exposure (common in urban air pollution) is associated with significant increased
adult mortality primarily related to cardiovascular disease.

#

112

Bernatsky, S, M Fournier, CA Pineau, AE Clarke, E Vinet and A Smargiassi. 2010.
Associations between ambient fine particulate levels and disease activity in systemic lupus
erythematosus (SLE). Environmental Health Perspectives http://dx.doi.org/ 10.1289/ehp.
1002123.
Dietert RR, JC DeWitt, DR Germolec and JT Zelikoff. 2010. Breaking patterns of
environmentally influenced disease for health risk reduction: Immune perspectives.
Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.1001971.
Kaplan G, Dixon E, Panaccione R, Fong A, Chen L, et al. Effect of ambient air pollution on
the incidence of appendicitis. Published online ahead of print October 5, 2009 CMAJ 10.1503/
cmaj.082068
Bae S, Pan X-C, Kim S-Y, Park K, Kim Y-H, Kim H, et al. 2010. Exposures to Particulate
Matter and Polycyclic Aromatic Hydrocarbons and Oxidative Stress in Schoolchildren. Environ
Health Perspect 118:579-583. doi:10.1289/ehp.0901077
Geiser M, Rothen-Rutishauser B, Kapp N, Schürch S, Kreyling W, Schulz H, et al. 2005.
Ultrafine Particles Cross Cellular Membranes by Nonphagocytic Mechanisms in Lungs and in
Cultured Cells. Environ Health Perspect 113:1555-1560. doi:10.1289/ehp. 8006
Dioni L, Hoxha M, Nordio F, Bonzini M, Tarantini L, Albetti B, Savarese A, Schwartz J,
Bertazzi PA, Apostoli P, Hou L, Baccarelli A. Effects of Short-Term Exposure to Inhalable
Particulate Matter on Telomere Length, Telomerase Expression and Telomerase Methylation in
Steel Workers. Environ Health Perspect. 2010 Dec 17. [Epub ahead of print]
Zeft AS, Prahala S, Lefevre S, et al. Juvenile idiopathic arthritis and exposure to fine
particulate air pollution. Clin Exp Rheumotol 2009 Sep-Oct; 27(5):877-84
Zanobetti A, Redline S, Schwartz J, et al. Associations of PM 10 with sleep and sleepdisordered
breathing in adults from seven US urban areas. Am J Respir Crit Care Med 2010
Sept 15;182(6):819-25
Kim C, et al. Ambient Particulate Matter as a Risk Factor for Suicide. Am J Psychiatry, Sep
2010; 167: 1100 – 1107.
Kuo C, Chen V, Lee W, et al. Asthma and Suicide Mortality in Young People: A 12- Year
Follow-Up Study. Am J Psychiatry, Sep 2010; 167: 1092 – 1099.
Scheers H, Mwalili SM, Faes C, Fierens F, Nemery B, Nawrot TS 2011. Does Air Pollution
Trigger Infant Mortality in Western Europe? A Case-Crossover Study. Environ Health
Perspect :-. doi:10.1289/ehp.1002913
McCracken J, Baccarelli A, Hoxha M, Dioni L, Melly S, Coull B, Suh H, Vokonas P,
Schwartz J. Annual ambient black carbon associated with shorter telomeres in elderly men:
Veterans Affairs Normative Aging Study. Environ Health Perspect. 2010 Nov; 118(11):1564-70.
113
Xu Z, Xu X, Zhong M, Hotchkiss IP, Lewandowski RP, Wagner JG, Bramble LA, Yang Y,
Wang A, Harkema JR, Lippmann M, Rajagopalan S, Chen LC, Sun Q. Ambient Particulate Air
Pollution Induces Oxidative Stress and Alterations of Mitochondria and Gene Expression in
Brown and White Adipose Tissues. Part Fibre Toxicol. 2011 Jul 11;8(1):20. [Epub ahead of
print]
Lodovici M, Bigagli E. Oxidative stress and air pollution exposure. J Toxicol.
2011;2011:487074. Epub 2011 Aug 13.
Risom L, Møller P, Loft S. Oxidative stress-induced DNA damage by particulate air
pollution. Mutat Res. 2005 Dec 30;592(1-2):119-37. Epub 2005 Aug 8.
Williams L, Ulrich CM, Larson T, Wener MH, Wood B, Chen-Levy Z, Campbell PT, Potter
J, McTiernan A, De Roos AJ. Fine Particulate Matter (PM(2.5)) Air Pollution and Immune
Status Among Women in the Seattle Area. Arch Environ Occup Health. 2011 Jul-Sep;66(3):
155-65.
Wisnivesky JP, Teitelbaum SL, Todd AC, Boffetta P, Crane M, Crowley L, de la Hoz RE,
Dellenbaugh C, Harrison D, Herbert R, Kim H, Jeon Y, Kaplan J, Katz C, Levin S, Luft B,
Markowitz S, Moline JM, Ozbay F, Pietrzak RH, Shapiro M, Sharma V, Skloot G, Southwick S,
Stevenson LA, Udasin I, Wallenstein S, Landrigan PJ. Persistence of multiple illnesses in World
Trade Center rescue and recovery workers: a cohort study. Lancet. 2011 Sep 3;378(9794):
888-97.
Jordan HT, Brackbill RM, Cone JE, Debchoudhury I, Farfel MR, Greene CM, Hadler JL,
Kennedy J, Li J, Liff J, Stayner L, Stellman SD. Mortality among survivors of the Sept 11, 2001,
World Trade Center disaster: results from the World Trade Center Health Registry cohort.
Lancet. 2011 Sep 3;378(9794):879-87.
Ghio AJ, Carraway MS, Madden MC. Composition of air pollution particles and oxidative
stress in cells, tissues, and living systems. J Toxicol Environ Health B Crit Rev. 2012 Jan;15(1):
1-21.
Song JJ, Lee JD, Lee BD, Chae SW, Park MK. Effect of diesel exhaust particles on human
middle ear epithelial cells. Int J Pediatr Otorhinolaryngol. 2011 Dec 29. [Epub ahead of print]
Bertoldi M, Borgini A, Tittarelli A, Fattore E, Cau A, Fanelli R, Crosignani P. Health effects
for the population living near a cement plant: An epidemiological assessment. Environ Int. 2012
Jan 13;41C:1-7. [Epub ahead of print]
Gump, BB, JA MacKenzie, AK Dumas, CD Palmer, PJ Parsons, ZM Segu, YS Mechref and
KG Bendinskas. Fish consumption, low-level mercury, lipids and inflammatory markers in
children. Environmental Research http://dx.doi.org/10.1016/ j.envres.2011.10.002.
Amatullah H, North ML, Akhtar US, Rastogi N, Urch B, Silverman FS, Chow CW, Evans
GJ, Scott JA. Comparative cardiopulmonary effects of size-fractionated airborne particulate
114
matter. Inhal Toxicol. 2012 Feb 23. [Epub ahead of print]
Kloog I, Coull B, Zanobetti A, Koutrakis P, Schwartz J. Acute and Chronic Effects of
Particles on Hospital Admissions in New-England. PLoS ONE, 2012; 7 (4): e34664 DOI:
10.1371/journal.pone.0034664
Büchner N, Ale-Yagha N, Jakob S, Sydlik U, Kunze K, Unfried K, Altschmied J, Haendeler J.
Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated
phenotypic changes. Exp Gerontol. 2012 Apr 6. [Epub ahead of print]
Lim YH, Kim H, Kim JH, Bae S, Park HY, Hong YC. Air Pollution and Depressive
Symptoms in Elderly Adults. Environ Health Perspect. 2012 Apr 18. [Epub ahead of print]
Pasanen K, Eero P, Turunen A, Patama T, Jussila I, Makkonen S, Salonen, R, Verkasalo, P.
Mortality Among Population With Exposure to Industrial Air Pollution Containing Nickel and
Other Toxic Metals. Journal of Occupational & Environmental Medicine. May 2012 – Volume
54 – Issue 5 – p 583–591 doi: 10.1097/JOM. 0b013e3182492050
Xu X, Deng F, Guo X, Lv P, Zhong M, Liu C, Wang A, Tzan K, Jiang SY, Lippmann M,
Rajagopalan S, Qu Q, Chen LC, Sun Q. Association of Systemic Inflammation with Marked
Changes in Particulate Air Pollution in Beijing in 2008. Toxicol Lett. 2012 May 19. [Epub
ahead of print]
Grahame TJ, Schlesinger RB. Oxidative Stress-Induced Telomeric Erosion as a Mechanism
Underlying Airborne Particulate Matter-Related Cardiovascular Disease. Part Fibre Toxicol.
2012 Jun 19;9(1):21. [Epub ahead of print]
Berman JD, Fann N, Hollingsworth JW, Pinkerton KE, Rom WN, Szema AM, et al. 2012.
Health Benefits from Large Scale Ozone Reduction in the United States. Environ Health
Perspect :-. http://dx.doi.org/10.1289/ehp.1104851
Atkinson RW, Yu D, Armstrong BG, Pattenden S, Wilkinson P, Doherty RM, et al. 2012.
Concentration-Response Function for Ozone and Daily Mortality: Results from Five Urban and
Five Rural UK Populations. Environ Health Perspect :-. http://dx.doi.org/ 10.1289/ehp.1104108
Tong, H, AG Rappold, D Diaz-Sanchez, SE Steck, J Berntsen, WE Cascio, et al. 2012.
Omega-3 fatty acid supplementation appears to attenuate particulate air pollution induced
cardiac effects and lipid changes in healthy middle-aged adults. Environmental Health
Perspective http://dx.doi.org/10.1289/ehp.1104472.
Madrigano J, Baccarelli A, Mittleman M, et al. Air Pollution and DNA Methylation:
Interaction by Psychological Factors in the VA Normative Aging Study. Am. J. Epidemiol.
(2012) 176 (3): 224-232. doi: 10.1093/aje/kwr523
Sancini A, Tomei F, Gioffrè PA, Sinibaldi F, Corbosiero P, Rinaldi G, Marrocco M, Scimitto
L, Fiaschetti M, Tomei G, Ciarrocca M. Occupational exposure to traffic pollutants and
peripheral blood counts. Ann Ig. 2012 Jul-Aug;24(4):325-44.
115
Huang W, Wang G, Lu SE, Kipen H, Wang Y, Hu M, Lin W, Rich D, Ohman- Strickland P,
Diehl SR, Zhu P, Tong J, Gong J, Zhu T, Zhang J. Inflammatory and Oxidative Stress Responses
of Healthy Young Adults to Changes in Air Quality during the Beijing Olympics. Am J Respir
Crit Care Med. 2012 Aug 30. [Epub ahead of print]
Valdés A, Zanobetti A, Halonen J, Cifuentes L, Morata D, Schwartz J. Elemental
concentrations of ambient particles and cause specific mortality in Santiago, Chile: a time
series study. Environmental Health 2012, 11:82 doi:10.1186/1476-069X-11-82
Zhao J, Gao Z, Tian Z, Xie Y, Xin F, Jiang R, Kan H, Song W. The biological effects of
individual-level PM2.5 exposure on systemic immunity and inflammatory response in traffic
policemen. Occup Environ Med. 2013 Jan 15. [Epub ahead of print]
Fuller CH, Brugge D, Williams PL, Mittleman MA, Lane K, Durant JL, Spengler JD. Indoor
and outdoor measurements of particle number concentration in near-highway homes. J Expo Sci
Environ Epidemiol. 2013 Jan 16. doi: 10.1038/jes.2012.116. [Epub ahead of print]
Byron Lew, B. Mak Arvin. Happiness and air pollution: evidence from 14 European
countries. International Journal of Green Economics, 2013 (in press)
Migliaccio CT, Kobos E, King QO, Porter V, Jessop F, Ward T. Adverse effects of wood
smoke PM(2.5) exposure on macrophage functions. Inhal Toxicol. 2013 Feb; 25(2):67-76. doi:
10.3109/08958378.2012.756086.
YuanZ,ChenY,ZhangY,LiuH,LiuQ,ZhaoJ,HuM,HuangW,WangG,ZhuT, Zhang J, Zhu P.
Changes of plasma vWF level in response to the improvement of air quality: an observation of
114 healthy young adults. Ann Hematol. 2013 Jan 29. [Epub ahead of print]
Cupr P, Flegrová Z, Franců J, Landlová L, Klánová J. Mineralogical, chemical and
toxicological characterization of urban air particles. Environ Int. 2013 Feb 2;54C:26-34. doi:
10.1016/j.envint.2012.12.012. [Epub ahead of print]
Liu J, Zhang L, Winterroth LC, Garcia M, Weiman S, Wong JW, Sunwoo JB, Nadeau KC.
Epigenetically mediated pathogenic effects of phenanthrene on regulatory T cells. J Toxicol.
2013;2013:967029. doi: 10.1155/2013/967029. Epub 2013 Mar 7.
Reyes M, Díaz J, Tobias A, Montero JC, Linares C. Impact of Saharan dust particles on
hospital admissions in Madrid (Spain). Int J Environ Health Res. 2013 Apr 2. [Epub ahead of
print]
Mendez R, Zheng Z, Fan Z, Rajagopalan S, Sun Q, Zhang K. Exposure to fine airborne
particulate matter induces macrophage infiltration, unfolded protein response, and lipid
deposition in white adipose tissue. Am J Transl Res. 2013;5(2):224-34. Epub 2013 Mar 28.
Lue S, Wellenius G, Wilker E, Mostofsky E, Mittleman M. Residential proximity to major
roadways and renal function. J Epidemiol Community Health Published Online First: 13 May
2013 doi:10.1136/jech-2012-202307
116
Peng RD, Samoli E, Pham L, Dominici F, Touloumi G, Ramsay T, Burnett RT, Krewski D,
Le Tertre A, Cohen A, Atkinson RW, Anderson HR, Katsouyanni K, Samet JM. Acute effects of
ambient ozone on mortality in Europe and North America: results from the APHENA study. Air
Qual Atmos Health. 2013 Jun 1;6(2):445-453.
Calderón-Garcidueñas L, Mora-Tiscareño A, Franco-Lira M, Cross JV, Engle R, Aragón-
Flores M, Gómez-Garza G, Jewells V, Medina-Cortina H, Solorio E, Chao CK, Zhu H,
Mukherjee PS, Ferreira-Azevedo L, Torres-Jardón R, D’Angiulli A. Flavonol-rich dark cocoa
significantly decreases plasma endothelin-1 and improves cognition in urban children. Front
Pharmacol. 2013 Aug 22;4:104. doi: 10.3389/fphar.2013.00104.
Beamish LA, Osornio-Vargas AR, Wine E. Air pollution: An environmental factor
contributing to intestinal disease. J Crohns Colitis. 2011 Aug;5(4):279-86. doi: 10.1016/
j.crohns.2011.02.017. Epub 2011 Mar 23.
Kaplan GG, Hubbard J, Korzenik J, Sands BE, Panaccione R, Ghosh S, Wheeler AJ,
Villeneuve PJ. The inflammatory bowel diseases and ambient air pollution: a novel association.
Am J Gastroenterol. 2010 Nov;105(11):2412-9. doi: 10.1038/ajg.2010.252. Epub 2010 Jun 29.
Ananthakrishnan AN, McGinley EL, Binion DG, Saeian K. Ambient air pollution correlates
with hospitalizations for inflammatory bowel disease: an ecologic analysis. Inflamm Bowel Dis.
2011 May;17(5):1138-45. doi: 10.1002/ibd.21455. Epub 2010 Aug 30.
Kish L, Hotte N, Kaplan GG, Vincent R, Tso R, et al. (2013) Environmental Particulate
Matter Induces Murine Intestinal Inflammatory Responses and Alters the Gut Microbiome.
PLoS ONE 8(4): e62220. doi:10.1371/journal.pone.0062220
Slama R, Bottagisi S, Solansky I, Lepeule J, Giorgis-Allemand L, Sram R. Short- Term
Impact of Atmospheric Pollution on Fecundability. Epidemiology. 2013 Sep 18. [Epub ahead of
print]
Ortiz L, Nakamura B, Li X, Blumberg B, Luderer U. In Utero Exposure to Benzo[a]pyrene
Increases Adiposity and Causes Hepatic Steatosis in Female Mice, and Glutathione Deficiency
Is Protective. Toxicol Lett. 2013 Oct 6. pii: S0378-4274(13)01340-4. doi: 10.1016/j.toxlet.
2013.09.017. [Epub ahead of print]
Cimino F, Speciale A, Siracusa L, Naccari C, Saija A, Mancari F, Raciti R, Cristani M,
Trombetta D. Cytotoxic effects induced in vitro by organic extracts from urban air particulate
matter in human leukocytes. Drug Chem Toxicol. 2013 Nov 6. [Epub ahead of print]
Eum K, Weisskopf M, Nie L, Hu H, Korrick S. Cumulative Lead Exposure and Age at
Menopause in the Nurses’ Health Study Cohort. Environ Health Perspect; DOI: 10.1289/ehp.
1206399
Song Y, Ichinose T, Morita K, Nakanishi T, Kanazawa T, Yoshida Y. Asian sand dust causes
subacute peripheral immune modification with NF-κB activation. Environ Toxicol. 2013 Dec 5.
117
doi: 10.1002/tox.21931. [Epub ahead of print]
Parajulee A, Wania F. Evaluating officially reported polycyclic aromatic hydrocarbon
emissions in the Athabasca oil sands region with a multimedia fate model. Proceedings of the
National Academy of Sciences, 2014; DOI: 10.1073/pnas. 1319780111
Brochu P, Bouchard M, Haddad S. Physiological Daily Inhalation Rates for Health Risk
Assessment in Overweight/Obese Children, Adults, and Elderly. Risk Analysis, 2013; DOI:
10.1111/risa.12125
Zanobetti A1, Austin E2, Coull BA3, Schwartz J2, Koutrakis P2. Health effects of multipollutant
profiles. Environ Int. 2014 Jun 17;71C:13-19. doi: 10.1016/j.envint. 2014.05.023.
[Epub ahead of print]
Garcia CC, Freitas FP, Sanchez AB, Di Mascio P, Medeiros MH. Elevated α- methyl-γ-
hydroxy-1,N2-propano-2′-deoxyguanosine levels in urinary samples from individuals exposed to
urban air pollution. Chem Res Toxicol. 2013 Nov 18;26(11): 1602-4. doi: 10.1021/tx400273q.
Epub 2013 Nov 6.
De Roos AJ, Koehoorn M, Tamburic L, Davies HW, Brauer M. Proximity to Traffic,
Ambient Air Pollution, and Community Noise in Relation to Incident Rheumatoid Arthritis.
Environ Health Perspect. 2014 Jun 6. [Epub ahead of print]
Kim JW, Park S, Lim CW, Lee K, Kim B. The role of air pollutants in initiating liver disease.
Toxicol Res. 2014 Jun;30(2):65-70. doi: 10.5487/TR.2014.30.2.065.
Mahalingaiah S, Hart J, Laden F, Terry K, Boynton-Jarrett R, Aschengrau A, Missmer S.
Air Pollution and Risk of Uterine Leiomyomata. Epidemiology: September 2014 – Volume 25 –
Issue 5 – p 682-688 doi: 10.1097/EDE.0000000000000126.
Awji EG, Chand H, Bruse S, Smith KR, Colby JK, Mebratu Y, Levy BD, Tesfaigzi Y. Wood
Smoke Enhances Cigarette Smoke-Induced Inflammation by Inducing the Aryl Hydrocarbon
Receptor Repressor in Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2014 Aug 19. [Epub
ahead of print]
Frutos V, González-Comadrán M, Solà I, Jacquemin B, Carreras R, Checa Vizcaíno MA.
Impact of air pollution on fertility: a systematic review. Gynecol Endocrinol. 2014 Sep 12:1-7.
[Epub ahead of print]
Edwards PM, et al. High winter ozone pollution from carbonyl photolysis in an oil and gas
basin. Nature. 2014 Oct 1. doi: 10.1038/nature13767. [Epub ahead of print]
Rylance J, et al. Household Air Pollution Causes Dose-dependent Inflammation and Altered
Phagocytosis in Human Macrophages. Am J Respir Cell Mol Biol. 2014 Sep 25. [Epub ahead of
print]
Saffari A, Daher N, Shafer MM, Schauer JJ, Sioutas C. Global perspective on the oxidative
potential of airborne particulate matter: a synthesis of research findings. Environ Sci Technol.
118
2014 Jul 1;48(13):7576-83. doi: 10.1021/es500937x. Epub 2014 Jun 10.
Rengaraj D, Kwon WS, Pang MG. Effects of motor vehicle exhaust on male reproductive
function and associated proteins. J Proteome Res. 2014 Oct 20. [Epub ahead of print]
Macey GP, Breech R, Chernaik M, Cox C, Larson D, Thomas D, Carpenter DO. Air
concentrations of volatile compounds near oil and gas production: a community- based
exploratory study. Environ Health. 2014 Oct 30;13:82. doi: 10.1186/1476-069X-13-82.
McConnell R, Shen E, Gilliland FD, Jerrett M, Wolch J, Chang CC, Lurmann F, Berhane
K. A Longitudinal Cohort Study of Body Mass Index and Childhood Exposure to Secondhand
Tobacco Smoke and Air Pollution: The Southern California Children’s Health Study. Environ
Health Perspect. 2014 Nov 12. [Epub ahead of print]
Kheirandish-Gozal L, Ghalebandi M, Salehi M, Salarifar MH, Gozal D. Neighbourhood air
quality and snoring in school-aged children. Eur Respir J. 2014 Mar; 43(3):824-32. doi:
10.1183/09031936.00113113. Epub 2013 Aug 29.
Bakian AV, Huber RS, Coon H, Gray D, Wilson P, McMahon WM, Renshaw PF. Acute Air
Pollution Exposure and Risk of Suicide Completion. Am J Epidemiol. 2015 Feb 10. pii: kwu341.
[Epub ahead of print]
Chen Z, Salam MT, Karim R, Toledo-Corral CM, Watanabe RM, Xiang AH, Buchanan TA,
Habre R. Living near a freeway is associated with lower bone mineral density among Mexican
Americans. Osteoporos Int. 2015 Feb 13. [Epub ahead of print]
Shen G, et al. Emission and Size Distribution of Particle-bound Polycyclic Aromatic
Hydrocarbons from Residential Wood Combustion. Biomass Bioenergy. 2014 Aug;55:141-147.
McEachran AD, Blackwell BR, Hanson JD, Wooten KJ, Mayer GD, Cox SB, Smith PN.
Antibiotics, Bacteria, and Antibiotic Resistance Genes: Aerial Transport from Cattle Feed Yards
via Particulate Matter. Environ Health Perspect. 2015 Jan 22. [Epub ahead of print]
Díaz-Roblesa, LA, et al. Health risks caused by short term exposure to ultrafine particles
generated by residential wood combustion: A case study of Temuco, Chile. Environment
International. Volume 66, May 2014, Pages 174–181
Kioumourtzoglou MA, Austin E, Koutrakis P, Dominici F, Schwartz J, Zanobetti A. PM2.5
and Survival Among Older Adults: Effect Modification by Particulate Composition.
Epidemiology. 2015 Feb 25. [Epub ahead of print]
Calderón-Garcidueñas L, et al. Mexico City normal weight children exposed to high
concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D
deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for
obesity and Alzheimer disease. Environ Res. 2015 May 30;140:579-592. doi: 10.1016/j.envres.
2015.05.012. [Epub ahead of print]
Héroux ME, et al. Quantifying the health impacts of ambient air pollutants:
119
recommendations of a WHO/Europe project. Int J Public Health. 2015 May 30. [Epub ahead of
print]
Cui Y, et al. Ambient Fine Particulate Matter Suppresses In Vivo Proliferation of Bone
Marrow Stem Cells through Reactive Oxygen Species Formation. PLoS One. 2015 Jun
9;10(6):e0127309. doi: 10.1371/journal.pone.0127309. eCollection 2015.
Lanki T, et al. Air Pollution from Road Traffic and Systemic Inflammation in Adults: A
Cross-Sectional Analysis in the European ESCAPE Project. Environ Health Perspect; DOI:
10.1289/ehp.1408224
Woodruff T, et al. Air Pollution and Postneonatal Infant Mortality in the United States,
1999–2002 Environ Health Perspect. 2008 Jan; 116(1): 110–115. Published online 2007 Oct
doi: 10.1289/ehp.10370
Shim SR, Kim JH, Song YS, Lee WJ. Association between Air Pollution and Benign
Prostatic Hyperplasia: An Ecological Study. Arch Environ Occup Health. 2015 Sep 17:0.
[Epub ahead of print]
Reed J, Dela Cruz AL, Lomnicki SM, Backes WL. Environmentally persistent free radicalcontaining
particulate matter competitively inhibits metabolism by cytochrome P450 1A2.
Toxicol Appl Pharmacol. 2015 Sep 27. pii: S0041-008X(15)30095-8. doi: 10.1016/j.taap.
2015.09.021. [Epub ahead of print]
McGrath JM, et al. An analysis of ozone damage to historical maize and soybean yields in
the United States. Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):14390-5. doi: 10.1073/pnas.
Epub 2015 Nov 2.
Pieters N, et al. Biomolecular Markers Within the Core Axis of Aging and Particulate Air
Pollution Exposure in the Elderly: A Cross-Sectional Study. Environ Health Perspect. 2015
Dec 15. [Epub ahead of print]
Miller D, et al. Ozone Exposure Increases Circulating Stress Hormones and Lipid
Metabolites in Humans. Am J Respir Crit Care Med. 2016 Jan 8. [Epub ahead of print]
Singleton B, et al. Environmental stress in the Gulf of Mexico and its potential impact on
public health. Environ Res. 2015 Dec 30;146:108-115. doi: 10.1016/j.envres.2015.12.019.
[Epub ahead of print]
Feng C, Li J, Sun W, Zhang Y, Wang Q. Impact of ambient fine particulate matter (PM2.5)
exposure on the risk of influenza-like-illness: a time-series analysis in Beijing, China. Environ
Health. 2016 Feb 11;15(1):17. doi: 10.1186/s12940-016-0115-2.
Burchiel SW, et al. Changes in HPBMC markers of immune function following controlled
short-term inhalation exposures of humans to hardwood smoke. Inhal Toxicol. 2016 Feb;28(2):
61-70.
Li W, et al. Short-Term Exposure to Air Pollution and Biomarkers of Oxidative Stress: The
120
Framingham Heart Study. J Am Heart Assoc. 2016 Apr 28;5(5). pii: e002742. doi: 10.1161/
JAHA.115.002742.
Reid CE, et al. Critical Review of Health Impacts of Wildfire Smoke Exposure. Environ
Health Perspect. 2016 Apr 15. [Epub ahead of print]
Nucci P, et al. Pediatric Conjunctivitis and Air Pollution Exposure: A Prospective
Observational Study. Semin Ophthalmol. 2016 Apr 15:1-5. [Epub ahead of print]
Cox B, Gasparrini A, Catry B, Fierens F, Vangronsveld J, Nawrot TS. Ambient Air
Pollution-Related Mortality in Dairy Cattle: Does It Corroborate Human Findings?
Epidemiology. 2016 Jul 27. [Epub ahead of print]
Kollanus V, Prank M, Gens A, Soares J, Vira J, Kukkonen J, Sofiev M, Salonen RO, Lanki
T. Mortality due to Vegetation-Fire Originated PM2.5 Exposure in Europe – Assessment for the
Years 2005 and 2008. Environ Health Perspect. 2016 Jul 29. [Epub ahead of print]
Leggy J, et al. Oil sands operations as a large source of secondary organic aerosolsNature
(2016) doi:10.1038/nature17646
Dėdelė A, et al. Seasonal variation of indoor and outdoor air quality of nitrogen dioxide
in homes with gas and electric stoves. Environ Sci Pollut Res Int. 2016 Jun 1. [Epub ahead of
print]
Jung CR, et al. Ambient Air Pollutant Exposures and Hospitalization for Kawasaki
Disease in Taiwan: A Case-Crossover Study (2000-2010) Environ Health Perspect; DOI:
10.1289/EHP137
White A, et al. Antimüllerian hormone (AMH) in relation to tobacco and marijuana use
and sources of indoor heating/cooking. Fertil Steril. 2016 May 27. pii:
S0015-0282(16)61282-7. doi: 10.1016/j.fertnstert.2016.05.015. [Epub ahead of print]
Bourciera L, et al. Experimental evidence of biomass burning as a source of atmospheric
137Cs, puy de Dôme (1465 m a.s.l.), France. Atmospheric Environment. Volume 44, Issue 19,
June 2010, Pages 2280–2286
Ostro B, Malig B, Hasheminassab S, Berger K, Chang E, Sioutas C. Associations of
Source-Specific Fine Particulate Matter With Emergency Department Visits in California. Am J
Epidemiol. 2016 Sep 6. pii: kwv343. [Epub ahead of print]
Zeft AS, et al. Systemic onset juvenile idiopathic arthritis and exposure to fine particulate
air pollution. Clin Exp Rheumatol. 2016 Sep 1. [Epub ahead of print]
Uni D, et al. Airborne dust absorption by semi-arid forests reduces PM pollution in
nearby urban environments. Sci Total Environ. 2017 Apr 29;598:984-992. doi: 10.1016/
j.scitotenv.2017.04.162. [Epub ahead of print]
Huang JV, Leung GM, Schooling CM. The Association of Air Pollution With Pubertal
Development: Evidence From Hong Kong’s “Children of 1997” Birth Cohort. Am J Epidemiol.
121
2017 Apr 21:1-10. doi: 10.1093/aje/kww200. [Epub ahead of print]
Kim YM, Kim J, Han Y1 Jeon BH, Cheong HK, Ahn K. Short-term effects of weather and
air pollution on atopic dermatitis symptoms in children: A panel study in Korea. PLoS One.
2017 Apr 6;12(4):e0175229. doi: 10.1371/journal.pone.0175229. eCollection 2017.
van der Sloot KWJ, Amini M, Peters V, Dijkstra G, Alizadeh BZ. Inflammatory Bowel
Diseases: Review of Known Environmental Protective and Risk Factors Involved. Inflamm
Bowel Dis. 2017 Aug 2. doi: 10.1097/MIB.0000000000001217. [Epub ahead of print]
van der Sloot KWJ, Amini M, Peters V, Dijkstra G, Alizadeh BZ. Inflammatory Bowel
Diseases: Review of Known Environmental Protective and Risk Factors Involved. Inflamm
Bowel Dis. 2017 Aug 2. doi: 10.1097/MIB.0000000000001217. [Epub ahead of print]
Psoter KJ, De Roos AJ, Wakefield J, Mayer JD, Rosenfeld M. Air pollution exposure is
associated with MRSA acquisition in young U.S. children with cystic fibrosis. BMC Pulm Med.
2017 Jul 27;17(1):106. doi: 10.1186/s12890-017-0449-8.
Li W, et al. Short-Term Exposure to Ambient Air Pollution and Biomarkers of Systemic
Inflammation: The Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2017 Jul 27. pii:
ATVBAHA.117.309799. doi: 10.1161/ATVBAHA.117.309799. [Epub ahead of print]
Vreeland H, et al. Oxidative potential of PM 2.5 during Atlanta rush hour: Measurements
of in-vehicle dithiothreitol (DTT) activity. Atmospheric Environment, 2017; 165: 169 DOI:
10.1016/j.atmosenv.2017.06.044
Merklinger-Gruchala A, et al. Effect of Air Pollution on Menstrual Cycle Length-A
Prognostic Factor of Women’s Reproductive Health. Int J Environ Res Public Health. 2017 Jul
20;14(7). pii: E816. doi: 10.3390/ijerph14070816.
Hsieh S, et al. Traffic-related air pollution associations with cytokeratin-18, a marker of
hepatocellular apoptosis, in an overweight and obese paediatric population. Pediatr Obes.
2017 Jul 20. doi: 10.1111/ijpo.12228. [Epub ahead of print]
Wu XM, et al. Association between gaseous air pollutants and inflammatory, hemostatic
and lipid markers in a cohort of midlife women. Environ Int. 2017 Jul 18;107:131-139. doi:
10.1016/j.envint.2017.07.004. [Epub ahead of print]
Girguis MS, et al. Chronic PM2.5 exposure and risk of infant bronchiolitis and otitis
media clinical encounters. Int J Hyg Environ Health. 2017 Jul 1. pii: S1438-4639(17)30219-5.
doi: 10.1016/j.ijheh.2017.06.007. [Epub ahead of print]
Nuvolone D, Petri D, Voller F. The effects of ozone on human health. Environ Sci Pollut
Res Int. 2017 May 25. doi: 10.1007/s11356-017-9239-3. [Epub ahead of print]
Li H, et al. Particulate Matter Exposure and Stress Hormone Levels: A Randomized,
Double-Blind, Crossover Trial of Air Purification https://doi.org/10.1161/
CIRCULATIONAHA.116.026796 Circulation. 2017;136:618-627
122
Wang C, et al. Acute Inflammation Following Personal Exposure to Fine-particulate Air
Pollution.Am J Epidemiol. 2017 Aug 17. doi: 10.1093/aje/kwx277. [Epub ahead of print]
Bowe B, et al. Particulate Matter Air Pollution and the Risk of Incident CKD and
Progression to ESRD. J Am Soc Nephrol. 2017 Sep 21. pii: ASN.2017030253. doi: 10.1681/
ASN.2017030253. [Epub ahead of print]
Blount, R, et al. Traffic-Related Air Pollution and All-Cause Mortality during
Tuberculosis Treatment in California. Environ Health Perspect; DOI:10.1289/EHP1699
Son JY, et al. Pregnancy and Lifetime Exposure to Fine Particulate Matter and Infant
Mortality in Massachusetts, 2001-2007. Am J Epidemiol. 2017 Nov 7:1-9. doi: 10.1093/aje/
kwx015. [Epub ahead of print]
Prada, D, Zhong, J, Colicino, E et al. Association of air particulate pollution with bone
loss over time and bone fracture risk: analysis of data from two independent studies. Lancet
Planet Health. 2017; 1: e337–e347
Zhao R, et al. Nasal epithelial barrier disruption by particulate matter ≤2.5 μm via tight
junction protein degradation. J Appl Toxicol. 2017 Dec 13. doi: 10.1002/jat.3573. [Epub ahead
of print]
França C, et al. Risk Factors Associated with Juvenile Idiopathic Arthritis: Exposure to
Cigarette Smoke and Air Pollution from Pregnancy to Disease Diagnosis. J Rheumatol. 2017
Nov 15. pii: jrheum.161500. doi: 10.3899/jrheum.161500. [Epub ahead of print]
Alves AGF, et al. Influence of air pollution on airway inflammation and disease activity in
childhood-systemic lupus erythematosus. Clin Rheumatol. 2017 Nov 2. doi: 10.1007/
s10067-017-3893-1. [Epub ahead of print]
Borghini A, et al. Environmental Pollution by Benzene and PM10 and Clinical
Manifestations of Systemic Sclerosis: A Correlation Study. Int J Environ Res Public Health.
2017 Oct 26;14(11). pii: E1297. doi: 10.3390/ijerph14111297.
de Zwart F, et al. Air Pollution and Performance-Based Physical Functioning in Dutch
Older Adults. Environ Health Perspect. 2018 Jan 19;126(1):017009. doi: 10.1289/EHP2239.
Markandya A, et al. Health co-benefits from air pollution and mitigation costs of the
Paris Agreement: a modeling study. Lancet Planet Health. 2018 Mar;2(3):e126-e133. doi:
10.1016/S2542-5196(18)30029-9. Epub 2018 Mar 2.
Chen R, et al. Associations between ambient nitrogen dioxide and daily cause-specific
mortality: Evidence from 272 Chinese cities. Epidemiology. 2018 Apr 4. doi: 10.1097/EDE.
[Epub ahead of print]
Bean JK, et al. Formation of Particulate Matter from the Oxidation of Evaporated
Hydraulic Fracturing Wastewater. Environ Sci Technol. 2018 Mar 29. doi: 10.1021/acs.est.
7b06009. [Epub ahead of print]
123
Li D, et al. Association between short-term exposure to ambient air pollution and daily
mortality: a time-series study in Eastern China. Environ Sci Pollut Res Int. 2018 Mar 29. doi:
10.1007/s11356-018-1759-y. [Epub ahead of print]
Lanphear B, et al. Low-level lead exposure and mortality in US adults: a populationbased
cohort study. The Lancet Public Health, 2018 DOI: 10.1016/S2468-2667(18)30025-2
Huang J, Pan X, Guo X, Li G. Impacts of air pollution wave on years of life lost: A crucial
way to communicate the health risks of air pollution to the public. Environ Int. 2018 Jan
29;113:42-49. doi: 10.1016/j.envint.2018.01.022. [Epub ahead of print] PMID: 29421406
[PubMed – as supplied by publisher]
Cromar KR, Gladson LA, Ghazipura M, Ewart G. ATS and Marron Institute Report:
Estimated Excess Morbidity and Mortality Associated with Air Pollution above ATSRecommended
Standards, 2013-2015. Ann Am Thorac Soc. 2018 Feb 9. doi: 10.1513/
AnnalsATS.201710-785EH. [Epub ahead of print] No abstract available. PMID: 29425050
[PubMed – as supplied by publisher]
Mutlu EA, et al. Inhalational exposure to particulate matter air pollution alters the
composition of the gut microbiome. Environ Pollut. 2018 May 18;240:817-830. doi: 10.1016/
j.envpol.2018.04.130. [Epub ahead of print]
Malmqvist E, et al. Estimated health benefits of exhaust free transport in the city of
Malmö, Southern Sweden. Environment International, 2018; 118: 78 DOI: 10.1016/j.envint.
2018.05.035
Yitshak-Sade M, et al. The association between short and long-term exposure to PM2.5
and temperature and hospital admissions in New England and the synergistic effect of the shortterm
exposures. Sci Total Environ. 2018 Oct 15;639:868-875. doi: 10.1016/j.scitotenv.
2018.05.181. Epub 2018 May 26.
Park M, et al. Air pollution influences the incidence of otitis media in children: A national
population-based study. PLoS One. 2018 Jun 28;13(6):e0199296. doi: 10.1371/journal.pone.
eCollection 2018.
Pasqua LA, et al. Exercising in Air Pollution: The Cleanest versus Dirtiest Cities
Challenge.Int J Environ Res Public Health. 2018 Jul 17;15(7). pii: E1502. doi: 10.3390/
ijerph15071502.
Guan T, et al. The effects of face masks on airway inflammation and endothelial
dysfunction in healthy young adults: a double-blind, randomized, controlled crossover study.
Part Fibre Toxicol. 2018 Jul 4;15(1):30. doi: 10.1186/s12989-018-0266-0.
Park SY, et al. Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter
(PM10) on Human Dermal Fibroblasts. Int J Mol Sci. 2018 Sep 12;19(9). pii: E2727. doi:
10.3390/ijms19092727.
124
Schwartz J, et al. A National Multicity Analysis of the Causal Effect of Local Pollution,
[Formula: see text], and [Formula: see text] on Mortality. Environ Health Perspect. 2018 Aug;
126(8):87004. doi: 10.1289/EHP2732.
Jans J, et al. Economic status, air quality, and child health: Evidence from inversion
episodes. J Health Econ. 2018 Aug 16;61:220-232. doi: 10.1016/j.jhealeco.2018.08.002. [Epub
ahead of print]
Kim JH, et al. Premature Deaths Attributable to Long-term Exposure to Ambient Fine
Particulate Matter in the Republic of Korea. J Korean Med Sci. 2018 Aug 23;33(37):e251. doi:
10.3346/jkms.2018.33.e251. eCollection 2018 Sep 10.
Heft-Neal S. et al. Robust relationship between air quality and infant mortality in
AfricaNature volume 559, pages254–258 (2018)
Hill EL, et al. Shale gas development and infant health: Evidence from Pennsylvania.J
Health Econ. 2018 Aug 13;61:134-150. doi: 10.1016/j.jhealeco.2018.07.004. [Epub ahead of
print]
Aroui H, et al. The effect of environmental factors on the incidence of perforated
appendicitis. Ann Ital Chir. 2018 Jul 23;7. pii: S0003469X18028014. [Epub ahead of print]
Chen CC, et al. Effects of ambient air pollution exposure on frequency of hospital
admissions for appendicitis in Taipei, Taiwan.J Toxicol Environ Health A. 2018 Jul 26:1-7. doi:
10.1080/15287394.2018.1498276. [Epub ahead of print]
Wooding DJ, et al. Particle Depletion Does Not Remediate Acute Effects of Traffic-
Related Air Pollution and Allergen: A Randomized, Double-Blinded Crossover Study. Am J
Respir Crit Care Med. 2019 Apr 12. doi: 10.1164/rccm.201809-1657OC. [Epub ahead of print]
Billings ME, et al. The Association of Ambient Air Pollution with Sleep Apnea: The Multi-
Ethnic Study of Atherosclerosis. Ann Am Thorac Soc. 2018 Dec 20. doi: 10.1513/AnnalsATS.
201804-248OC. [Epub ahead of print]
Friedrich MJ. Global Impact of Air Pollution on Children’s Health. JAMA. 2018 Dec
18;320(23):2412. doi: 10.1001/jama.2018.19559.
Baek K, et al. Impact of Heart Disease Risk Factors, Respiratory Illness, Mastery, and
Quality of Life on the Health Status of Individuals Living Near a Major Railyard in Southern
California. Int J Environ Res Public Health. 2018 Dec 6;15(12). pii: E2765. doi: 10.3390/
ijerph15122765.
Yang Y, et al. Short-term and long-term exposures to fine particulate matter constituents
and health: A systematic review and meta-analysis. Environ Pollut. 2018 Dec 21;247:874-882.
doi: 10.1016/j.envpol.2018.12.060. [Epub ahead of print]
Lin CY, et al. The effects of exposure to air pollution on the development of uterine
fibroids. Int J Hyg Environ Health. 2019 Feb 25. pii: S1438-4639(18)30882-4. doi: 10.1016/
125
j.ijheh.2019.02.004. [Epub ahead of print]